Helicobacter pylori outer membrane vesicles directly promote Aβ aggregation and enhance Aβ toxicity in APP/PS1 mice

Helicobacter pylori outer membrane vesicles directly promote Aβ aggregation and enhance Aβ toxicity in APP/PS1 mice

Abstract Helicobacter pylori (H. pylori) infection has been found associated with Alzheimer’s disease (AD) with unclear mechanisms. Outer Membrane Vesicles (OMVs) are spherical particles secreted by Gram-negative bacteria. Here we explore the effect of H. pylori OMVs on Aβ aggregation and toxicity....

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Main Authors: Dongli Meng, Yiwen Lai, Lun Zhang, Wenting Hu, Hui Wei, Cuiping Guo, Xiaopeng Jing, Huan Zhou, Rui Xiao, Liping Zhu, Shengquan Luo, Zhendong Xu, Yu Chen, Xiaochuan Wang, Rong Liu, Ji Zeng
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-07125-1
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