Comparison of Hepcidin Level, Blood Parameters and Inflammatory Markers in High Flux Hemodialysis and Hemodiafiltration Patients
Background and Objective: Healthy kidneys filter wastes of various molecular masses (up to 40-60 kDa). Traditional hemodialysis only removes low-molecular-weight molecules (500 Da), not middle-weight substances (>500 Da). Therefore, most of these compounds remain as expected uremic toxins. Theref...
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| Format: | Article |
| Language: | English |
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Babol University of Medical Sciences
2024-03-01
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| Series: | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul |
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| Online Access: | http://jbums.org/article-1-11360-en.pdf |
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| author | MY Naji Al-Atbee H Sami Tuama R Abdulwahid Gatee MM Salih Hasan S Ali Salman Gh Hasan Mahmood |
| author_facet | MY Naji Al-Atbee H Sami Tuama R Abdulwahid Gatee MM Salih Hasan S Ali Salman Gh Hasan Mahmood |
| author_sort | MY Naji Al-Atbee |
| collection | DOAJ |
| description | Background and Objective: Healthy kidneys filter wastes of various molecular masses (up to 40-60 kDa). Traditional hemodialysis only removes low-molecular-weight molecules (500 Da), not middle-weight substances (>500 Da). Therefore, most of these compounds remain as expected uremic toxins. Therefore, this study aims to determine the association of Hepcidin and anemia with inflammatory markers in dialysis cases on high flux hemodialysis (HD) compared with hemodiafiltration (HDF).
Methods: This cross-sectional study was conducted on 203 patients in the age range of 20-70 years old with end-stage kidney disease who were undergoing hemodialysis using high flux and hemodiafiltration methods. Venous blood samples were taken without anticoagulation and ferritin, CRP and hepcidin levels were analyzed and compared.
Findings: This study involved 203 cases with end-stage renal disease, with 103 in the HD group and 100 in the HDF group. The mean age of the cases was 49.5±15.5 years. Among the patients in the HD group, 79.9% had hypertension, while only 23% of the patients in the HDF group had hypertension. Additionally, 35.9% of the cases in the HD group had diabetes mellitus (DM), while 75% of the cases in the HDF group had DM. There were significant differences between the mean number of white blood cells (8.27±7.95 vs. 6.20±4.14), CRP (13.88±17.45 vs. 6.48±10.40) and hepcidin (2981.47±2325.38 vs. 1010.45±1136.18) between the groups (p<0.05).
Conclusion: The results of this study showed that individuals receiving HDF have low-grade inflammation, less anemia, and a superior response to erythropoietin. Therefore, for patients with elevated inflammatory markers, the HDF dialysis modality is suggested. |
| format | Article |
| id | doaj-art-4a75edfe9cd9426e81e65ae8f6619f6c |
| institution | Kabale University |
| issn | 1561-4107 2251-7170 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Babol University of Medical Sciences |
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| series | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul |
| spelling | doaj-art-4a75edfe9cd9426e81e65ae8f6619f6c2024-12-10T09:44:47ZengBabol University of Medical SciencesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul1561-41072251-71702024-03-012600Comparison of Hepcidin Level, Blood Parameters and Inflammatory Markers in High Flux Hemodialysis and Hemodiafiltration PatientsMY Naji Al-Atbee0H Sami Tuama1R Abdulwahid Gatee2MM Salih Hasan3S Ali Salman4Gh Hasan Mahmood5 1.College of Medicine, University of Basrah, Basra, Iraq. 2.Family Physician, Basrah Primary Health Care, Basra, Iraq. 3.Nephrology and Dialysis Center, Basrah Teaching Hospital, Basra, Iraq. 3.Nephrology and Dialysis Center, Basrah Teaching Hospital, Basra, Iraq. 4.College of Science, Tikrit University, Tikrit, Iraq. 5.College of Pharmacy, Al-Farahidi University, Baghdad, Iraq. Background and Objective: Healthy kidneys filter wastes of various molecular masses (up to 40-60 kDa). Traditional hemodialysis only removes low-molecular-weight molecules (500 Da), not middle-weight substances (>500 Da). Therefore, most of these compounds remain as expected uremic toxins. Therefore, this study aims to determine the association of Hepcidin and anemia with inflammatory markers in dialysis cases on high flux hemodialysis (HD) compared with hemodiafiltration (HDF). Methods: This cross-sectional study was conducted on 203 patients in the age range of 20-70 years old with end-stage kidney disease who were undergoing hemodialysis using high flux and hemodiafiltration methods. Venous blood samples were taken without anticoagulation and ferritin, CRP and hepcidin levels were analyzed and compared. Findings: This study involved 203 cases with end-stage renal disease, with 103 in the HD group and 100 in the HDF group. The mean age of the cases was 49.5±15.5 years. Among the patients in the HD group, 79.9% had hypertension, while only 23% of the patients in the HDF group had hypertension. Additionally, 35.9% of the cases in the HD group had diabetes mellitus (DM), while 75% of the cases in the HDF group had DM. There were significant differences between the mean number of white blood cells (8.27±7.95 vs. 6.20±4.14), CRP (13.88±17.45 vs. 6.48±10.40) and hepcidin (2981.47±2325.38 vs. 1010.45±1136.18) between the groups (p<0.05). Conclusion: The results of this study showed that individuals receiving HDF have low-grade inflammation, less anemia, and a superior response to erythropoietin. Therefore, for patients with elevated inflammatory markers, the HDF dialysis modality is suggested.http://jbums.org/article-1-11360-en.pdfhepcidinanemiainflammatory markers in dialysishigh flux hemodialysis (hd)hemodiafiltration (hdf). |
| spellingShingle | MY Naji Al-Atbee H Sami Tuama R Abdulwahid Gatee MM Salih Hasan S Ali Salman Gh Hasan Mahmood Comparison of Hepcidin Level, Blood Parameters and Inflammatory Markers in High Flux Hemodialysis and Hemodiafiltration Patients Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul hepcidin anemia inflammatory markers in dialysis high flux hemodialysis (hd) hemodiafiltration (hdf). |
| title | Comparison of Hepcidin Level, Blood Parameters and Inflammatory Markers in High Flux Hemodialysis and Hemodiafiltration Patients |
| title_full | Comparison of Hepcidin Level, Blood Parameters and Inflammatory Markers in High Flux Hemodialysis and Hemodiafiltration Patients |
| title_fullStr | Comparison of Hepcidin Level, Blood Parameters and Inflammatory Markers in High Flux Hemodialysis and Hemodiafiltration Patients |
| title_full_unstemmed | Comparison of Hepcidin Level, Blood Parameters and Inflammatory Markers in High Flux Hemodialysis and Hemodiafiltration Patients |
| title_short | Comparison of Hepcidin Level, Blood Parameters and Inflammatory Markers in High Flux Hemodialysis and Hemodiafiltration Patients |
| title_sort | comparison of hepcidin level blood parameters and inflammatory markers in high flux hemodialysis and hemodiafiltration patients |
| topic | hepcidin anemia inflammatory markers in dialysis high flux hemodialysis (hd) hemodiafiltration (hdf). |
| url | http://jbums.org/article-1-11360-en.pdf |
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