Injectable agents for the induction of Peyronie’s disease in model rats: a comparative study
Peyronie’s disease (PD) is a disorder characterized by fibrous plaque formation in the penile tissue that leads to curvature and complications in advanced stages. In this study, we aimed to compare four injectable induction agents for the establishment of a robust rat model of PD: transforming growt...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Asian Journal of Andrology |
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| Online Access: | https://journals.lww.com/10.4103/aja202430 |
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| author | Guang-Jun Du Si-Yan Xing Ning Wu Tong Wang Yue-Hui Jiang Tao Song Bai-Bing Yang Yu-Tian Dai |
| author_facet | Guang-Jun Du Si-Yan Xing Ning Wu Tong Wang Yue-Hui Jiang Tao Song Bai-Bing Yang Yu-Tian Dai |
| author_sort | Guang-Jun Du |
| collection | DOAJ |
| description | Peyronie’s disease (PD) is a disorder characterized by fibrous plaque formation in the penile tissue that leads to curvature and complications in advanced stages. In this study, we aimed to compare four injectable induction agents for the establishment of a robust rat model of PD: transforming growth factor-β1 (TGF-β1), fibrin, sodium tetradecyl sulfate (STS) combined with TGF-β1, and polidocanol (POL) combined with TGF-β1. The results showed that injection of TGF-β1 or fibrin into the tunica albuginea induced pathological endpoints without causing penile curvature. The STS + TGF-β1 combination resulted in both histological and morphological alterations, but with a high incidence of localized necrosis that led to animal death. The POL + TGF-β1 combination produced pathological changes and curvature comparable to STS + TGF-β1 and led to fewer complications. In conclusion, fibrin, STS + TGF-β1, and POL + TGF-β1 all induced PD with a certain degree of penile curvature and histological fibrosis in rats. The POL + TGF-β1 combination offered comparatively greater safety and clinical relevance and may have the greatest potential for PD research using model rats. |
| format | Article |
| id | doaj-art-49cdc15d7c4a4ed8b82a62029fee8a96 |
| institution | Kabale University |
| issn | 1008-682X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Andrology |
| spelling | doaj-art-49cdc15d7c4a4ed8b82a62029fee8a962025-01-08T07:21:54ZengWolters Kluwer Medknow PublicationsAsian Journal of Andrology1008-682X2025-01-012719610010.4103/aja202430Injectable agents for the induction of Peyronie’s disease in model rats: a comparative studyGuang-Jun DuSi-Yan XingNing WuTong WangYue-Hui JiangTao SongBai-Bing YangYu-Tian DaiPeyronie’s disease (PD) is a disorder characterized by fibrous plaque formation in the penile tissue that leads to curvature and complications in advanced stages. In this study, we aimed to compare four injectable induction agents for the establishment of a robust rat model of PD: transforming growth factor-β1 (TGF-β1), fibrin, sodium tetradecyl sulfate (STS) combined with TGF-β1, and polidocanol (POL) combined with TGF-β1. The results showed that injection of TGF-β1 or fibrin into the tunica albuginea induced pathological endpoints without causing penile curvature. The STS + TGF-β1 combination resulted in both histological and morphological alterations, but with a high incidence of localized necrosis that led to animal death. The POL + TGF-β1 combination produced pathological changes and curvature comparable to STS + TGF-β1 and led to fewer complications. In conclusion, fibrin, STS + TGF-β1, and POL + TGF-β1 all induced PD with a certain degree of penile curvature and histological fibrosis in rats. The POL + TGF-β1 combination offered comparatively greater safety and clinical relevance and may have the greatest potential for PD research using model rats.https://journals.lww.com/10.4103/aja202430fibrinpeyronie’s diseasepolidocanolrat modelsodium tetradecyl sulfatetgf-β1 |
| spellingShingle | Guang-Jun Du Si-Yan Xing Ning Wu Tong Wang Yue-Hui Jiang Tao Song Bai-Bing Yang Yu-Tian Dai Injectable agents for the induction of Peyronie’s disease in model rats: a comparative study Asian Journal of Andrology fibrin peyronie’s disease polidocanol rat model sodium tetradecyl sulfate tgf-β1 |
| title | Injectable agents for the induction of Peyronie’s disease in model rats: a comparative study |
| title_full | Injectable agents for the induction of Peyronie’s disease in model rats: a comparative study |
| title_fullStr | Injectable agents for the induction of Peyronie’s disease in model rats: a comparative study |
| title_full_unstemmed | Injectable agents for the induction of Peyronie’s disease in model rats: a comparative study |
| title_short | Injectable agents for the induction of Peyronie’s disease in model rats: a comparative study |
| title_sort | injectable agents for the induction of peyronie s disease in model rats a comparative study |
| topic | fibrin peyronie’s disease polidocanol rat model sodium tetradecyl sulfate tgf-β1 |
| url | https://journals.lww.com/10.4103/aja202430 |
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