Advancing outcome measure development and analytical approaches: Pain in Animals Workshop 2023
Annually, millions of humans and animals suffer from chronic and acute pain, creating welfare and quality of life concerns for both humans and animals who suffer this pain. In developing new therapeutic approaches, the challenge is to accurately measure this pain to ascertain the efficacy of novel t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Pain Research |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpain.2025.1615862/full |
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| author | B. D. X. Lascelles B. D. X. Lascelles B. D. X. Lascelles D. Barratt P. S. Basran D. C. Brown J. F. Coetzee M. Gill M. R. Hutchinson C. Johnson S. P. L. Luna D. P. Mohapatra M. L. Oshinsky S. Robertson C. F. Ruberman E. R. Smith Q. Zhang |
| author_facet | B. D. X. Lascelles B. D. X. Lascelles B. D. X. Lascelles D. Barratt P. S. Basran D. C. Brown J. F. Coetzee M. Gill M. R. Hutchinson C. Johnson S. P. L. Luna D. P. Mohapatra M. L. Oshinsky S. Robertson C. F. Ruberman E. R. Smith Q. Zhang |
| author_sort | B. D. X. Lascelles |
| collection | DOAJ |
| description | Annually, millions of humans and animals suffer from chronic and acute pain, creating welfare and quality of life concerns for both humans and animals who suffer this pain. In developing new therapeutic approaches, the challenge is to accurately measure this pain to ascertain the efficacy of novel therapeutics. Additionally, there is a need to develop new and effective analgesic options that may offer alternatives to using opioids that contribute to the opioid epidemic. The Pain in Animals Workshop (PAW) meetings are held every other year in partnership with the National Institutes of Health (NIH), bringing key stakeholders together to understand pain in humans and animals better. The 2023 workshop focused on presenting and discussing updates on validated approaches to measuring pain, highlighting opportunity areas for additional outcome measure development. It also discussed study design and analytic approaches to the use of outcome measures in clinical trials, including the important concepts of success-failure approaches and the application of multiple endpoints in evaluating analgesic therapies. The workshop also introduced the concept of the biopsychosocial model of pain, broadening the conversation around the impact of pain and thus opportunities to modulate the pain experience. The application of artificial intelligence to the measurement of pain was introduced. The workshop brought together academia, government, and industry experts in human and animal pain assessment and analgesic intervention development. Given the topic's importance and the meeting's uniqueness, capturing the thoughts and ideas presented and discussed is critical. This narrative is one product from that meeting, summarizing several presentations from the workshop. |
| format | Article |
| id | doaj-art-47dcface7ba44f5691d9ae428612b791 |
| institution | Kabale University |
| issn | 2673-561X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pain Research |
| spelling | doaj-art-47dcface7ba44f5691d9ae428612b7912025-08-21T05:27:14ZengFrontiers Media S.A.Frontiers in Pain Research2673-561X2025-08-01610.3389/fpain.2025.16158621615862Advancing outcome measure development and analytical approaches: Pain in Animals Workshop 2023B. D. X. Lascelles0B. D. X. Lascelles1B. D. X. Lascelles2D. Barratt3P. S. Basran4D. C. Brown5J. F. Coetzee6M. Gill7M. R. Hutchinson8C. Johnson9S. P. L. Luna10D. P. Mohapatra11M. L. Oshinsky12S. Robertson13C. F. Ruberman14E. R. Smith15Q. Zhang16Translational Research in Pain and Comparative Pain Research and Education Center, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, United StatesThurston Arthritis Center, UNC School of Medicine, Chapel Hill, NC, United StatesCenter for Translational Pain Research, Department of Anesthesiology, Duke University, Durham, NC, United StatesSchool of Biomedicine, University of Adelaide, Adelaide, SA, AustraliaCollege of Veterinary Medicine, Cornell University, Ithaca, NY, United StatesMedical Affairs, Mars Veterinary Health, Vancouver, WA, United StatesDepartment of Anatomy and Physiology, Kansas State University, Manhattan, KS, United StatesNational Institute of Neurological Disorders and Stroke/National Institutes of Health, Bethesda, MD, United StatesSchool of Biomedicine, University of Adelaide, Adelaide, SA, AustraliaCenter for Veterinary Medicine, Food and Drug Administration, Rockville, MD, United States0Faculty of Veterinary Medicine and Animal Science, Sao Paulo State University, Botucatu, BrazilNational Institute of Neurological Disorders and Stroke/National Institutes of Health, Bethesda, MD, United StatesNational Institute of Neurological Disorders and Stroke/National Institutes of Health, Bethesda, MD, United States1Lap of Love Veterinary Hospice, Lutz, FL, United StatesCenter for Veterinary Medicine, Food and Drug Administration, Rockville, MD, United StatesCenter for Veterinary Medicine, Food and Drug Administration, Rockville, MD, United StatesCenter for Veterinary Medicine, Food and Drug Administration, Rockville, MD, United StatesAnnually, millions of humans and animals suffer from chronic and acute pain, creating welfare and quality of life concerns for both humans and animals who suffer this pain. In developing new therapeutic approaches, the challenge is to accurately measure this pain to ascertain the efficacy of novel therapeutics. Additionally, there is a need to develop new and effective analgesic options that may offer alternatives to using opioids that contribute to the opioid epidemic. The Pain in Animals Workshop (PAW) meetings are held every other year in partnership with the National Institutes of Health (NIH), bringing key stakeholders together to understand pain in humans and animals better. The 2023 workshop focused on presenting and discussing updates on validated approaches to measuring pain, highlighting opportunity areas for additional outcome measure development. It also discussed study design and analytic approaches to the use of outcome measures in clinical trials, including the important concepts of success-failure approaches and the application of multiple endpoints in evaluating analgesic therapies. The workshop also introduced the concept of the biopsychosocial model of pain, broadening the conversation around the impact of pain and thus opportunities to modulate the pain experience. The application of artificial intelligence to the measurement of pain was introduced. The workshop brought together academia, government, and industry experts in human and animal pain assessment and analgesic intervention development. Given the topic's importance and the meeting's uniqueness, capturing the thoughts and ideas presented and discussed is critical. This narrative is one product from that meeting, summarizing several presentations from the workshop.https://www.frontiersin.org/articles/10.3389/fpain.2025.1615862/fullpainPain in Animals Workshoptranslationalmeasurementbiomarker |
| spellingShingle | B. D. X. Lascelles B. D. X. Lascelles B. D. X. Lascelles D. Barratt P. S. Basran D. C. Brown J. F. Coetzee M. Gill M. R. Hutchinson C. Johnson S. P. L. Luna D. P. Mohapatra M. L. Oshinsky S. Robertson C. F. Ruberman E. R. Smith Q. Zhang Advancing outcome measure development and analytical approaches: Pain in Animals Workshop 2023 Frontiers in Pain Research pain Pain in Animals Workshop translational measurement biomarker |
| title | Advancing outcome measure development and analytical approaches: Pain in Animals Workshop 2023 |
| title_full | Advancing outcome measure development and analytical approaches: Pain in Animals Workshop 2023 |
| title_fullStr | Advancing outcome measure development and analytical approaches: Pain in Animals Workshop 2023 |
| title_full_unstemmed | Advancing outcome measure development and analytical approaches: Pain in Animals Workshop 2023 |
| title_short | Advancing outcome measure development and analytical approaches: Pain in Animals Workshop 2023 |
| title_sort | advancing outcome measure development and analytical approaches pain in animals workshop 2023 |
| topic | pain Pain in Animals Workshop translational measurement biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fpain.2025.1615862/full |
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