TDP-43 Secretion via Extracellular Vesicles Is Regulated by Macroautophagy

The pathological accumulation of the nuclear protein TDP-43 (TAR DNA-binding protein 43 kDa) in the cytoplasm is characteristic of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD-TDP), and its spread through the brain and spinal cord is closely associated with the pro...

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Bibliographic Details
Main Authors: Yoshinori Tanaka, Shun-ichi Ito, Genjiro Suzuki
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Autophagy Reports
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Online Access:https://www.tandfonline.com/doi/10.1080/27694127.2023.2291250
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