3D Segmentation and Visualization of Skin Vasculature Using Line-Field Confocal Optical Coherence Tomography
This study explores the advanced imaging of skin vasculature using Line-Field Confocal Optical Coherence Tomography (LC-OCT), which offers high-resolution, three-dimensional (3D) visualization of vascular structures, especially within skin tumors. The research aims to improve the understanding of tu...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
|
| Series: | Applied Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3417/15/1/159 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841549439404081152 |
|---|---|
| author | Oliver Mayer Hanna Wirsching Sophia Schlingmann Julia Welzel Sandra Schuh |
| author_facet | Oliver Mayer Hanna Wirsching Sophia Schlingmann Julia Welzel Sandra Schuh |
| author_sort | Oliver Mayer |
| collection | DOAJ |
| description | This study explores the advanced imaging of skin vasculature using Line-Field Confocal Optical Coherence Tomography (LC-OCT), which offers high-resolution, three-dimensional (3D) visualization of vascular structures, especially within skin tumors. The research aims to improve the understanding of tumor angiogenesis and the complex vascular morphology associated with malignancies. The methodology involves converting original image stacks into negative images, manually tracing vessels using the Simple Neurite Tracer (SNT) plugin, and creating smoothed binary masks to reconstruct 3D models. The study’s results highlight the ability to visualize serpiginous, corkscrew-like, and irregular vessels across various skin cancers, including melanoma, squamous cell carcinoma, and basal cell carcinoma. These visualizations provide insights into vessel morphology, spatial arrangements, and blood flow patterns, which are crucial for assessing tumor growth and potential therapeutic responses. The findings indicate that 3D reconstructions from LC-OCT can uncover vascular details previously undetectable by two-dimensional imaging techniques, making it a valuable tool in dermatology for both clinical diagnostics and research. This method allows for better monitoring of skin cancer treatment and understanding of the role of vascular polymorphism in tumor development. |
| format | Article |
| id | doaj-art-499a8087d9b54c92b0d9a440081e6a3a |
| institution | Kabale University |
| issn | 2076-3417 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj-art-499a8087d9b54c92b0d9a440081e6a3a2025-01-10T13:14:39ZengMDPI AGApplied Sciences2076-34172024-12-0115115910.3390/app150101593D Segmentation and Visualization of Skin Vasculature Using Line-Field Confocal Optical Coherence TomographyOliver Mayer0Hanna Wirsching1Sophia Schlingmann2Julia Welzel3Sandra Schuh4Department of Dermatology and Allergology, University Hospital Augsburg, 86179 Augsburg, GermanyDepartment of Dermatology and Allergology, University Hospital Augsburg, 86179 Augsburg, GermanyDepartment of Dermatology and Allergology, University Hospital Augsburg, 86179 Augsburg, GermanyDepartment of Dermatology and Allergology, University Hospital Augsburg, 86179 Augsburg, GermanyDepartment of Dermatology and Allergology, University Hospital Augsburg, 86179 Augsburg, GermanyThis study explores the advanced imaging of skin vasculature using Line-Field Confocal Optical Coherence Tomography (LC-OCT), which offers high-resolution, three-dimensional (3D) visualization of vascular structures, especially within skin tumors. The research aims to improve the understanding of tumor angiogenesis and the complex vascular morphology associated with malignancies. The methodology involves converting original image stacks into negative images, manually tracing vessels using the Simple Neurite Tracer (SNT) plugin, and creating smoothed binary masks to reconstruct 3D models. The study’s results highlight the ability to visualize serpiginous, corkscrew-like, and irregular vessels across various skin cancers, including melanoma, squamous cell carcinoma, and basal cell carcinoma. These visualizations provide insights into vessel morphology, spatial arrangements, and blood flow patterns, which are crucial for assessing tumor growth and potential therapeutic responses. The findings indicate that 3D reconstructions from LC-OCT can uncover vascular details previously undetectable by two-dimensional imaging techniques, making it a valuable tool in dermatology for both clinical diagnostics and research. This method allows for better monitoring of skin cancer treatment and understanding of the role of vascular polymorphism in tumor development.https://www.mdpi.com/2076-3417/15/1/159tumor vesselsline-field confocal optical coherence tomographyskin cancer |
| spellingShingle | Oliver Mayer Hanna Wirsching Sophia Schlingmann Julia Welzel Sandra Schuh 3D Segmentation and Visualization of Skin Vasculature Using Line-Field Confocal Optical Coherence Tomography Applied Sciences tumor vessels line-field confocal optical coherence tomography skin cancer |
| title | 3D Segmentation and Visualization of Skin Vasculature Using Line-Field Confocal Optical Coherence Tomography |
| title_full | 3D Segmentation and Visualization of Skin Vasculature Using Line-Field Confocal Optical Coherence Tomography |
| title_fullStr | 3D Segmentation and Visualization of Skin Vasculature Using Line-Field Confocal Optical Coherence Tomography |
| title_full_unstemmed | 3D Segmentation and Visualization of Skin Vasculature Using Line-Field Confocal Optical Coherence Tomography |
| title_short | 3D Segmentation and Visualization of Skin Vasculature Using Line-Field Confocal Optical Coherence Tomography |
| title_sort | 3d segmentation and visualization of skin vasculature using line field confocal optical coherence tomography |
| topic | tumor vessels line-field confocal optical coherence tomography skin cancer |
| url | https://www.mdpi.com/2076-3417/15/1/159 |
| work_keys_str_mv | AT olivermayer 3dsegmentationandvisualizationofskinvasculatureusinglinefieldconfocalopticalcoherencetomography AT hannawirsching 3dsegmentationandvisualizationofskinvasculatureusinglinefieldconfocalopticalcoherencetomography AT sophiaschlingmann 3dsegmentationandvisualizationofskinvasculatureusinglinefieldconfocalopticalcoherencetomography AT juliawelzel 3dsegmentationandvisualizationofskinvasculatureusinglinefieldconfocalopticalcoherencetomography AT sandraschuh 3dsegmentationandvisualizationofskinvasculatureusinglinefieldconfocalopticalcoherencetomography |