The novel pleuromutilin derivative 22–((4-((4-nitrophenyl)acetamido)phenyl)thio)deoxy pleuromutilin possesses robust anti-mycoplasma activity both in vitro and in vivo

The novel pleuromutilin derivative 22–((4-((4-nitrophenyl)acetamido)phenyl)thio)deoxy pleuromutilin possesses robust anti-mycoplasma activity both in vitro and in vivo

ObjectiveMycoplasmas are structurally simple pathogenic microorganisms that can cause a wide range of diseases in humans and animals and conventional antibiotic therapies of fluoroquinolones and tetracyclines are toxic to young children and young animals and macrolide resistance is increasing. In th...

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Bibliographic Details
Main Authors: Xirui Xia, Xuan Ji, Yaxi Li, Yubo Wang, Yue Zhao, Wenxiang Wang, Huanzhong Ding
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Pharmacology
Subjects:
22-((4-((4-nitrophenyl)acetamido)phenyl)thio)deoxypleuromutilin
pharmacokinetic
pharmacodynamic
Mycoplasma pneumoniae
antibacterial activity
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1491223/full
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