Low molecular weight chitosan (∼20 kDa) exhibits in vivo anti-hyperglycemic effects through AKT/PI3K/FOXO pathway
Diabetes, a metabolic syndrome, is a leading global cause of morbidity and mortality. Dietary polysaccharide intervention besides medication, helps in diabetes through managing blood glucose levels. The present study elucidates the anti-hyperglycemic mechanism of water-soluble LMWC (∼20 kDa), the ch...
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Elsevier
2024-12-01
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| Series: | Carbohydrate Polymer Technologies and Applications |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666893924001142 |
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| author | Priyanka D․ N․ Harish Prashanth K․ V․ |
| author_facet | Priyanka D․ N․ Harish Prashanth K․ V․ |
| author_sort | Priyanka D․ N․ |
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| description | Diabetes, a metabolic syndrome, is a leading global cause of morbidity and mortality. Dietary polysaccharide intervention besides medication, helps in diabetes through managing blood glucose levels. The present study elucidates the anti-hyperglycemic mechanism of water-soluble LMWC (∼20 kDa), the chitosan derivative, in type-1 diabetic (T1DM) male Wistar rats induced by streptozotocin (STZ, 36 mg/kg b.w.). LMWC1 (100 mg/kg b.w.) and LMWC2 (250 mg/kg b.w.) were administered orally on alternative days for 4 weeks. LMWC lowered fasting blood glucose levels and improved symptoms like polyphagia, polydipsia, polyuria, and serum insulin levels in a dose-dependent manner. It also ameliorated hyperglycemia & dyslipidemia by mitigating the levels of pro-inflammatory factors and oxidative stress levels in the pancreas and liver. Additionally, LMWC increased the activity of key proteins involved in insulin signaling in these organs through the AKT/PI3K/FOXO pathway, enhancing insulin secretion and improving glucose metabolism in T1DM rats. This contributed to improved hepatic glycogen synthesis and suppression of gluconeogenesis in T1DM rats. In summary, LMWC could be an effective antidiabetic supplement, offering insights into dietary treatment for diabetes management. |
| format | Article |
| id | doaj-art-48ca49b83f284e298c60ffeeaf08bed2 |
| institution | Kabale University |
| issn | 2666-8939 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Carbohydrate Polymer Technologies and Applications |
| spelling | doaj-art-48ca49b83f284e298c60ffeeaf08bed22024-12-13T11:06:17ZengElsevierCarbohydrate Polymer Technologies and Applications2666-89392024-12-018100534Low molecular weight chitosan (∼20 kDa) exhibits in vivo anti-hyperglycemic effects through AKT/PI3K/FOXO pathwayPriyanka D․ N․0Harish Prashanth K․ V․1Functional Biopolymer Lab, Department of Biochemistry, CSIR-Central Food Technological Research Institute, Mysuru 570020, Karnataka, IndiaCorresponding author.; Functional Biopolymer Lab, Department of Biochemistry, CSIR-Central Food Technological Research Institute, Mysuru 570020, Karnataka, IndiaDiabetes, a metabolic syndrome, is a leading global cause of morbidity and mortality. Dietary polysaccharide intervention besides medication, helps in diabetes through managing blood glucose levels. The present study elucidates the anti-hyperglycemic mechanism of water-soluble LMWC (∼20 kDa), the chitosan derivative, in type-1 diabetic (T1DM) male Wistar rats induced by streptozotocin (STZ, 36 mg/kg b.w.). LMWC1 (100 mg/kg b.w.) and LMWC2 (250 mg/kg b.w.) were administered orally on alternative days for 4 weeks. LMWC lowered fasting blood glucose levels and improved symptoms like polyphagia, polydipsia, polyuria, and serum insulin levels in a dose-dependent manner. It also ameliorated hyperglycemia & dyslipidemia by mitigating the levels of pro-inflammatory factors and oxidative stress levels in the pancreas and liver. Additionally, LMWC increased the activity of key proteins involved in insulin signaling in these organs through the AKT/PI3K/FOXO pathway, enhancing insulin secretion and improving glucose metabolism in T1DM rats. This contributed to improved hepatic glycogen synthesis and suppression of gluconeogenesis in T1DM rats. In summary, LMWC could be an effective antidiabetic supplement, offering insights into dietary treatment for diabetes management.http://www.sciencedirect.com/science/article/pii/S2666893924001142Low molecular weight chitosanWater solubleHyperglycemiaAntidiabetic supplementDyslipidemiaT1DM |
| spellingShingle | Priyanka D․ N․ Harish Prashanth K․ V․ Low molecular weight chitosan (∼20 kDa) exhibits in vivo anti-hyperglycemic effects through AKT/PI3K/FOXO pathway Carbohydrate Polymer Technologies and Applications Low molecular weight chitosan Water soluble Hyperglycemia Antidiabetic supplement Dyslipidemia T1DM |
| title | Low molecular weight chitosan (∼20 kDa) exhibits in vivo anti-hyperglycemic effects through AKT/PI3K/FOXO pathway |
| title_full | Low molecular weight chitosan (∼20 kDa) exhibits in vivo anti-hyperglycemic effects through AKT/PI3K/FOXO pathway |
| title_fullStr | Low molecular weight chitosan (∼20 kDa) exhibits in vivo anti-hyperglycemic effects through AKT/PI3K/FOXO pathway |
| title_full_unstemmed | Low molecular weight chitosan (∼20 kDa) exhibits in vivo anti-hyperglycemic effects through AKT/PI3K/FOXO pathway |
| title_short | Low molecular weight chitosan (∼20 kDa) exhibits in vivo anti-hyperglycemic effects through AKT/PI3K/FOXO pathway |
| title_sort | low molecular weight chitosan ∼20 kda exhibits in vivo anti hyperglycemic effects through akt pi3k foxo pathway |
| topic | Low molecular weight chitosan Water soluble Hyperglycemia Antidiabetic supplement Dyslipidemia T1DM |
| url | http://www.sciencedirect.com/science/article/pii/S2666893924001142 |
| work_keys_str_mv | AT priyankadn lowmolecularweightchitosan20kdaexhibitsinvivoantihyperglycemiceffectsthroughaktpi3kfoxopathway AT harishprashanthkv lowmolecularweightchitosan20kdaexhibitsinvivoantihyperglycemiceffectsthroughaktpi3kfoxopathway |