The emergence of Sox and POU transcription factors predates the origins of animal stem cells

The emergence of Sox and POU transcription factors predates the origins of animal stem cells

Abstract Stem cells are a hallmark of animal multicellularity. Sox and POU transcription factors are associated with stemness and were believed to be animal innovations, reported absent in their unicellular relatives. Here we describe unicellular Sox and POU factors. Choanoflagellate and filasterean...

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Main Authors: Ya Gao, Daisylyn Senna Tan, Mathias Girbig, Haoqing Hu, Xiaomin Zhou, Qianwen Xie, Shi Wing Yeung, Kin Shing Lee, Sik Yin Ho, Vlad Cojocaru, Jian Yan, Georg K. A. Hochberg, Alex de Mendoza, Ralf Jauch
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54152-x
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