Antiplasmodial activity of flavan derivatives from rootbark of Cassia abbreviata Oliv.
The root bark of Cassia abbreviata has been traditionally used by the native population of the coastal region of Kenya to treat malaria. As part of our ongoing investigations into compounds with activity against malaria parasites, we tested the in vitro antiplasmodial activity against Plasmodium fal...
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Springer
2016-09-01
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| Series: | Journal of Saudi Chemical Society |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319610312001500 |
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| author | David M. Kiplagat Hoseah M. Akala Pamela O. Liyala Julia M. Wangui Rose A.O. Odhiambo Josiah O. Omolo |
| author_facet | David M. Kiplagat Hoseah M. Akala Pamela O. Liyala Julia M. Wangui Rose A.O. Odhiambo Josiah O. Omolo |
| author_sort | David M. Kiplagat |
| collection | DOAJ |
| description | The root bark of Cassia abbreviata has been traditionally used by the native population of the coastal region of Kenya to treat malaria. As part of our ongoing investigations into compounds with activity against malaria parasites, we tested the in vitro antiplasmodial activity against Plasmodium falciparum strain namely; chloroquine-resistant W2 and chloroquine-sensitive D6. The methanolic root extract of the plant was active against the chloroquine-sensitive (IC50 = 20.56 μg/ml) and the chloroquine-resistant (IC50 = 13.31 μg/ml) strains of P. falciparum. Two flavans 1 and 2 were purified, identified and further shown to be antiplasmodial. Compound 2 was more active than compound 1 against both strains of P. falciparum with IC50 values of 8.12 μg/ml (D6); 8.89 μg/ml (W2) and 26.02 μg/ml (D6); 25.97 μg/ml (W2), respectively. This study partly provides evidence to support the use of C. abbreviata as a malaria remedy, as used by the native populations. |
| format | Article |
| id | doaj-art-4988f0cfd2d84a20b76d7c875c5efc7c |
| institution | Kabale University |
| issn | 1319-6103 |
| language | English |
| publishDate | 2016-09-01 |
| publisher | Springer |
| record_format | Article |
| series | Journal of Saudi Chemical Society |
| spelling | doaj-art-4988f0cfd2d84a20b76d7c875c5efc7c2025-08-20T03:49:07ZengSpringerJournal of Saudi Chemical Society1319-61032016-09-0120S1S140S14410.1016/j.jscs.2012.10.002Antiplasmodial activity of flavan derivatives from rootbark of Cassia abbreviata Oliv.David M. Kiplagat0Hoseah M. Akala1Pamela O. Liyala2Julia M. Wangui3Rose A.O. Odhiambo4Josiah O. Omolo5Chemistry Department, Egerton University, P.O. Box 536, 20115 Egerton, KenyaDepartment of Emerging Infectious Diseases (DEID), US Army Medical Research Unit-Kenya (USAMRU-K), Kenya Medical Research Unit, KEMRI-Walter Reed Project, Kenya MRU 64109, APO, AE 09831-4109, USADepartment of Emerging Infectious Diseases (DEID), US Army Medical Research Unit-Kenya (USAMRU-K), Kenya Medical Research Unit, KEMRI-Walter Reed Project, Kenya MRU 64109, APO, AE 09831-4109, USADepartment of Emerging Infectious Diseases (DEID), US Army Medical Research Unit-Kenya (USAMRU-K), Kenya Medical Research Unit, KEMRI-Walter Reed Project, Kenya MRU 64109, APO, AE 09831-4109, USABiological Sciences Department, Egerton University, P.O. Box 536, 20115 Egerton, KenyaChemistry Department, Egerton University, P.O. Box 536, 20115 Egerton, KenyaThe root bark of Cassia abbreviata has been traditionally used by the native population of the coastal region of Kenya to treat malaria. As part of our ongoing investigations into compounds with activity against malaria parasites, we tested the in vitro antiplasmodial activity against Plasmodium falciparum strain namely; chloroquine-resistant W2 and chloroquine-sensitive D6. The methanolic root extract of the plant was active against the chloroquine-sensitive (IC50 = 20.56 μg/ml) and the chloroquine-resistant (IC50 = 13.31 μg/ml) strains of P. falciparum. Two flavans 1 and 2 were purified, identified and further shown to be antiplasmodial. Compound 2 was more active than compound 1 against both strains of P. falciparum with IC50 values of 8.12 μg/ml (D6); 8.89 μg/ml (W2) and 26.02 μg/ml (D6); 25.97 μg/ml (W2), respectively. This study partly provides evidence to support the use of C. abbreviata as a malaria remedy, as used by the native populations.http://www.sciencedirect.com/science/article/pii/S1319610312001500Plasmodium falciparumActive compoundsCassia abbreviataBioassay-guided fractionationChromatography |
| spellingShingle | David M. Kiplagat Hoseah M. Akala Pamela O. Liyala Julia M. Wangui Rose A.O. Odhiambo Josiah O. Omolo Antiplasmodial activity of flavan derivatives from rootbark of Cassia abbreviata Oliv. Journal of Saudi Chemical Society Plasmodium falciparum Active compounds Cassia abbreviata Bioassay-guided fractionation Chromatography |
| title | Antiplasmodial activity of flavan derivatives from rootbark of Cassia abbreviata Oliv. |
| title_full | Antiplasmodial activity of flavan derivatives from rootbark of Cassia abbreviata Oliv. |
| title_fullStr | Antiplasmodial activity of flavan derivatives from rootbark of Cassia abbreviata Oliv. |
| title_full_unstemmed | Antiplasmodial activity of flavan derivatives from rootbark of Cassia abbreviata Oliv. |
| title_short | Antiplasmodial activity of flavan derivatives from rootbark of Cassia abbreviata Oliv. |
| title_sort | antiplasmodial activity of flavan derivatives from rootbark of cassia abbreviata oliv |
| topic | Plasmodium falciparum Active compounds Cassia abbreviata Bioassay-guided fractionation Chromatography |
| url | http://www.sciencedirect.com/science/article/pii/S1319610312001500 |
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