FXR Activation Accelerates Early Phase of Osteoblast Differentiation Through COX-2-PGE<sub>2</sub>-EP4 Axis in BMP-2-Induced Mouse Mesenchymal Stem Cells

FXR Activation Accelerates Early Phase of Osteoblast Differentiation Through COX-2-PGE<sub>2</sub>-EP4 Axis in BMP-2-Induced Mouse Mesenchymal Stem Cells

Farnesoid X receptor (FXR), a nuclear receptor, is expressed in calvaria and bone marrow stromal cells and plays a role in bone homeostasis. However, the mechanism of FXR-activated osteoblast differentiation remains unclear. In this study, we investigated the regulatory mechanism underlying FXR-acti...

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Bibliographic Details
Main Authors: Ko Fujimori, Yusuke Iguchi, Yukiko Yamashita, Keigo Gohda, Naoki Teno
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Molecules
Subjects:
mesenchymal stem cells
osteoblasts
FXR
COX-2
PGE<sub>2</sub>
Online Access:https://www.mdpi.com/1420-3049/30/1/58
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