The therapeutic potential of targeting Oncostatin M and the interleukin-6 family in retinal diseases: A comprehensive review
Retinal diseases, which can lead to significant vision loss, are complex conditions involving various cellular and molecular mechanisms. The interleukin-6 (IL-6) family, particularly Oncostatin M (OSM), has garnered attention for their roles in retinal inflammation, angiogenesis, and neuroprotection...
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| Format: | Article |
| Language: | English |
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De Gruyter
2024-12-01
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| Series: | Open Life Sciences |
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| Online Access: | https://doi.org/10.1515/biol-2022-1023 |
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| author | Mori Tommaso Nagaraj Nareshkumar Ragavachetty Surico Pier Luigi Zhou Wenjing Parmar Uday Pratap Singh D’Esposito Fabiana Gagliano Caterina Musa Mutali Zeppieri Marco |
| author_facet | Mori Tommaso Nagaraj Nareshkumar Ragavachetty Surico Pier Luigi Zhou Wenjing Parmar Uday Pratap Singh D’Esposito Fabiana Gagliano Caterina Musa Mutali Zeppieri Marco |
| author_sort | Mori Tommaso |
| collection | DOAJ |
| description | Retinal diseases, which can lead to significant vision loss, are complex conditions involving various cellular and molecular mechanisms. The interleukin-6 (IL-6) family, particularly Oncostatin M (OSM), has garnered attention for their roles in retinal inflammation, angiogenesis, and neuroprotection. This comprehensive review explores the dual nature of OSM and other IL-6 family members in retinal pathophysiology, highlighting their contribution to both degenerative and regenerative processes. The review also examines current research on OSM’s interaction with key signaling pathways and discusses the potential of OSM and the IL-6 family as potential therapeutic targets. Understanding these mechanisms could lead to innovative treatments that modulate OSM activity, offering new avenues for managing retinal diseases and contributing to the development of more effective interventions. |
| format | Article |
| id | doaj-art-4900d2af78d34d3ebdc0b1fd7e9aeb90 |
| institution | Kabale University |
| issn | 2391-5412 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Life Sciences |
| spelling | doaj-art-4900d2af78d34d3ebdc0b1fd7e9aeb902025-01-07T07:55:33ZengDe GruyterOpen Life Sciences2391-54122024-12-01191e1061610.1515/biol-2022-1023The therapeutic potential of targeting Oncostatin M and the interleukin-6 family in retinal diseases: A comprehensive reviewMori Tommaso0Nagaraj Nareshkumar Ragavachetty1Surico Pier Luigi2Zhou Wenjing3Parmar Uday Pratap Singh4D’Esposito Fabiana5Gagliano Caterina6Musa Mutali7Zeppieri Marco8Department of Pathology, University of California, San Diego, La Jolla, CA, 92093, United States of AmericaDepartment of Pathology, University of California, San Diego, La Jolla, CA, 92093, United States of AmericaDepartment of Ophthalmology, Campus Bio-Medico University Hospital, Rome, 00128, ItalyDepartment of Pathology, University of California, San Diego, La Jolla, CA, 92093, United States of AmericaSchepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA, 02114, United States of AmericaImperial College Ophthalmic Research Group (ICORG) Unit, Imperial College, London, NW1 5QH, United KingdomDepartment of Medicine and Surgery, University of Enna “Kore”, Piazza dell’Università, 94100, Enna, EN, ItalyDepartment of Optometry, University of Benin, Benin City, 300238, Edo State, NigeriaDepartment of Ophthalmology, University Hospital of Udine, p.le S. Maria della Misericordia 15, 33100, Udine, ItalyRetinal diseases, which can lead to significant vision loss, are complex conditions involving various cellular and molecular mechanisms. The interleukin-6 (IL-6) family, particularly Oncostatin M (OSM), has garnered attention for their roles in retinal inflammation, angiogenesis, and neuroprotection. This comprehensive review explores the dual nature of OSM and other IL-6 family members in retinal pathophysiology, highlighting their contribution to both degenerative and regenerative processes. The review also examines current research on OSM’s interaction with key signaling pathways and discusses the potential of OSM and the IL-6 family as potential therapeutic targets. Understanding these mechanisms could lead to innovative treatments that modulate OSM activity, offering new avenues for managing retinal diseases and contributing to the development of more effective interventions.https://doi.org/10.1515/biol-2022-1023oncostatin mretinal diseasesil-6 familycytokine modulationtherapeutic targets |
| spellingShingle | Mori Tommaso Nagaraj Nareshkumar Ragavachetty Surico Pier Luigi Zhou Wenjing Parmar Uday Pratap Singh D’Esposito Fabiana Gagliano Caterina Musa Mutali Zeppieri Marco The therapeutic potential of targeting Oncostatin M and the interleukin-6 family in retinal diseases: A comprehensive review Open Life Sciences oncostatin m retinal diseases il-6 family cytokine modulation therapeutic targets |
| title | The therapeutic potential of targeting Oncostatin M and the interleukin-6 family in retinal diseases: A comprehensive review |
| title_full | The therapeutic potential of targeting Oncostatin M and the interleukin-6 family in retinal diseases: A comprehensive review |
| title_fullStr | The therapeutic potential of targeting Oncostatin M and the interleukin-6 family in retinal diseases: A comprehensive review |
| title_full_unstemmed | The therapeutic potential of targeting Oncostatin M and the interleukin-6 family in retinal diseases: A comprehensive review |
| title_short | The therapeutic potential of targeting Oncostatin M and the interleukin-6 family in retinal diseases: A comprehensive review |
| title_sort | therapeutic potential of targeting oncostatin m and the interleukin 6 family in retinal diseases a comprehensive review |
| topic | oncostatin m retinal diseases il-6 family cytokine modulation therapeutic targets |
| url | https://doi.org/10.1515/biol-2022-1023 |
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