Prolonging effect of polyvinyl alcohol on the drug release
Polymers are currently of interest as drug delivery systems. The use of polymeric forms of medicinal substances will eliminate or reduce the disadvantages of traditional drugs. The purpose of this work was to assess the ability to prolong the action of polyvinyl alcohol in relation to the drug relea...
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| Format: | Article |
| Language: | English |
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Uralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. Elʹcina
2022-05-01
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| Series: | Chimica Techno Acta |
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| Online Access: | https://chimicatechnoacta.ru/article/view/5853 |
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| _version_ | 1846109559516561408 |
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| author | Anzhela Shurshina Roman Lazdin Elena Zakharova Anastasiya Titlova Elena Kulish |
| author_facet | Anzhela Shurshina Roman Lazdin Elena Zakharova Anastasiya Titlova Elena Kulish |
| author_sort | Anzhela Shurshina |
| collection | DOAJ |
| description | Polymers are currently of interest as drug delivery systems. The use of polymeric forms of medicinal substances will eliminate or reduce the disadvantages of traditional drugs. The purpose of this work was to assess the ability to prolong the action of polyvinyl alcohol in relation to the drug release when going from dilute to more concentrated solutions. It was established that an increase in the viscosity of the polymer in solution caused by an increase in its concentration results not only in a slowdown in the diffusion of drugs from the polymer solution, but also in a significant decrease in the amount of drugs firmly fixed on the polymer matrix. Since it is the adduct of the polyvinyl alcohol-drug interaction that provides the slow release of the drug from the polymer solution, a decrease in its amount leads to the fact that no enhancement of the prolonging action is observed. It is claimed that when moving from solutions to polymer films, the rate of drug release is also determined by the structure of the polymer matrix. The lower the density of the polymer film, the greater the diffusion coefficient of the drug release from the film. Thus, in the course of evaluating the ability to prolong the action of polyvinyl alcohol, it was shown that using some prolongation techniques, it is possible to achieve targeted regulation of the rate of drug release from polymer dosage forms. |
| format | Article |
| id | doaj-art-47f4c1e3fb0f4c4085da7db748c5da40 |
| institution | Kabale University |
| issn | 2411-1414 |
| language | English |
| publishDate | 2022-05-01 |
| publisher | Uralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. Elʹcina |
| record_format | Article |
| series | Chimica Techno Acta |
| spelling | doaj-art-47f4c1e3fb0f4c4085da7db748c5da402024-12-25T09:36:54ZengUralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. ElʹcinaChimica Techno Acta2411-14142022-05-019210.15826/chimtech.2022.9.2.064419Prolonging effect of polyvinyl alcohol on the drug releaseAnzhela Shurshina0Roman Lazdin1Elena Zakharova2Anastasiya Titlova3Elena Kulish4Bashkir State UniversityBashkir State UniversityBashkir State UniversityBashkir State UniversityBashkir State UniversityPolymers are currently of interest as drug delivery systems. The use of polymeric forms of medicinal substances will eliminate or reduce the disadvantages of traditional drugs. The purpose of this work was to assess the ability to prolong the action of polyvinyl alcohol in relation to the drug release when going from dilute to more concentrated solutions. It was established that an increase in the viscosity of the polymer in solution caused by an increase in its concentration results not only in a slowdown in the diffusion of drugs from the polymer solution, but also in a significant decrease in the amount of drugs firmly fixed on the polymer matrix. Since it is the adduct of the polyvinyl alcohol-drug interaction that provides the slow release of the drug from the polymer solution, a decrease in its amount leads to the fact that no enhancement of the prolonging action is observed. It is claimed that when moving from solutions to polymer films, the rate of drug release is also determined by the structure of the polymer matrix. The lower the density of the polymer film, the greater the diffusion coefficient of the drug release from the film. Thus, in the course of evaluating the ability to prolong the action of polyvinyl alcohol, it was shown that using some prolongation techniques, it is possible to achieve targeted regulation of the rate of drug release from polymer dosage forms.https://chimicatechnoacta.ru/article/view/5853polyvinyl alcoholprolongationdrug deliverypolymer film |
| spellingShingle | Anzhela Shurshina Roman Lazdin Elena Zakharova Anastasiya Titlova Elena Kulish Prolonging effect of polyvinyl alcohol on the drug release Chimica Techno Acta polyvinyl alcohol prolongation drug delivery polymer film |
| title | Prolonging effect of polyvinyl alcohol on the drug release |
| title_full | Prolonging effect of polyvinyl alcohol on the drug release |
| title_fullStr | Prolonging effect of polyvinyl alcohol on the drug release |
| title_full_unstemmed | Prolonging effect of polyvinyl alcohol on the drug release |
| title_short | Prolonging effect of polyvinyl alcohol on the drug release |
| title_sort | prolonging effect of polyvinyl alcohol on the drug release |
| topic | polyvinyl alcohol prolongation drug delivery polymer film |
| url | https://chimicatechnoacta.ru/article/view/5853 |
| work_keys_str_mv | AT anzhelashurshina prolongingeffectofpolyvinylalcoholonthedrugrelease AT romanlazdin prolongingeffectofpolyvinylalcoholonthedrugrelease AT elenazakharova prolongingeffectofpolyvinylalcoholonthedrugrelease AT anastasiyatitlova prolongingeffectofpolyvinylalcoholonthedrugrelease AT elenakulish prolongingeffectofpolyvinylalcoholonthedrugrelease |