PLEURAL EFFUSION DEVELOPING AS A CONSEQUENCE OF G-CSF ADMINISTRATION IN A PATIENT UNDERGOING AML TREATMENT
Objective: Human granulocyte colony-stimulating factor (G-CSF) plays a vital role in boosting neutrophil production from hematopoietic progenitor cells, both in lab settings and within the human body. Beyond just raising neutrophil counts, G-CSF primes these cells, enhancing their ability to defend...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-12-01
|
| Series: | Hematology, Transfusion and Cell Therapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2531137924028694 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846107626606166016 |
|---|---|
| author | Ali Turunç Birol Güvenç |
| author_facet | Ali Turunç Birol Güvenç |
| author_sort | Ali Turunç |
| collection | DOAJ |
| description | Objective: Human granulocyte colony-stimulating factor (G-CSF) plays a vital role in boosting neutrophil production from hematopoietic progenitor cells, both in lab settings and within the human body. Beyond just raising neutrophil counts, G-CSF primes these cells, enhancing their ability to defend the body, making it a key player not only for neutropenic patients but also for those who are immunocompromised but not necessarily neutropenic. G-CSF is widely used in treating acute myeloid leukemia (AML), either alongside or following chemotherapy. One of its primary benefits is to speed up neutrophil recovery after chemotherapy, reducing both the length of hospital stays and the risk of infection.Here, we share a case involving a 17-year-old male with AML who developed pleural effusion after receiving G-CSF during his cytotoxic treatment. Case Report: The patient, a 17-year-old male, came to our clinic with an elevated white blood cell count and was subsequently diagnosed with acute myeloid leukemia (AML) after a bone marrow aspiration. He was immediately started on the 7+3 induction chemotherapy protocol. During the post-chemotherapy phase, when his neutrophil levels dropped, filgrastim (G-CSF) was introduced to help reduce the risk of infection and shorten the neutropenic period. For the first five days, everything seemed normal, and no side effects were noted. However, after that initial period, the patient began to experience worsening shortness of breath. Imaging revealed a growing pleural effusion on the left side. A diagnostic thoracentesis was performed, and the fluid was drained to provide relief. The analysis confirmed the fluid was transudative, with no signs of infection or malignancy. When the pleural effusion returned, G-CSF was promptly stopped, and the effusion rapidly resolved. After consolidation therapy, G-CSF was reintroduced, and once again, pleural effusion reappeared on the third day of treatment, but this too resolved spontaneously once the G-CSF was discontinued. A pleural biopsy showed no pathological findings, confirming that the G-CSF was likely responsible for the effusion. Discussion: In neutropenic patients, pleural effusion is typically linked to infections, but in this case, no signs of infection or AML involvement were found. The recurring pleural effusion, which resolved after stopping G-CSF, suggests a rare side effect of the treatment. Research indicates that G-CSF may trigger local inflammatory responses, including elevated cytokines like IL-6 and TNF-α, potentially leading to fluid accumulation in the pleura. This case highlights the importance of monitoring for unusual side effects during G-CSF therapy in AML patients. |
| format | Article |
| id | doaj-art-4a2bd4a735694cbab0b57b7d865ebfc9 |
| institution | Kabale University |
| issn | 2531-1379 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Hematology, Transfusion and Cell Therapy |
| spelling | doaj-art-4a2bd4a735694cbab0b57b7d865ebfc92024-12-26T08:57:01ZengElsevierHematology, Transfusion and Cell Therapy2531-13792024-12-0146S41S42PLEURAL EFFUSION DEVELOPING AS A CONSEQUENCE OF G-CSF ADMINISTRATION IN A PATIENT UNDERGOING AML TREATMENTAli Turunç0Birol Güvenç1Cukurova University Medical Faculty Hospital, Department of Internal Medicine, Division of Hematology; Corresponding author.Cukurova University Medical Faculty Hospital, Department of Internal Medicine, Division of HematologyObjective: Human granulocyte colony-stimulating factor (G-CSF) plays a vital role in boosting neutrophil production from hematopoietic progenitor cells, both in lab settings and within the human body. Beyond just raising neutrophil counts, G-CSF primes these cells, enhancing their ability to defend the body, making it a key player not only for neutropenic patients but also for those who are immunocompromised but not necessarily neutropenic. G-CSF is widely used in treating acute myeloid leukemia (AML), either alongside or following chemotherapy. One of its primary benefits is to speed up neutrophil recovery after chemotherapy, reducing both the length of hospital stays and the risk of infection.Here, we share a case involving a 17-year-old male with AML who developed pleural effusion after receiving G-CSF during his cytotoxic treatment. Case Report: The patient, a 17-year-old male, came to our clinic with an elevated white blood cell count and was subsequently diagnosed with acute myeloid leukemia (AML) after a bone marrow aspiration. He was immediately started on the 7+3 induction chemotherapy protocol. During the post-chemotherapy phase, when his neutrophil levels dropped, filgrastim (G-CSF) was introduced to help reduce the risk of infection and shorten the neutropenic period. For the first five days, everything seemed normal, and no side effects were noted. However, after that initial period, the patient began to experience worsening shortness of breath. Imaging revealed a growing pleural effusion on the left side. A diagnostic thoracentesis was performed, and the fluid was drained to provide relief. The analysis confirmed the fluid was transudative, with no signs of infection or malignancy. When the pleural effusion returned, G-CSF was promptly stopped, and the effusion rapidly resolved. After consolidation therapy, G-CSF was reintroduced, and once again, pleural effusion reappeared on the third day of treatment, but this too resolved spontaneously once the G-CSF was discontinued. A pleural biopsy showed no pathological findings, confirming that the G-CSF was likely responsible for the effusion. Discussion: In neutropenic patients, pleural effusion is typically linked to infections, but in this case, no signs of infection or AML involvement were found. The recurring pleural effusion, which resolved after stopping G-CSF, suggests a rare side effect of the treatment. Research indicates that G-CSF may trigger local inflammatory responses, including elevated cytokines like IL-6 and TNF-α, potentially leading to fluid accumulation in the pleura. This case highlights the importance of monitoring for unusual side effects during G-CSF therapy in AML patients.http://www.sciencedirect.com/science/article/pii/S2531137924028694G-CSFAMLpleural effusionneutropeniacytokine response |
| spellingShingle | Ali Turunç Birol Güvenç PLEURAL EFFUSION DEVELOPING AS A CONSEQUENCE OF G-CSF ADMINISTRATION IN A PATIENT UNDERGOING AML TREATMENT Hematology, Transfusion and Cell Therapy G-CSF AML pleural effusion neutropenia cytokine response |
| title | PLEURAL EFFUSION DEVELOPING AS A CONSEQUENCE OF G-CSF ADMINISTRATION IN A PATIENT UNDERGOING AML TREATMENT |
| title_full | PLEURAL EFFUSION DEVELOPING AS A CONSEQUENCE OF G-CSF ADMINISTRATION IN A PATIENT UNDERGOING AML TREATMENT |
| title_fullStr | PLEURAL EFFUSION DEVELOPING AS A CONSEQUENCE OF G-CSF ADMINISTRATION IN A PATIENT UNDERGOING AML TREATMENT |
| title_full_unstemmed | PLEURAL EFFUSION DEVELOPING AS A CONSEQUENCE OF G-CSF ADMINISTRATION IN A PATIENT UNDERGOING AML TREATMENT |
| title_short | PLEURAL EFFUSION DEVELOPING AS A CONSEQUENCE OF G-CSF ADMINISTRATION IN A PATIENT UNDERGOING AML TREATMENT |
| title_sort | pleural effusion developing as a consequence of g csf administration in a patient undergoing aml treatment |
| topic | G-CSF AML pleural effusion neutropenia cytokine response |
| url | http://www.sciencedirect.com/science/article/pii/S2531137924028694 |
| work_keys_str_mv | AT aliturunc pleuraleffusiondevelopingasaconsequenceofgcsfadministrationinapatientundergoingamltreatment AT birolguvenc pleuraleffusiondevelopingasaconsequenceofgcsfadministrationinapatientundergoingamltreatment |