Into the Groove: A Multitechnique Insight into the DNA–Vemurafenib Interaction

Into the Groove: A Multitechnique Insight into the DNA–Vemurafenib Interaction

This study explores the interaction between Vemurafenib (VEM), a potent BRAF inhibitor, and calf thymus DNA (ctDNA) using a comprehensive array of biophysical and computational techniques. The primary objective is to understand the potential off-target effects of VEM on DNA, given its established ro...

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Bibliographic Details
Main Authors: Gabriele Cavalieri, Riccardo Pison, Domenico Marson, Erik Laurini, Sabrina Pricl
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Applied Biosciences
Subjects:
vemurafenib
calf thymus DNA
spectroscopic techniques
molecular simulations
binding affinity
Online Access:https://www.mdpi.com/2813-0464/3/4/30
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