Clinical effectiveness of subsensory sacral neuromodulation in adults with faecal incontinence: the SUBSoNIC crossover RCT and mechanistic study

Trial design Randomised, multicentre, double-blind crossover trial (with 2 × 16-week periods) of active neurostimulation versus sham stimulation with subsequent open-label follow-up to 58 weeks. Embedded mechanistic sub-study using magnetoencephalography to study bidirectional functional connectivit...

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Main Authors:	Paul F Vollebregt, Yan Li Goh, Claire L Chan, Thomas Dudding, Paul Furlong, Shaheen Hamdy, Joanne Haviland, Richard Hooper, James Jones, Eleanor McAlees, Christine Norton, P Ronan O’Connell, S Mark Scott, Natasha Stevens, Kerry Tubby, Sian Worthen, Yuk Lam Wong, Charles H Knowles
Format:	Article
Language:	English
Published:	NIHR Journals Library 2024-11-01
Series:	Efficacy and Mechanism Evaluation
Subjects:	humans adult faecal incontinence magnetoencephalography follow-up studies cross-over studies arm healthy volunteers sample size covid-19 brain electric stimulation therapy randomised controlled trial mechanistic study
Online Access:	https://doi.org/10.3310/JYWT9670
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Clinical effectiveness of subsensory sacral neuromodulation in adults with faecal incontinence: the SUBSoNIC crossover RCT and mechanistic study

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