New Triterpenoids from the Leaves of <i>Heritiera littoralis</i> and Their Anti-Inflammatory Activity
Six new triterpenoids, heritieras C–H (<b>1</b>–<b>6</b>), along with thirteen known triterpenoids (<b>7</b>–<b>19</b>), were isolated from the leaves of <i>Heritiera littoralis</i>. Their structures were identified by spectroscopic analysi...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/30/1/131 |
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| Summary: | Six new triterpenoids, heritieras C–H (<b>1</b>–<b>6</b>), along with thirteen known triterpenoids (<b>7</b>–<b>19</b>), were isolated from the leaves of <i>Heritiera littoralis</i>. Their structures were identified by spectroscopic analysis, including 1D and 2D nuclear magnetic resonance (NMR), high-resolution electrospray ionization mass spectrometry (HRESIMS), and by comparison with the literature. Anti-inflammatory activity of the isolates was evaluated using the lipopolysaccharide (LPS) stimulated RAW 264.7 cell model. Among the isolated triterpenoid, compounds <b>1</b>, <b>12</b>, <b>16</b>, <b>17</b>, and <b>18</b> demonstrated inhibitory activity against nitric oxide (NO) release, in which compound <b>18</b> exhibited the best activity with an IC<sub>50</sub> value of 18.13 μM. The potential anti-inflammatory mechanism was investigated using molecular docking. The triterpenoids from <i>H. littoralis</i> could be served as potential candidates for the development of new anti-inflammatory agents. |
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| ISSN: | 1420-3049 |