Cough in non-cystic fibrosis bronchiectasis
Non-cystic fibrosis bronchiectasis (NCFBE) belongs to the spectrum of chronic suppurative lung diseases and is characterised by persistent wet/sputum-productive cough and airway dilatation. Morphological and structural changes in the airways lead to changes in airflow, impair breathing-induced mucus...
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| Format: | Article |
| Language: | English |
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European Respiratory Society
2024-12-01
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| Series: | ERJ Open Research |
| Online Access: | http://openres.ersjournals.com/content/10/6/00330-2024.full |
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| author | Ahmad Kantar Woo-Jung Song Andrew Bush Grigorios Chatziparasidis |
| author_facet | Ahmad Kantar Woo-Jung Song Andrew Bush Grigorios Chatziparasidis |
| author_sort | Ahmad Kantar |
| collection | DOAJ |
| description | Non-cystic fibrosis bronchiectasis (NCFBE) belongs to the spectrum of chronic suppurative lung diseases and is characterised by persistent wet/sputum-productive cough and airway dilatation. Morphological and structural changes in the airways lead to changes in airflow, impair breathing-induced mucus transport and sliding, and reduce the shear forces of cough. Moreover, mucus hyperviscosity contributes to compromised ciliary activity and the pathogenesis of the disease. This mini-review highlights the role of cough in NCFBE, especially with respect to mucus clearance. Cough is the principal backup mechanism when mucus clearance is impaired due to either reduced function of cilia- and breathing-induced mucus transport, or abnormal mucus, or both. The efficiency of cough in overcoming the cohesive and adhesive properties of mucus is determined by both the forces applied to mucus by airflow and the mucus–airway surface properties. In NCFBE, mucus hyperviscosity contributes to impaired mucus clearance and determines disease pathogenesis; therefore, it may be a therapeutic target. The primary objectives of physiotherapy regimens in NCFBE are mucus hydration and the establishment of an optimal expiratory airflow velocity, which exerts shearing forces on the mucus located on the airway surface. Modifying the rheological properties of mucus and enhancing its transport whenever possible (by breathing manoeuvres, ciliary activity and cough) represent prime goals in preventing disease progression and, indeed reversing, bronchiectasis in the early stages of the disease, as well as preventing pulmonary exacerbations. |
| format | Article |
| id | doaj-art-48817872372b41e997beea81d1b9193f |
| institution | Kabale University |
| issn | 2312-0541 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | ERJ Open Research |
| spelling | doaj-art-48817872372b41e997beea81d1b9193f2025-01-14T09:50:21ZengEuropean Respiratory SocietyERJ Open Research2312-05412024-12-0110610.1183/23120541.00330-202400330-2024Cough in non-cystic fibrosis bronchiectasisAhmad Kantar0Woo-Jung Song1Andrew Bush2Grigorios Chatziparasidis3 Paediatric Asthma and Cough Centre, Instituti Ospedalieri Bergamaschi, Bergamo, Italy Department of Allergy and Clinical Immunology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea Department of Paediatric Respiratory Medicine, Royal Brompton Hospital and National Heart and Lung Institute, School of Medicine, Imperial College London, London, UK Faculty of Nursing, University of Thessaly, Volos, Greece Non-cystic fibrosis bronchiectasis (NCFBE) belongs to the spectrum of chronic suppurative lung diseases and is characterised by persistent wet/sputum-productive cough and airway dilatation. Morphological and structural changes in the airways lead to changes in airflow, impair breathing-induced mucus transport and sliding, and reduce the shear forces of cough. Moreover, mucus hyperviscosity contributes to compromised ciliary activity and the pathogenesis of the disease. This mini-review highlights the role of cough in NCFBE, especially with respect to mucus clearance. Cough is the principal backup mechanism when mucus clearance is impaired due to either reduced function of cilia- and breathing-induced mucus transport, or abnormal mucus, or both. The efficiency of cough in overcoming the cohesive and adhesive properties of mucus is determined by both the forces applied to mucus by airflow and the mucus–airway surface properties. In NCFBE, mucus hyperviscosity contributes to impaired mucus clearance and determines disease pathogenesis; therefore, it may be a therapeutic target. The primary objectives of physiotherapy regimens in NCFBE are mucus hydration and the establishment of an optimal expiratory airflow velocity, which exerts shearing forces on the mucus located on the airway surface. Modifying the rheological properties of mucus and enhancing its transport whenever possible (by breathing manoeuvres, ciliary activity and cough) represent prime goals in preventing disease progression and, indeed reversing, bronchiectasis in the early stages of the disease, as well as preventing pulmonary exacerbations.http://openres.ersjournals.com/content/10/6/00330-2024.full |
| spellingShingle | Ahmad Kantar Woo-Jung Song Andrew Bush Grigorios Chatziparasidis Cough in non-cystic fibrosis bronchiectasis ERJ Open Research |
| title | Cough in non-cystic fibrosis bronchiectasis |
| title_full | Cough in non-cystic fibrosis bronchiectasis |
| title_fullStr | Cough in non-cystic fibrosis bronchiectasis |
| title_full_unstemmed | Cough in non-cystic fibrosis bronchiectasis |
| title_short | Cough in non-cystic fibrosis bronchiectasis |
| title_sort | cough in non cystic fibrosis bronchiectasis |
| url | http://openres.ersjournals.com/content/10/6/00330-2024.full |
| work_keys_str_mv | AT ahmadkantar coughinnoncysticfibrosisbronchiectasis AT woojungsong coughinnoncysticfibrosisbronchiectasis AT andrewbush coughinnoncysticfibrosisbronchiectasis AT grigorioschatziparasidis coughinnoncysticfibrosisbronchiectasis |