ADA/CD26 axis increases intra-tumor PD-1+CD28+CD8+ T-cell fitness and affects NSCLC prognosis and response to ICB

ADA/CD26 axis increases intra-tumor PD-1+CD28+CD8+ T-cell fitness and affects NSCLC prognosis and response to ICB

Improving cancer immunotherapy efficacy hinges on identifying key T-cell populations critical for tumor control and response to Immune Checkpoint Blockade (ICB). We have recently reported that while the co-expression of PD-1 and CD28 is associated with impaired functionality in peripheral blood, it...

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Bibliographic Details
Main Authors: Ornella Franzese, Belinda Palermo, Giuseppe Frisullo, Mariangela Panetta, Giulia Campo, Daniel D’Andrea, Isabella Sperduti, Riccardo Taje, Paolo Visca, Paola Nisticò
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:OncoImmunology
Subjects:
ADA
CD26
CD28
CD39
CD8+ T cells
Immune checkpoint blockade
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2024.2371051
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