Drug treatment strategies for secondary lymphedema
Secondary lymphedema is a chronic disease caused by lymphatic system dysfunction, which affects about 140 to 250 million people worldwide and has the second highest incidence among disabling diseases. With the advancement of malignant tumor treatment technology and the acceleration of the aging proc...
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| Format: | Article |
| Language: | zho |
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Editorial Office of International Journal of Geriatrics
2025-07-01
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| Series: | Guoji laonian yixue zazhi |
| Subjects: | |
| Online Access: | http://gwll.publish.founderss.cn/thesisDetails#10.3969/j.issn.1674-7593.2025.04.001&lang=en |
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| _version_ | 1849318543967911936 |
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| author | Fu Yongda Duan Man Pu Luya Du Jianshi |
| author_facet | Fu Yongda Duan Man Pu Luya Du Jianshi |
| author_sort | Fu Yongda |
| collection | DOAJ |
| description | Secondary lymphedema is a chronic disease caused by lymphatic system dysfunction, which affects about 140 to 250 million people worldwide and has the second highest incidence among disabling diseases. With the advancement of malignant tumor treatment technology and the acceleration of the aging process of the population, the incidence of the disease continues to rise. Elderly patients present particular clinical challenges due to age-related lymphatic degeneration, diminished tissue regeneration, and frequent comorbidities. Current therapeutic strategies encompass surgical interventions, complex decongestive therapy, and pharmacotherapy with surgical options offering limited symptomatic relief despite their invasive nature, while complex decongestive therapy proves challenging for elderly patients due to its prolonged duration and modest efficacy. Pharmacotherapy has emerged as a particularly advantageous approach for geriatric populations, combining convenience with favorable safety profiles. Recent breakthroughs in understanding disease mechanisms have identified novel drug candidates that promote lymphatic regeneration through multiple pathways: targeting inflammatory responses, modulating immune microenvironments, stimulating lymphangiogenesis, and inhibiting fibrosis. These multimodal agents offer both symptomatic relief and pathological improvement, presenting new opportunities for developing personalized treatment regimens that balance efficacy and safety for elderly patients. This review systematically evaluates promising pharmacological agents and their mechanisms, with special emphasis on addressing the unique therapeutic needs of aging populations, aiming to advance treatment strategies from symptom control to causative therapy. |
| format | Article |
| id | doaj-art-48fe2b14c3e6442bbf1ae88e836eb1a3 |
| institution | Kabale University |
| issn | 1674-7593 |
| language | zho |
| publishDate | 2025-07-01 |
| publisher | Editorial Office of International Journal of Geriatrics |
| record_format | Article |
| series | Guoji laonian yixue zazhi |
| spelling | doaj-art-48fe2b14c3e6442bbf1ae88e836eb1a32025-08-20T03:50:48ZzhoEditorial Office of International Journal of GeriatricsGuoji laonian yixue zazhi1674-75932025-07-0146438539110.3969/j.issn.1674-7593.2025.04.001Drug treatment strategies for secondary lymphedemaFu Yongda0Duan Man1Pu Luya2Du Jianshi3Department of Vascular Surgery, China-Japan Union Hospital of Jilin University, Changchun 130021Department of Vascular Surgery, China-Japan Union Hospital of Jilin University, Changchun 130021Department of Vascular Surgery, China-Japan Union Hospital of Jilin University, Changchun 130021Department of Vascular Surgery, China-Japan Union Hospital of Jilin University, Changchun 130021Secondary lymphedema is a chronic disease caused by lymphatic system dysfunction, which affects about 140 to 250 million people worldwide and has the second highest incidence among disabling diseases. With the advancement of malignant tumor treatment technology and the acceleration of the aging process of the population, the incidence of the disease continues to rise. Elderly patients present particular clinical challenges due to age-related lymphatic degeneration, diminished tissue regeneration, and frequent comorbidities. Current therapeutic strategies encompass surgical interventions, complex decongestive therapy, and pharmacotherapy with surgical options offering limited symptomatic relief despite their invasive nature, while complex decongestive therapy proves challenging for elderly patients due to its prolonged duration and modest efficacy. Pharmacotherapy has emerged as a particularly advantageous approach for geriatric populations, combining convenience with favorable safety profiles. Recent breakthroughs in understanding disease mechanisms have identified novel drug candidates that promote lymphatic regeneration through multiple pathways: targeting inflammatory responses, modulating immune microenvironments, stimulating lymphangiogenesis, and inhibiting fibrosis. These multimodal agents offer both symptomatic relief and pathological improvement, presenting new opportunities for developing personalized treatment regimens that balance efficacy and safety for elderly patients. This review systematically evaluates promising pharmacological agents and their mechanisms, with special emphasis on addressing the unique therapeutic needs of aging populations, aiming to advance treatment strategies from symptom control to causative therapy.http://gwll.publish.founderss.cn/thesisDetails#10.3969/j.issn.1674-7593.2025.04.001&lang=ensecondary lymphedemadrug therapylymphangiogenesisimmunomodulationanti-fibrotic therapy |
| spellingShingle | Fu Yongda Duan Man Pu Luya Du Jianshi Drug treatment strategies for secondary lymphedema Guoji laonian yixue zazhi secondary lymphedema drug therapy lymphangiogenesis immunomodulation anti-fibrotic therapy |
| title | Drug treatment strategies for secondary lymphedema |
| title_full | Drug treatment strategies for secondary lymphedema |
| title_fullStr | Drug treatment strategies for secondary lymphedema |
| title_full_unstemmed | Drug treatment strategies for secondary lymphedema |
| title_short | Drug treatment strategies for secondary lymphedema |
| title_sort | drug treatment strategies for secondary lymphedema |
| topic | secondary lymphedema drug therapy lymphangiogenesis immunomodulation anti-fibrotic therapy |
| url | http://gwll.publish.founderss.cn/thesisDetails#10.3969/j.issn.1674-7593.2025.04.001&lang=en |
| work_keys_str_mv | AT fuyongda drugtreatmentstrategiesforsecondarylymphedema AT duanman drugtreatmentstrategiesforsecondarylymphedema AT puluya drugtreatmentstrategiesforsecondarylymphedema AT dujianshi drugtreatmentstrategiesforsecondarylymphedema |