Using platelet concentrates to treat maxillofacial tissue lesions
ObjectivesPlatelet concentrates (PCs), which are blood products that are abundant in platelets and growth factors, have become pivotal in treating maxillofacial tissue lesions due to their capacity for promoting bone and soft tissue recovery. This review will provide some recent progress of the use...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1523225/full |
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| author | Ruijia Liu Siqi Chen Peng Wang Peng Wang Ruiye Bi Ruiye Bi |
| author_facet | Ruijia Liu Siqi Chen Peng Wang Peng Wang Ruiye Bi Ruiye Bi |
| author_sort | Ruijia Liu |
| collection | DOAJ |
| description | ObjectivesPlatelet concentrates (PCs), which are blood products that are abundant in platelets and growth factors, have become pivotal in treating maxillofacial tissue lesions due to their capacity for promoting bone and soft tissue recovery. This review will provide some recent progress of the use of platelet concentrates to treat lesions on maxillofacial tissues.SubjectsWe reviewed the mechanisms by which PCs promote wound healing and tissue recovery and summarized the application of PCs in the treatment of lesions on maxillofacial tissues, including medication-related osteonecrosis of the jaw, post-extraction wound healing, implant surgery, temporomandibular joint diseases, and periodontal tissue restoration.ResultsPC promotes the attachment and proliferation of osteoblasts, as well as the synthesis and deposition of collagen fibers by stimulating the AFK pathway and releasing growth factors and cytokines, such as secreting GFs, VEGF, TGF-β, etc. They also induce angiogenesis, inhibit bone resorption, promote the healing of soft tissues, relieve symptoms, reduce postoperative complications and maintain implant stability.ConclusionPCs may be used as an adjuvant therapy in the treatment of lesions on maxillofacial tissues. However, more studies should refine the preparation and treatment methods for platelet concentrates and establish a foundation for their extensive application. |
| format | Article |
| id | doaj-art-4a5aa3e7d05f4014960094d62c6f35b2 |
| institution | Kabale University |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-4a5aa3e7d05f4014960094d62c6f35b22025-01-07T06:40:37ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-01-011210.3389/fbioe.2024.15232251523225Using platelet concentrates to treat maxillofacial tissue lesionsRuijia Liu0Siqi Chen1Peng Wang2Peng Wang3Ruiye Bi4Ruiye Bi5State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, Sichuan University, Chengdu, ChinaNational Clinical Research Center for Oral Diseases, Department of Orthognathic and TMJ Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, Sichuan University, Chengdu, ChinaNational Clinical Research Center for Oral Diseases, Department of Orthognathic and TMJ Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaObjectivesPlatelet concentrates (PCs), which are blood products that are abundant in platelets and growth factors, have become pivotal in treating maxillofacial tissue lesions due to their capacity for promoting bone and soft tissue recovery. This review will provide some recent progress of the use of platelet concentrates to treat lesions on maxillofacial tissues.SubjectsWe reviewed the mechanisms by which PCs promote wound healing and tissue recovery and summarized the application of PCs in the treatment of lesions on maxillofacial tissues, including medication-related osteonecrosis of the jaw, post-extraction wound healing, implant surgery, temporomandibular joint diseases, and periodontal tissue restoration.ResultsPC promotes the attachment and proliferation of osteoblasts, as well as the synthesis and deposition of collagen fibers by stimulating the AFK pathway and releasing growth factors and cytokines, such as secreting GFs, VEGF, TGF-β, etc. They also induce angiogenesis, inhibit bone resorption, promote the healing of soft tissues, relieve symptoms, reduce postoperative complications and maintain implant stability.ConclusionPCs may be used as an adjuvant therapy in the treatment of lesions on maxillofacial tissues. However, more studies should refine the preparation and treatment methods for platelet concentrates and establish a foundation for their extensive application.https://www.frontiersin.org/articles/10.3389/fbioe.2024.1523225/fullplatelet concentratesplatelet-rich plasmaplatelet-rich fibrinbone regenerationsoft tissue regeneration |
| spellingShingle | Ruijia Liu Siqi Chen Peng Wang Peng Wang Ruiye Bi Ruiye Bi Using platelet concentrates to treat maxillofacial tissue lesions Frontiers in Bioengineering and Biotechnology platelet concentrates platelet-rich plasma platelet-rich fibrin bone regeneration soft tissue regeneration |
| title | Using platelet concentrates to treat maxillofacial tissue lesions |
| title_full | Using platelet concentrates to treat maxillofacial tissue lesions |
| title_fullStr | Using platelet concentrates to treat maxillofacial tissue lesions |
| title_full_unstemmed | Using platelet concentrates to treat maxillofacial tissue lesions |
| title_short | Using platelet concentrates to treat maxillofacial tissue lesions |
| title_sort | using platelet concentrates to treat maxillofacial tissue lesions |
| topic | platelet concentrates platelet-rich plasma platelet-rich fibrin bone regeneration soft tissue regeneration |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1523225/full |
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