Survey of willingness to participate in clinical trials and influencing factors among cancer and non-cancer patients
Abstract Despite the expanding landscape of clinical trials, there is a lack of study concerning Malaysian patients’ participation and perspectives. This study addresses these gaps by assessing patients’ willingness, knowledge, perceptions, confidence, and religious barriers related to clinical tria...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-83626-7 |
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| author | Teck Long King Shirin Hui Tan Shirley Siang Ning Tan Wei Hong Lai Mohamad Adam Bujang Pei Jye Voon |
| author_facet | Teck Long King Shirin Hui Tan Shirley Siang Ning Tan Wei Hong Lai Mohamad Adam Bujang Pei Jye Voon |
| author_sort | Teck Long King |
| collection | DOAJ |
| description | Abstract Despite the expanding landscape of clinical trials, there is a lack of study concerning Malaysian patients’ participation and perspectives. This study addresses these gaps by assessing patients’ willingness, knowledge, perceptions, confidence, and religious barriers related to clinical trial participations at Sarawak General Hospital. We conducted a cross-sectional survey from March to September 2022 on 763 cancer and non-cancer patients. We collected patients’ responses and calculated scores for willingness to participate (40.5/100), knowledge (29.9/100), perceived benefits (66.5/100) and risks (72.4/100) of participations, confidence in clinical trial conducts (66.3/100), and religious barriers (49.8/100). The higher scores indicated greater willingness, better knowledge, stronger perceptions of benefits and risk, increased confidence, and stronger religious barriers. Cancer patient demonstrated significantly greater willingness for trials involving new drugs (31.9/100 vs. 27.4/100, p = 0.021) but slightly higher religious barriers compared to non-cancer cohort (51.4/100 vs. 48.3/100, p = 0.006). Multivariable logistic regression identified female gender, unemployment, poor knowledge, low perceived benefits, high perceived risks, and low confidence as significant factors associated with reduced willingness to participate (p < 0.05). This study underscores the challenges in engaging Malaysian patients in clinical trials, particularly in Sarawak, emphasising the need for targeted strategies to raise awareness, effective communication, and enhancing public confidence in clinical trials. |
| format | Article |
| id | doaj-art-48944ecf2aa4452eb146fe9755e25e43 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-48944ecf2aa4452eb146fe9755e25e432025-01-12T12:21:37ZengNature PortfolioScientific Reports2045-23222025-01-011511910.1038/s41598-024-83626-7Survey of willingness to participate in clinical trials and influencing factors among cancer and non-cancer patientsTeck Long King0Shirin Hui Tan1Shirley Siang Ning Tan2Wei Hong Lai3Mohamad Adam Bujang4Pei Jye Voon5Clinical Research Centre Sarawak General Hospital, Institute for Clinical Research, National Institutes of Health, Ministry of HealthClinical Research Centre Sarawak General Hospital, Institute for Clinical Research, National Institutes of Health, Ministry of HealthClinical Research Centre Sarawak General Hospital, Institute for Clinical Research, National Institutes of Health, Ministry of HealthClinical Research Centre Sarawak General Hospital, Institute for Clinical Research, National Institutes of Health, Ministry of HealthClinical Research Centre Sarawak General Hospital, Institute for Clinical Research, National Institutes of Health, Ministry of HealthDepartment of Radiotherapy, Oncology, and Palliative Care, Sarawak General Hospital, Ministry of HealthAbstract Despite the expanding landscape of clinical trials, there is a lack of study concerning Malaysian patients’ participation and perspectives. This study addresses these gaps by assessing patients’ willingness, knowledge, perceptions, confidence, and religious barriers related to clinical trial participations at Sarawak General Hospital. We conducted a cross-sectional survey from March to September 2022 on 763 cancer and non-cancer patients. We collected patients’ responses and calculated scores for willingness to participate (40.5/100), knowledge (29.9/100), perceived benefits (66.5/100) and risks (72.4/100) of participations, confidence in clinical trial conducts (66.3/100), and religious barriers (49.8/100). The higher scores indicated greater willingness, better knowledge, stronger perceptions of benefits and risk, increased confidence, and stronger religious barriers. Cancer patient demonstrated significantly greater willingness for trials involving new drugs (31.9/100 vs. 27.4/100, p = 0.021) but slightly higher religious barriers compared to non-cancer cohort (51.4/100 vs. 48.3/100, p = 0.006). Multivariable logistic regression identified female gender, unemployment, poor knowledge, low perceived benefits, high perceived risks, and low confidence as significant factors associated with reduced willingness to participate (p < 0.05). This study underscores the challenges in engaging Malaysian patients in clinical trials, particularly in Sarawak, emphasising the need for targeted strategies to raise awareness, effective communication, and enhancing public confidence in clinical trials.https://doi.org/10.1038/s41598-024-83626-7 |
| spellingShingle | Teck Long King Shirin Hui Tan Shirley Siang Ning Tan Wei Hong Lai Mohamad Adam Bujang Pei Jye Voon Survey of willingness to participate in clinical trials and influencing factors among cancer and non-cancer patients Scientific Reports |
| title | Survey of willingness to participate in clinical trials and influencing factors among cancer and non-cancer patients |
| title_full | Survey of willingness to participate in clinical trials and influencing factors among cancer and non-cancer patients |
| title_fullStr | Survey of willingness to participate in clinical trials and influencing factors among cancer and non-cancer patients |
| title_full_unstemmed | Survey of willingness to participate in clinical trials and influencing factors among cancer and non-cancer patients |
| title_short | Survey of willingness to participate in clinical trials and influencing factors among cancer and non-cancer patients |
| title_sort | survey of willingness to participate in clinical trials and influencing factors among cancer and non cancer patients |
| url | https://doi.org/10.1038/s41598-024-83626-7 |
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