iPSC-Derived Biological Pacemaker—From Bench to Bedside
Induced pluripotent stem cell (iPSC)-derived biological pacemakers have emerged as an alternative to traditional electronic pacemakers for managing cardiac arrhythmias. While effective, electronic pacemakers face challenges such as device failure, lead complications, and surgical risks, particularly...
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MDPI AG
2024-12-01
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| Online Access: | https://www.mdpi.com/2073-4409/13/24/2045 |
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| author | Quan Duy Vo Kazufumi Nakamura Yukihiro Saito Toshihiro Iida Masashi Yoshida Naofumi Amioka Satoshi Akagi Toru Miyoshi Shinsuke Yuasa |
| author_facet | Quan Duy Vo Kazufumi Nakamura Yukihiro Saito Toshihiro Iida Masashi Yoshida Naofumi Amioka Satoshi Akagi Toru Miyoshi Shinsuke Yuasa |
| author_sort | Quan Duy Vo |
| collection | DOAJ |
| description | Induced pluripotent stem cell (iPSC)-derived biological pacemakers have emerged as an alternative to traditional electronic pacemakers for managing cardiac arrhythmias. While effective, electronic pacemakers face challenges such as device failure, lead complications, and surgical risks, particularly in children. iPSC-derived pacemakers offer a promising solution by mimicking the sinoatrial node’s natural pacemaking function, providing a more physiological approach to rhythm control. These cells can differentiate into cardiomyocytes capable of autonomous electrical activity, integrating into heart tissue. However, challenges such as achieving cellular maturity, long-term functionality, and immune response remain significant barriers to clinical translation. Future research should focus on refining gene-editing techniques, optimizing differentiation, and developing scalable production processes to enhance the safety and effectiveness of these biological pacemakers. With further advancements, iPSC-derived pacemakers could offer a patient-specific, durable alternative for cardiac rhythm management. This review discusses key advancements in differentiation protocols and preclinical studies, demonstrating their potential in treating dysrhythmias. |
| format | Article |
| id | doaj-art-495a812115f342df8d824d1b8e9e18ad |
| institution | Kabale University |
| issn | 2073-4409 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-495a812115f342df8d824d1b8e9e18ad2024-12-27T14:16:26ZengMDPI AGCells2073-44092024-12-011324204510.3390/cells13242045iPSC-Derived Biological Pacemaker—From Bench to BedsideQuan Duy Vo0Kazufumi Nakamura1Yukihiro Saito2Toshihiro Iida3Masashi Yoshida4Naofumi Amioka5Satoshi Akagi6Toru Miyoshi7Shinsuke Yuasa8Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, JapanDepartment of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, JapanDepartment of Cardiovascular Medicine, Okayama University Hospital, Okayama 700-8558, JapanDepartment of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, JapanDepartment of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, JapanDepartment of Cardiovascular Medicine, Okayama University Hospital, Okayama 700-8558, JapanDepartment of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, JapanDepartment of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, JapanDepartment of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, JapanInduced pluripotent stem cell (iPSC)-derived biological pacemakers have emerged as an alternative to traditional electronic pacemakers for managing cardiac arrhythmias. While effective, electronic pacemakers face challenges such as device failure, lead complications, and surgical risks, particularly in children. iPSC-derived pacemakers offer a promising solution by mimicking the sinoatrial node’s natural pacemaking function, providing a more physiological approach to rhythm control. These cells can differentiate into cardiomyocytes capable of autonomous electrical activity, integrating into heart tissue. However, challenges such as achieving cellular maturity, long-term functionality, and immune response remain significant barriers to clinical translation. Future research should focus on refining gene-editing techniques, optimizing differentiation, and developing scalable production processes to enhance the safety and effectiveness of these biological pacemakers. With further advancements, iPSC-derived pacemakers could offer a patient-specific, durable alternative for cardiac rhythm management. This review discusses key advancements in differentiation protocols and preclinical studies, demonstrating their potential in treating dysrhythmias.https://www.mdpi.com/2073-4409/13/24/2045sinoatrial nodeHCN channelsinduced pluripotent stem cell |
| spellingShingle | Quan Duy Vo Kazufumi Nakamura Yukihiro Saito Toshihiro Iida Masashi Yoshida Naofumi Amioka Satoshi Akagi Toru Miyoshi Shinsuke Yuasa iPSC-Derived Biological Pacemaker—From Bench to Bedside Cells sinoatrial node HCN channels induced pluripotent stem cell |
| title | iPSC-Derived Biological Pacemaker—From Bench to Bedside |
| title_full | iPSC-Derived Biological Pacemaker—From Bench to Bedside |
| title_fullStr | iPSC-Derived Biological Pacemaker—From Bench to Bedside |
| title_full_unstemmed | iPSC-Derived Biological Pacemaker—From Bench to Bedside |
| title_short | iPSC-Derived Biological Pacemaker—From Bench to Bedside |
| title_sort | ipsc derived biological pacemaker from bench to bedside |
| topic | sinoatrial node HCN channels induced pluripotent stem cell |
| url | https://www.mdpi.com/2073-4409/13/24/2045 |
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