Ambient air pollution and thyroid function in Spanish adults. A nationwide population-based study (Di@bet.es study)
Abstract Background Recent reports have suggested that air pollution may impact thyroid function, although the evidence is still scarce and inconclusive. In this study we evaluated the association of exposure to air pollutants to thyroid function parameters in a nationwide sample representative of t...
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2022-08-01
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| Series: | Environmental Health |
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| Online Access: | https://doi.org/10.1186/s12940-022-00889-1 |
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| author | Sergio Valdés Viyey Doulatram-Gamgaram Cristina Maldonado-Araque Ana Lago-Sampedro Eva García-Escobar Sara García-Serrano Marta García-Vivanco Luis Garrido Juan Mark Richard Theobald Victoria Gil Fernando Martín-Llorente Pilar Ocon Alfonso Calle-Pascual Luis Castaño Elías Delgado Edelmiro Menendez Josep Franch-Nadal Sonia Gaztambide Joan Girbés F Javier Chaves José L Galán-García Gabriel Aguilera-Venegas Carolina Gutierrez-Repiso José Carlos Fernández-García Natalia Colomo Federico Soriguer Eduardo García-Fuentes Gemma Rojo-Martínez |
| author_facet | Sergio Valdés Viyey Doulatram-Gamgaram Cristina Maldonado-Araque Ana Lago-Sampedro Eva García-Escobar Sara García-Serrano Marta García-Vivanco Luis Garrido Juan Mark Richard Theobald Victoria Gil Fernando Martín-Llorente Pilar Ocon Alfonso Calle-Pascual Luis Castaño Elías Delgado Edelmiro Menendez Josep Franch-Nadal Sonia Gaztambide Joan Girbés F Javier Chaves José L Galán-García Gabriel Aguilera-Venegas Carolina Gutierrez-Repiso José Carlos Fernández-García Natalia Colomo Federico Soriguer Eduardo García-Fuentes Gemma Rojo-Martínez |
| author_sort | Sergio Valdés |
| collection | DOAJ |
| description | Abstract Background Recent reports have suggested that air pollution may impact thyroid function, although the evidence is still scarce and inconclusive. In this study we evaluated the association of exposure to air pollutants to thyroid function parameters in a nationwide sample representative of the adult population of Spain. Methods The Di@bet.es study is a national, cross-sectional, population-based survey which was conducted in 2008-2010 using a random cluster sampling of the Spanish population. The present analyses included 3859 individuals, without a previous thyroid disease diagnosis, and with negative thyroid peroxidase antibodies (TPO Abs) and thyroid-stimulating hormone (TSH) levels of 0.1-20 mIU/L. Participants were assigned air pollution concentrations for particulate matter <2.5μm (PM2.5) and Nitrogen Dioxide (NO2), corresponding to the health examination year, obtained by means of modeling combined with measurements taken at air quality stations (CHIMERE chemistry-transport model). TSH, free thyroxine (FT4), free triiodothyronine (FT3) and TPO Abs concentrations were analyzed using an electrochemiluminescence immunoassay (Modular Analytics E170 Roche). Results In multivariate linear regression models, there was a highly significant negative correlation between PM2.5 concentrations and both FT4 (p<0.001), and FT3 levels (p<0.001). In multivariate logistic regression, there was a significant association between PM2.5 concentrations and the odds of presenting high TSH [OR 1.24 (1.01-1.52) p=0.043], lower FT4 [OR 1.25 (1.02-1.54) p=0.032] and low FT3 levels [1.48 (1.19-1.84) p=<0.001] per each IQR increase in PM2.5 (4.86 μg/m3). There was no association between NO2 concentrations and thyroid hormone levels. No significant heterogeneity was seen in the results between groups of men, pre-menopausal and post-menopausal women. Conclusions Exposures to PM2.5 in the general population were associated with mild alterations in thyroid function. |
| format | Article |
| id | doaj-art-48cda3b2278d4b4d9b3e37d83fb48ab0 |
| institution | Kabale University |
| issn | 1476-069X |
| language | English |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Environmental Health |
| spelling | doaj-art-48cda3b2278d4b4d9b3e37d83fb48ab02025-08-20T03:37:41ZengBMCEnvironmental Health1476-069X2022-08-012111810.1186/s12940-022-00889-1Ambient air pollution and thyroid function in Spanish adults. A nationwide population-based study (Di@bet.es study)Sergio Valdés0Viyey Doulatram-Gamgaram1Cristina Maldonado-Araque2Ana Lago-Sampedro3Eva García-Escobar4Sara García-Serrano5Marta García-Vivanco6Luis Garrido Juan7Mark Richard Theobald8Victoria Gil9Fernando Martín-Llorente10Pilar Ocon11Alfonso Calle-Pascual12Luis Castaño13Elías Delgado14Edelmiro Menendez15Josep Franch-Nadal16Sonia Gaztambide17Joan Girbés18F Javier Chaves19José L Galán-García20Gabriel Aguilera-Venegas21Carolina Gutierrez-Repiso22José Carlos Fernández-García23Natalia Colomo24Federico Soriguer25Eduardo García-Fuentes26Gemma Rojo-Martínez27Department of Endocrinology and Nutrition, Hospital Regional Universitario de Málaga/Universidad de Málaga, Instituto de Investigación Biomedica de Málaga-IBIMADepartment of Endocrinology and Nutrition, Hospital Regional Universitario de Málaga/Universidad de Málaga, Instituto de Investigación Biomedica de Málaga-IBIMADepartment of Endocrinology and Nutrition, Hospital Regional Universitario de Málaga/Universidad de Málaga, Instituto de Investigación Biomedica de Málaga-IBIMADepartment of Endocrinology and Nutrition, Hospital Regional Universitario de Málaga/Universidad de Málaga, Instituto de Investigación Biomedica de Málaga-IBIMADepartment of Endocrinology and Nutrition, Hospital Regional Universitario de Málaga/Universidad de Málaga, Instituto de Investigación Biomedica de Málaga-IBIMADepartment of Endocrinology and Nutrition, Hospital Regional Universitario de Málaga/Universidad de Málaga, Instituto de Investigación Biomedica de Málaga-IBIMACentro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT) - División de Contaminación AtmosféricaCentro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT) - División de Contaminación AtmosféricaCentro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT) - División de Contaminación AtmosféricaCentro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT) - División de Contaminación AtmosféricaCentro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT) - División de Contaminación AtmosféricaUGC de Laboratorio (Bioquímica), Hospital Regional Universitario de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA)Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos IIICentro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos IIIDepartment of Endocrinology and Nutrition, Hospital Universitario Central de Asturias / University of Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA)Department of Endocrinology and Nutrition, Hospital Universitario Central de Asturias / University of Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA)Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos IIICentro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos IIIGenomic Studies and Genetic Diagnosis Unit, Fundación de Investigación del Hospital Clínico de Valencia - INCLIVACentro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos IIIDepartment of Applied Mathematics, University of MálagaDepartment of Applied Mathematics, University of MálagaUGC de Endocrinología y Nutrición. Hospital Universitario Virgen de la Victoria, Instituto de Investigación Biomedica de Málaga-IBIMADepartment of Endocrinology and Nutrition, Hospital Regional Universitario de Málaga/Universidad de Málaga, Instituto de Investigación Biomedica de Málaga-IBIMADepartment of Endocrinology and Nutrition, Hospital Regional Universitario de Málaga/Universidad de Málaga, Instituto de Investigación Biomedica de Málaga-IBIMAMálaga Academy of SciencesUnidad de Gestión Clínica de Aparato Digestivo, Hospital Universitario Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga - IBIMADepartment of Endocrinology and Nutrition, Hospital Regional Universitario de Málaga/Universidad de Málaga, Instituto de Investigación Biomedica de Málaga-IBIMAAbstract Background Recent reports have suggested that air pollution may impact thyroid function, although the evidence is still scarce and inconclusive. In this study we evaluated the association of exposure to air pollutants to thyroid function parameters in a nationwide sample representative of the adult population of Spain. Methods The Di@bet.es study is a national, cross-sectional, population-based survey which was conducted in 2008-2010 using a random cluster sampling of the Spanish population. The present analyses included 3859 individuals, without a previous thyroid disease diagnosis, and with negative thyroid peroxidase antibodies (TPO Abs) and thyroid-stimulating hormone (TSH) levels of 0.1-20 mIU/L. Participants were assigned air pollution concentrations for particulate matter <2.5μm (PM2.5) and Nitrogen Dioxide (NO2), corresponding to the health examination year, obtained by means of modeling combined with measurements taken at air quality stations (CHIMERE chemistry-transport model). TSH, free thyroxine (FT4), free triiodothyronine (FT3) and TPO Abs concentrations were analyzed using an electrochemiluminescence immunoassay (Modular Analytics E170 Roche). Results In multivariate linear regression models, there was a highly significant negative correlation between PM2.5 concentrations and both FT4 (p<0.001), and FT3 levels (p<0.001). In multivariate logistic regression, there was a significant association between PM2.5 concentrations and the odds of presenting high TSH [OR 1.24 (1.01-1.52) p=0.043], lower FT4 [OR 1.25 (1.02-1.54) p=0.032] and low FT3 levels [1.48 (1.19-1.84) p=<0.001] per each IQR increase in PM2.5 (4.86 μg/m3). There was no association between NO2 concentrations and thyroid hormone levels. No significant heterogeneity was seen in the results between groups of men, pre-menopausal and post-menopausal women. Conclusions Exposures to PM2.5 in the general population were associated with mild alterations in thyroid function.https://doi.org/10.1186/s12940-022-00889-1Air pollutionThyroidSpain |
| spellingShingle | Sergio Valdés Viyey Doulatram-Gamgaram Cristina Maldonado-Araque Ana Lago-Sampedro Eva García-Escobar Sara García-Serrano Marta García-Vivanco Luis Garrido Juan Mark Richard Theobald Victoria Gil Fernando Martín-Llorente Pilar Ocon Alfonso Calle-Pascual Luis Castaño Elías Delgado Edelmiro Menendez Josep Franch-Nadal Sonia Gaztambide Joan Girbés F Javier Chaves José L Galán-García Gabriel Aguilera-Venegas Carolina Gutierrez-Repiso José Carlos Fernández-García Natalia Colomo Federico Soriguer Eduardo García-Fuentes Gemma Rojo-Martínez Ambient air pollution and thyroid function in Spanish adults. A nationwide population-based study (Di@bet.es study) Environmental Health Air pollution Thyroid Spain |
| title | Ambient air pollution and thyroid function in Spanish adults. A nationwide population-based study (Di@bet.es study) |
| title_full | Ambient air pollution and thyroid function in Spanish adults. A nationwide population-based study (Di@bet.es study) |
| title_fullStr | Ambient air pollution and thyroid function in Spanish adults. A nationwide population-based study (Di@bet.es study) |
| title_full_unstemmed | Ambient air pollution and thyroid function in Spanish adults. A nationwide population-based study (Di@bet.es study) |
| title_short | Ambient air pollution and thyroid function in Spanish adults. A nationwide population-based study (Di@bet.es study) |
| title_sort | ambient air pollution and thyroid function in spanish adults a nationwide population based study di bet es study |
| topic | Air pollution Thyroid Spain |
| url | https://doi.org/10.1186/s12940-022-00889-1 |
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