Advancements in Research on Non-AR- Signaling Pathways and Targeted Therapies for Castration-Resistant Prostate Cancer
Prostate cancer (Pca) is a significant malignancy affecting men's health, with its incidence steadily increasing worldwide in recent years. Among its various subtypes, castration-resistant prostate cancer (CRPC) holds particular importance due to its pivotal role in the progression and manageme...
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| Format: | Article |
| Language: | English |
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Asian Medical Press Ltd.(H.K.)
2025-01-01
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| Series: | Annals of Urologic Oncology |
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| Online Access: | http://auo.asmepress.com/articles/new-93-620.html |
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| author | Haq Dad Asger Hansen |
| author_facet | Haq Dad Asger Hansen |
| author_sort | Haq Dad |
| collection | DOAJ |
| description | Prostate cancer (Pca) is a significant malignancy affecting men's health, with its incidence steadily increasing worldwide in recent years. Among its various subtypes, castration-resistant prostate cancer (CRPC) holds particular importance due to its pivotal role in the progression and management of Pca. The treatment options for Pca range from surgery to medication. However, the mechanisms underlying CRPC remain complex, with abnormal signal transduction pathways identified as a key factor in its development and progression. While the androgen receptor (AR) signaling pathway is widely recognized as central to CRPC pathogenesis, emerging research highlights the critical involvement of the non-AR signaling pathway in the disease. Prominent pathways in the disease include PI3K-Akt-mTOR, Wnt, Hippo, Hedgehog, Notch, HOXB13, and Jak2-Stat5a/b. Understanding the interplay between non-AR signaling pathways is vital for advancing therapeutic strategies for Pca. This work provides a comprehensive review of recent research progress on the relationship between non-AR signaling pathways and CRPC, aiming to offer insights and guidance for future research. |
| format | Article |
| id | doaj-art-4940343d511247d79cbc68a42ed52159 |
| institution | Kabale University |
| issn | 2617-7765 2617-7773 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Asian Medical Press Ltd.(H.K.) |
| record_format | Article |
| series | Annals of Urologic Oncology |
| spelling | doaj-art-4940343d511247d79cbc68a42ed521592025-01-05T07:06:00ZengAsian Medical Press Ltd.(H.K.)Annals of Urologic Oncology2617-77652617-77732025-01-018Advancements in Research on Non-AR- Signaling Pathways and Targeted Therapies for Castration-Resistant Prostate CancerHaq Dad 0Asger Hansen1Department of Biomedical Science, University of Bergen, Bergen 5020, Norway.Department of Biomedical Science, University of Bergen, Bergen 5020, Norway.Prostate cancer (Pca) is a significant malignancy affecting men's health, with its incidence steadily increasing worldwide in recent years. Among its various subtypes, castration-resistant prostate cancer (CRPC) holds particular importance due to its pivotal role in the progression and management of Pca. The treatment options for Pca range from surgery to medication. However, the mechanisms underlying CRPC remain complex, with abnormal signal transduction pathways identified as a key factor in its development and progression. While the androgen receptor (AR) signaling pathway is widely recognized as central to CRPC pathogenesis, emerging research highlights the critical involvement of the non-AR signaling pathway in the disease. Prominent pathways in the disease include PI3K-Akt-mTOR, Wnt, Hippo, Hedgehog, Notch, HOXB13, and Jak2-Stat5a/b. Understanding the interplay between non-AR signaling pathways is vital for advancing therapeutic strategies for Pca. This work provides a comprehensive review of recent research progress on the relationship between non-AR signaling pathways and CRPC, aiming to offer insights and guidance for future research.http://auo.asmepress.com/articles/new-93-620.htmlprostate cancerandrogen receptorsignal transductioncastration-resistant prostate cancer |
| spellingShingle | Haq Dad Asger Hansen Advancements in Research on Non-AR- Signaling Pathways and Targeted Therapies for Castration-Resistant Prostate Cancer Annals of Urologic Oncology prostate cancer androgen receptor signal transduction castration-resistant prostate cancer |
| title | Advancements in Research on Non-AR- Signaling Pathways and Targeted Therapies for Castration-Resistant Prostate Cancer |
| title_full | Advancements in Research on Non-AR- Signaling Pathways and Targeted Therapies for Castration-Resistant Prostate Cancer |
| title_fullStr | Advancements in Research on Non-AR- Signaling Pathways and Targeted Therapies for Castration-Resistant Prostate Cancer |
| title_full_unstemmed | Advancements in Research on Non-AR- Signaling Pathways and Targeted Therapies for Castration-Resistant Prostate Cancer |
| title_short | Advancements in Research on Non-AR- Signaling Pathways and Targeted Therapies for Castration-Resistant Prostate Cancer |
| title_sort | advancements in research on non ar signaling pathways and targeted therapies for castration resistant prostate cancer |
| topic | prostate cancer androgen receptor signal transduction castration-resistant prostate cancer |
| url | http://auo.asmepress.com/articles/new-93-620.html |
| work_keys_str_mv | AT haqdad advancementsinresearchonnonarsignalingpathwaysandtargetedtherapiesforcastrationresistantprostatecancer AT asgerhansen advancementsinresearchonnonarsignalingpathwaysandtargetedtherapiesforcastrationresistantprostatecancer |