Changes in sarcopenia and incident cardiovascular disease in prospective cohorts
Abstract Background Previous studies have identified sarcopenia as a significant risk factor for cardiovascular disease (CVD). However, these studies primarily focused on sarcopenia status at baseline, without considering changes in sarcopenia status during follow-up. The aim of this study is to inv...
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BMC
2024-12-01
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| Online Access: | https://doi.org/10.1186/s12916-024-03841-x |
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| author | Qingyue Zeng Lijun Zhao Qian Zhong Zhenmei An Shuangqing Li |
| author_facet | Qingyue Zeng Lijun Zhao Qian Zhong Zhenmei An Shuangqing Li |
| author_sort | Qingyue Zeng |
| collection | DOAJ |
| description | Abstract Background Previous studies have identified sarcopenia as a significant risk factor for cardiovascular disease (CVD). However, these studies primarily focused on sarcopenia status at baseline, without considering changes in sarcopenia status during follow-up. The aim of this study is to investigate the association between changes in sarcopenia status and the incidence of new-onset cardiovascular disease. Methods This study utilized prospective cohort data from the China Health and Retirement Longitudinal Study (CHARLS). Sarcopenia status was assessed using the 2019 Asian Working Group for Sarcopenia (AWGS) algorithm and categorized as non-sarcopenia, possible sarcopenia, or sarcopenia. Changes in sarcopenia status were evaluated based on assessments at baseline and at the second follow-up survey 2 years later. CVD was identified through self-reported physician diagnoses of heart disease, including angina, myocardial infarction, congestive heart failure, and other heart problems, or stroke. Cox proportional hazards models were employed to calculate hazard ratios (HRs) and 95% confidence intervals (CIs), adjusting for potential confounding factors. Results Based on the inclusion and exclusion criteria, a total of 7499 CHARLS participants were included in the analysis, with 50.8% being female and an average age of 58.5 years. Compared to participants with stable non-sarcopenia status, those who progressed from non-sarcopenia to possible sarcopenia or sarcopenia exhibited a significantly increased risk of new-onset CVD (HR 1.30, 95% CI 1.06–1.59). Conversely, participants who recovered from sarcopenia to non-sarcopenia or possible sarcopenia had a significantly reduced risk of new-onset CVD compared to those with stable sarcopenia status (HR 0.61, 95% CI 0.37–0.99). Among participants with baseline possible sarcopenia, those who recovered to non-sarcopenia had a significantly lower risk of new-onset CVD compared to those with stable possible sarcopenia status (HR 0.67, 95% CI 0.52–0.86). Conclusions Changes in sarcopenia status are associated with varying risks of new-onset CVD. Progression in sarcopenia status increases the risk, while recovery from sarcopenia reduces the risk of developing cardiovascular disease. Graphical Abstract |
| format | Article |
| id | doaj-art-4802481d15c542639098fc92666bc775 |
| institution | Kabale University |
| issn | 1741-7015 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medicine |
| spelling | doaj-art-4802481d15c542639098fc92666bc7752025-01-05T12:32:50ZengBMCBMC Medicine1741-70152024-12-0122111110.1186/s12916-024-03841-xChanges in sarcopenia and incident cardiovascular disease in prospective cohortsQingyue Zeng0Lijun Zhao1Qian Zhong2Zhenmei An3Shuangqing Li4General Practice Ward/International Medical Center Ward, General Practice Medical Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan UniversityGeneral Practice Ward/International Medical Center Ward, General Practice Medical Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan UniversityDepartment of Endocrinology and Metabolism, West China Hospital, Sichuan UniversityDepartment of Endocrinology and Metabolism, West China Hospital, Sichuan UniversityGeneral Practice Ward/International Medical Center Ward, General Practice Medical Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan UniversityAbstract Background Previous studies have identified sarcopenia as a significant risk factor for cardiovascular disease (CVD). However, these studies primarily focused on sarcopenia status at baseline, without considering changes in sarcopenia status during follow-up. The aim of this study is to investigate the association between changes in sarcopenia status and the incidence of new-onset cardiovascular disease. Methods This study utilized prospective cohort data from the China Health and Retirement Longitudinal Study (CHARLS). Sarcopenia status was assessed using the 2019 Asian Working Group for Sarcopenia (AWGS) algorithm and categorized as non-sarcopenia, possible sarcopenia, or sarcopenia. Changes in sarcopenia status were evaluated based on assessments at baseline and at the second follow-up survey 2 years later. CVD was identified through self-reported physician diagnoses of heart disease, including angina, myocardial infarction, congestive heart failure, and other heart problems, or stroke. Cox proportional hazards models were employed to calculate hazard ratios (HRs) and 95% confidence intervals (CIs), adjusting for potential confounding factors. Results Based on the inclusion and exclusion criteria, a total of 7499 CHARLS participants were included in the analysis, with 50.8% being female and an average age of 58.5 years. Compared to participants with stable non-sarcopenia status, those who progressed from non-sarcopenia to possible sarcopenia or sarcopenia exhibited a significantly increased risk of new-onset CVD (HR 1.30, 95% CI 1.06–1.59). Conversely, participants who recovered from sarcopenia to non-sarcopenia or possible sarcopenia had a significantly reduced risk of new-onset CVD compared to those with stable sarcopenia status (HR 0.61, 95% CI 0.37–0.99). Among participants with baseline possible sarcopenia, those who recovered to non-sarcopenia had a significantly lower risk of new-onset CVD compared to those with stable possible sarcopenia status (HR 0.67, 95% CI 0.52–0.86). Conclusions Changes in sarcopenia status are associated with varying risks of new-onset CVD. Progression in sarcopenia status increases the risk, while recovery from sarcopenia reduces the risk of developing cardiovascular disease. Graphical Abstracthttps://doi.org/10.1186/s12916-024-03841-xSarcopeniaCardiovascular diseaseDynamic natureEpidemiology |
| spellingShingle | Qingyue Zeng Lijun Zhao Qian Zhong Zhenmei An Shuangqing Li Changes in sarcopenia and incident cardiovascular disease in prospective cohorts BMC Medicine Sarcopenia Cardiovascular disease Dynamic nature Epidemiology |
| title | Changes in sarcopenia and incident cardiovascular disease in prospective cohorts |
| title_full | Changes in sarcopenia and incident cardiovascular disease in prospective cohorts |
| title_fullStr | Changes in sarcopenia and incident cardiovascular disease in prospective cohorts |
| title_full_unstemmed | Changes in sarcopenia and incident cardiovascular disease in prospective cohorts |
| title_short | Changes in sarcopenia and incident cardiovascular disease in prospective cohorts |
| title_sort | changes in sarcopenia and incident cardiovascular disease in prospective cohorts |
| topic | Sarcopenia Cardiovascular disease Dynamic nature Epidemiology |
| url | https://doi.org/10.1186/s12916-024-03841-x |
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