Differential TLR-ERK1/2 Activity Promotes Viral ssRNA and dsRNA Mimic-Induced Dysregulated Immunity in Macrophages

Differential TLR-ERK1/2 Activity Promotes Viral ssRNA and dsRNA Mimic-Induced Dysregulated Immunity in Macrophages

RNA virus-induced excessive inflammation and impaired antiviral interferon (IFN-I) responses are associated with severe disease. This innate immune response, also referred to as “dysregulated immunity” is caused by viral single-stranded RNA (ssRNA)- and double-stranded-RNA (dsRNA)-mediated exuberant...

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Bibliographic Details
Main Authors: Rakshya Shrestha, Paige Marie Johnson, Roshan Ghimire, Cody John Whitley, Rudragouda Channappanavar
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Pathogens
Subjects:
SARS-CoV-2
TLRs
ERK1/2
interferon
inflammation
macrophages
Online Access:https://www.mdpi.com/2076-0817/13/12/1033
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