Precision medicine and patient outcomes in intensive care unit: Culture sensitivity, antibiotics, and APACHE score IV
BACKGROUND: In the intensive care unit (ICU), complex medical conditions require specialized care; the threat of antibiotic resistance is significant due to frequent antibiotic use. This study investigates the pivotal role of culture sensitivity testing in shaping antibiotic prescription practices a...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-11-01
|
| Series: | Journal of Education and Health Promotion |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jehp.jehp_1833_23 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846134485170520064 |
|---|---|
| author | Sidra Zubair Subia Jamil Sakina Fatima Syed T. Sibtain Hira Raees Asma Eraj Amber Nawab |
| author_facet | Sidra Zubair Subia Jamil Sakina Fatima Syed T. Sibtain Hira Raees Asma Eraj Amber Nawab |
| author_sort | Sidra Zubair |
| collection | DOAJ |
| description | BACKGROUND:
In the intensive care unit (ICU), complex medical conditions require specialized care; the threat of antibiotic resistance is significant due to frequent antibiotic use. This study investigates the pivotal role of culture sensitivity testing in shaping antibiotic prescription practices and patient outcomes in ICUs.
MATERIALS AND METHODS:
By using a prospective observational-analytical design, medical data from 640 patients at a Karachi hospital for one year in 2022 were utilized. The study focused on antibiotic therapy, including empiric and targeted approaches, culture sensitivity testing, the use of the APACHE scale for mortality prediction, and changes in antibiotic regimens based on culture reports. Statistical analysis involved Fisher’s Exact and ANOVA tests.
RESULT:
The age category above 60 emerged with the highest survivorship. Contrary to expectations, age did not seem to correlate significantly with mortality rates. Staphylococcus species was the most prevalent microorganism in this study, disproportionately affecting nonsurvivors 66.7%. The clinical profile comparison between survivors and nonsurvivors offered a multifaceted perspective, with significant differences in vital parameters such as temperature, heart rate, respiratory rate, urine output, FiO2, mean arterial pH, and blood sugar levels. Survivors (44.60%) underwent complete antibiotic regimen changes, a strategy for improved patient outcomes.
CONCLUSIONS:
Complex antibiotic combinations were prescribed for broad clinical conditions. These insights pave the way for future research on antibiotic stewardship in ICUs, navigating more effective and targeted treatments. |
| format | Article |
| id | doaj-art-47d9e6ec7dbe4c59a701f16c878dd01d |
| institution | Kabale University |
| issn | 2277-9531 2319-6440 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Education and Health Promotion |
| spelling | doaj-art-47d9e6ec7dbe4c59a701f16c878dd01d2024-12-09T13:10:19ZengWolters Kluwer Medknow PublicationsJournal of Education and Health Promotion2277-95312319-64402024-11-0113142342310.4103/jehp.jehp_1833_23Precision medicine and patient outcomes in intensive care unit: Culture sensitivity, antibiotics, and APACHE score IVSidra ZubairSubia JamilSakina FatimaSyed T. SibtainHira RaeesAsma ErajAmber NawabBACKGROUND: In the intensive care unit (ICU), complex medical conditions require specialized care; the threat of antibiotic resistance is significant due to frequent antibiotic use. This study investigates the pivotal role of culture sensitivity testing in shaping antibiotic prescription practices and patient outcomes in ICUs. MATERIALS AND METHODS: By using a prospective observational-analytical design, medical data from 640 patients at a Karachi hospital for one year in 2022 were utilized. The study focused on antibiotic therapy, including empiric and targeted approaches, culture sensitivity testing, the use of the APACHE scale for mortality prediction, and changes in antibiotic regimens based on culture reports. Statistical analysis involved Fisher’s Exact and ANOVA tests. RESULT: The age category above 60 emerged with the highest survivorship. Contrary to expectations, age did not seem to correlate significantly with mortality rates. Staphylococcus species was the most prevalent microorganism in this study, disproportionately affecting nonsurvivors 66.7%. The clinical profile comparison between survivors and nonsurvivors offered a multifaceted perspective, with significant differences in vital parameters such as temperature, heart rate, respiratory rate, urine output, FiO2, mean arterial pH, and blood sugar levels. Survivors (44.60%) underwent complete antibiotic regimen changes, a strategy for improved patient outcomes. CONCLUSIONS: Complex antibiotic combinations were prescribed for broad clinical conditions. These insights pave the way for future research on antibiotic stewardship in ICUs, navigating more effective and targeted treatments.https://journals.lww.com/10.4103/jehp.jehp_1833_23antibiotic stewardshipapache score ivculture sensitivityintensive care unitmicroorganisms |
| spellingShingle | Sidra Zubair Subia Jamil Sakina Fatima Syed T. Sibtain Hira Raees Asma Eraj Amber Nawab Precision medicine and patient outcomes in intensive care unit: Culture sensitivity, antibiotics, and APACHE score IV Journal of Education and Health Promotion antibiotic stewardship apache score iv culture sensitivity intensive care unit microorganisms |
| title | Precision medicine and patient outcomes in intensive care unit: Culture sensitivity, antibiotics, and APACHE score IV |
| title_full | Precision medicine and patient outcomes in intensive care unit: Culture sensitivity, antibiotics, and APACHE score IV |
| title_fullStr | Precision medicine and patient outcomes in intensive care unit: Culture sensitivity, antibiotics, and APACHE score IV |
| title_full_unstemmed | Precision medicine and patient outcomes in intensive care unit: Culture sensitivity, antibiotics, and APACHE score IV |
| title_short | Precision medicine and patient outcomes in intensive care unit: Culture sensitivity, antibiotics, and APACHE score IV |
| title_sort | precision medicine and patient outcomes in intensive care unit culture sensitivity antibiotics and apache score iv |
| topic | antibiotic stewardship apache score iv culture sensitivity intensive care unit microorganisms |
| url | https://journals.lww.com/10.4103/jehp.jehp_1833_23 |
| work_keys_str_mv | AT sidrazubair precisionmedicineandpatientoutcomesinintensivecareunitculturesensitivityantibioticsandapachescoreiv AT subiajamil precisionmedicineandpatientoutcomesinintensivecareunitculturesensitivityantibioticsandapachescoreiv AT sakinafatima precisionmedicineandpatientoutcomesinintensivecareunitculturesensitivityantibioticsandapachescoreiv AT syedtsibtain precisionmedicineandpatientoutcomesinintensivecareunitculturesensitivityantibioticsandapachescoreiv AT hiraraees precisionmedicineandpatientoutcomesinintensivecareunitculturesensitivityantibioticsandapachescoreiv AT asmaeraj precisionmedicineandpatientoutcomesinintensivecareunitculturesensitivityantibioticsandapachescoreiv AT ambernawab precisionmedicineandpatientoutcomesinintensivecareunitculturesensitivityantibioticsandapachescoreiv |