Nonhistone lactylation: A hub for tumour metabolic reprogramming and epigenetic regulation

Nonhistone lactylation: A hub for tumour metabolic reprogramming and epigenetic regulation

Abstract Recent research has shifted the perception of lactate from being merely a byproduct of metabolism to being a crucial signalling molecule and epigenetic regulator in tumours. This paper provides a comprehensive review of the mechanisms by which the lactylation of nonhistones contributes to t...

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Main Authors: Dawei Zhang, Changming Liang, Chengwei Wu, Michael Hawanga, Senlin Wan, Lishuai Xu, Xu Zhang, Yongchun Liu, Fangshuai Hu, Mengyun Wang, Xiaoming Wang, Li Xu, Xiaoxu Huang
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Translational Medicine
Subjects:
Nonhistone lactylation
Warburg effect
Metabolic reprogramming
Tumorigenesis
Targeted therapy
Online Access:https://doi.org/10.1186/s12967-025-06813-8
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https://doi.org/10.1186/s12967-025-06813-8

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