Role of metabolic syndrome and lifestyle factors in endometrial cancer risk and prevention
Introduction: The incidence of endometrial cancer, the sixth most common cancer among women, has been rising, especially in developed countries, possibly due to the obesity and diabetes pandemic. The aim of this review is to investigate the connection between metabolic syndrome, its individual comp...
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| Format: | Article |
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Nicolaus Copernicus University in Toruń
2024-11-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/55862 |
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| author | Anita Kwiatkowska Natalia Małek Sara Emerla Aleksandra Brożyna Arkadiusz Bydliński Konrad Karłowicz Maria Hermanowska Julia Lubomirska Patrycja Figurowska Łukasz Ciulkiewicz |
| author_facet | Anita Kwiatkowska Natalia Małek Sara Emerla Aleksandra Brożyna Arkadiusz Bydliński Konrad Karłowicz Maria Hermanowska Julia Lubomirska Patrycja Figurowska Łukasz Ciulkiewicz |
| author_sort | Anita Kwiatkowska |
| collection | DOAJ |
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Introduction: The incidence of endometrial cancer, the sixth most common cancer among women, has been rising, especially in developed countries, possibly due to the obesity and diabetes pandemic. The aim of this review is to investigate the connection between metabolic syndrome, its individual components and endometrial cancer risk and to explore the role of lifestyle factors in endometrial cancer prevention.
Materials and methods: For this review, we included studies regarding endometrial cancer and metabolic syndrome, obesity, diabetes and hyperglycemia, hypertension, dyslipidemia and several lifestyle factors, from 1994 to 2024.
State of knowledge: This paper reviews existing literature on the relationship between metabolic syndrome and endometrial cancer, highlighting the significant role of central obesity, hyperglycemia and diabetes, dyslipidemia, and hypertension as risk factors. Evidence consistently demonstrates that individuals with metabolic syndrome, and its components individually, are at a heightened risk of developing endometrial cancer compared to those without metabolic abnormalities. Biological mechanisms linking metabolic syndrome’s components to endometrial cancer involve complex interplays between metabolic, hormonal or inflammatory factors and signalling pathways. Lifestyle interventions focusing on weight management, physical activity, and eating habits play an important role in reducing endometrial cancer risk and improving overall health outcomes.
Conclusion: An understanding of the relationship between metabolic syndrome and endometrial cancer is crucial for improving risk stratification, early detection, and prevention strategies. Addressing metabolic abnormalities and promoting healthy lifestyle behaviours are essential actions against the rising incidence and burden of endometrial cancer.
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| format | Article |
| id | doaj-art-49ed9408f2fe409bbe41c829c8667b79 |
| institution | Kabale University |
| issn | 2450-3118 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-49ed9408f2fe409bbe41c829c8667b792024-11-17T08:08:43ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182024-11-013210.12775/QS.2024.32.55862Role of metabolic syndrome and lifestyle factors in endometrial cancer risk and preventionAnita Kwiatkowska0Natalia Małek1Sara Emerla2Aleksandra Brożyna3Arkadiusz Bydliński4Konrad Karłowicz5Maria Hermanowska6Julia Lubomirska7Patrycja Figurowska8Łukasz Ciulkiewicz9Military Institute of Medicine - National Research Institute, Szaserów 128, 04-141 Warsaw, PolandCentral Clinical Hospital in Warsaw, Banacha 1a, 02-097 Warsaw, PolandMedical University of Warsaw, Żwirki i Wigury 61, 02-091 Warsaw, PolandMedical University of Warsaw, Żwirki i Wigury 61, 02-091 Warsaw, Poland Medical University of Warsaw, Żwirki i Wigury 61, 02-091 Warsaw, PolandCentral Clinical Hospital in Warsaw, Banacha 1a, 02-097 Warsaw, PolandJan Kochanowski University, Collegium Medicum, al. IX Wieków Kielc 19A, 25-317 Kielce, PolandJan Kochanowski University, Collegium Medicum, al. IX Wieków Kielc 19A, 25-317 Kielce, PolandIndependent Public Healthcare Center in Mińsk Mazowiecki, Szpitalna 37, 05-300 Mińsk Mazowiecki, PolandProfessor Witold Orlowski Independent Public Clinical Hospital Medical Center of Postgraduate Education, Czerniakowska 231, 00-416 Warsaw, Poland Introduction: The incidence of endometrial cancer, the sixth most common cancer among women, has been rising, especially in developed countries, possibly due to the obesity and diabetes pandemic. The aim of this review is to investigate the connection between metabolic syndrome, its individual components and endometrial cancer risk and to explore the role of lifestyle factors in endometrial cancer prevention. Materials and methods: For this review, we included studies regarding endometrial cancer and metabolic syndrome, obesity, diabetes and hyperglycemia, hypertension, dyslipidemia and several lifestyle factors, from 1994 to 2024. State of knowledge: This paper reviews existing literature on the relationship between metabolic syndrome and endometrial cancer, highlighting the significant role of central obesity, hyperglycemia and diabetes, dyslipidemia, and hypertension as risk factors. Evidence consistently demonstrates that individuals with metabolic syndrome, and its components individually, are at a heightened risk of developing endometrial cancer compared to those without metabolic abnormalities. Biological mechanisms linking metabolic syndrome’s components to endometrial cancer involve complex interplays between metabolic, hormonal or inflammatory factors and signalling pathways. Lifestyle interventions focusing on weight management, physical activity, and eating habits play an important role in reducing endometrial cancer risk and improving overall health outcomes. Conclusion: An understanding of the relationship between metabolic syndrome and endometrial cancer is crucial for improving risk stratification, early detection, and prevention strategies. Addressing metabolic abnormalities and promoting healthy lifestyle behaviours are essential actions against the rising incidence and burden of endometrial cancer. https://apcz.umk.pl/QS/article/view/55862endometrial canermetabolic syndromelifestylepreventionrisk factors |
| spellingShingle | Anita Kwiatkowska Natalia Małek Sara Emerla Aleksandra Brożyna Arkadiusz Bydliński Konrad Karłowicz Maria Hermanowska Julia Lubomirska Patrycja Figurowska Łukasz Ciulkiewicz Role of metabolic syndrome and lifestyle factors in endometrial cancer risk and prevention Quality in Sport endometrial caner metabolic syndrome lifestyle prevention risk factors |
| title | Role of metabolic syndrome and lifestyle factors in endometrial cancer risk and prevention |
| title_full | Role of metabolic syndrome and lifestyle factors in endometrial cancer risk and prevention |
| title_fullStr | Role of metabolic syndrome and lifestyle factors in endometrial cancer risk and prevention |
| title_full_unstemmed | Role of metabolic syndrome and lifestyle factors in endometrial cancer risk and prevention |
| title_short | Role of metabolic syndrome and lifestyle factors in endometrial cancer risk and prevention |
| title_sort | role of metabolic syndrome and lifestyle factors in endometrial cancer risk and prevention |
| topic | endometrial caner metabolic syndrome lifestyle prevention risk factors |
| url | https://apcz.umk.pl/QS/article/view/55862 |
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