Common pollen and related allergen components in patients with allergic diseases in the Beijing area
BackgroundPollen is the most common outdoor allergen that causes allergic rhinitis and asthma, which seriously affects patient quality of life and extensive cross-reactivity occurs between pollen allergens.MethodsThe study enrolled 84 patients with respiratory allergies and at least one pollen aller...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Allergy |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/falgy.2024.1478392/full |
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| author | Yi-Bo Hou Yi-Bo Hou Jin-Lu Sun Jin-Lu Sun |
| author_facet | Yi-Bo Hou Yi-Bo Hou Jin-Lu Sun Jin-Lu Sun |
| author_sort | Yi-Bo Hou |
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| description | BackgroundPollen is the most common outdoor allergen that causes allergic rhinitis and asthma, which seriously affects patient quality of life and extensive cross-reactivity occurs between pollen allergens.MethodsThe study enrolled 84 patients with respiratory allergies and at least one pollen allergy who visited the clinic. Specific-IgE was detected via immunoblotting in the sera of patients with positive respiratory allergies to pollen. IgE of the components and cross-reactive carbohydrate determinants (CCD) were evaluated using a fluorescence-encoded microsphere assay.ResultsOur results suggest that Artemisia absinthium, Artemisia vulgaris, Humulus scandens, Amaranthus, Parietaria micrantha allergies are most common in the northern region, and that weed pollen remains the major pollen allergen in the northern region. Among the different age groups, the positive rate of Platanus pollen allergens was significantly higher in patients ≤18 years of age than in those aged >18 years (55.56% vs. 9.17%, χ² = 0.55, p < 0.027). Patients with allergic rhinitis and asthma had an increased positive rate for Betula pollen allergen (20.00% vs. 37.93 χ² = 7.87, p = 0.005) and Platanus pollen allergen (27.27% vs. 51.72%, χ² = 11.05, p = 0.0008) than those with allergic rhinitis alone, although the allergen positivity rate did not significantly differ between sexes. In addition, the positivity of sIgE of allergen components did not reveal a correlation with clinical symptoms and anti-CCD IgE positivity was 1.19% (1/84) among all patients.ConclusionThe study found the distribution characteristics of common pollen allergens in Beijing among patients of different ages and genders and with different allergic diseases, as well as the relationship between pollen allergen components and symptoms. The positivity rate of CCD for respiratory allergic diseases in Beijing was not high as well. |
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| institution | Kabale University |
| issn | 2673-6101 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Allergy |
| spelling | doaj-art-47cd12070a7d457eaec86afb78a772f02024-11-21T06:23:50ZengFrontiers Media S.A.Frontiers in Allergy2673-61012024-11-01510.3389/falgy.2024.14783921478392Common pollen and related allergen components in patients with allergic diseases in the Beijing areaYi-Bo Hou0Yi-Bo Hou1Jin-Lu Sun2Jin-Lu Sun3State Key Laboratory of Complex Severe and Rare Diseases, Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaBeijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Diseases, Allergy Department, National Clinical Research Center for Dermatologic and Immunologic Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaState Key Laboratory of Complex Severe and Rare Diseases, Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaBeijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Diseases, Allergy Department, National Clinical Research Center for Dermatologic and Immunologic Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaBackgroundPollen is the most common outdoor allergen that causes allergic rhinitis and asthma, which seriously affects patient quality of life and extensive cross-reactivity occurs between pollen allergens.MethodsThe study enrolled 84 patients with respiratory allergies and at least one pollen allergy who visited the clinic. Specific-IgE was detected via immunoblotting in the sera of patients with positive respiratory allergies to pollen. IgE of the components and cross-reactive carbohydrate determinants (CCD) were evaluated using a fluorescence-encoded microsphere assay.ResultsOur results suggest that Artemisia absinthium, Artemisia vulgaris, Humulus scandens, Amaranthus, Parietaria micrantha allergies are most common in the northern region, and that weed pollen remains the major pollen allergen in the northern region. Among the different age groups, the positive rate of Platanus pollen allergens was significantly higher in patients ≤18 years of age than in those aged >18 years (55.56% vs. 9.17%, χ² = 0.55, p < 0.027). Patients with allergic rhinitis and asthma had an increased positive rate for Betula pollen allergen (20.00% vs. 37.93 χ² = 7.87, p = 0.005) and Platanus pollen allergen (27.27% vs. 51.72%, χ² = 11.05, p = 0.0008) than those with allergic rhinitis alone, although the allergen positivity rate did not significantly differ between sexes. In addition, the positivity of sIgE of allergen components did not reveal a correlation with clinical symptoms and anti-CCD IgE positivity was 1.19% (1/84) among all patients.ConclusionThe study found the distribution characteristics of common pollen allergens in Beijing among patients of different ages and genders and with different allergic diseases, as well as the relationship between pollen allergen components and symptoms. The positivity rate of CCD for respiratory allergic diseases in Beijing was not high as well.https://www.frontiersin.org/articles/10.3389/falgy.2024.1478392/fullpollenallergen componentsallergic diseasescomponent-resolved diagnosisCCD |
| spellingShingle | Yi-Bo Hou Yi-Bo Hou Jin-Lu Sun Jin-Lu Sun Common pollen and related allergen components in patients with allergic diseases in the Beijing area Frontiers in Allergy pollen allergen components allergic diseases component-resolved diagnosis CCD |
| title | Common pollen and related allergen components in patients with allergic diseases in the Beijing area |
| title_full | Common pollen and related allergen components in patients with allergic diseases in the Beijing area |
| title_fullStr | Common pollen and related allergen components in patients with allergic diseases in the Beijing area |
| title_full_unstemmed | Common pollen and related allergen components in patients with allergic diseases in the Beijing area |
| title_short | Common pollen and related allergen components in patients with allergic diseases in the Beijing area |
| title_sort | common pollen and related allergen components in patients with allergic diseases in the beijing area |
| topic | pollen allergen components allergic diseases component-resolved diagnosis CCD |
| url | https://www.frontiersin.org/articles/10.3389/falgy.2024.1478392/full |
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