The effect of NLRP3 inflammasome on cardiovascular prognosis in patients with acute coronary syndrome
Abstract The NOD‑like receptor protein domain associated protein 3 (NLRP3) inflammasome is critical in inflammatory responses and may be a valuable prognostic biomarker in acute coronary syndrome (ACS). We aimed to investigate the association between NLRP3 inflammasome levels and short-term outcomes...
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-85041-4 |
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| author | De-Gang Mo Ming-Ting Liang Li Xu Tai Li Qian-Feng Han Chen Chen Heng-Chen Yao |
| author_facet | De-Gang Mo Ming-Ting Liang Li Xu Tai Li Qian-Feng Han Chen Chen Heng-Chen Yao |
| author_sort | De-Gang Mo |
| collection | DOAJ |
| description | Abstract The NOD‑like receptor protein domain associated protein 3 (NLRP3) inflammasome is critical in inflammatory responses and may be a valuable prognostic biomarker in acute coronary syndrome (ACS). We aimed to investigate the association between NLRP3 inflammasome levels and short-term outcomes in patients with ACS. We enrolled 295 patients with ACS who were monitored for 6 months for major adverse cardiovascular events (MACEs). The NLRP3 inflammasome was quantified using enzyme-linked immunosorbent assays, with the Gensini score used to assess disease severity. A Cox regression model evaluated whether NLRP3 inflammasome levels were independent predictors of MACEs. Spearman correlation analysis demonstrated a significant positive correlation between NLRP3 inflammasome levels and the Gensini score (r = 0.55, p < 0.001). Plasma NLRP3 inflammasome levels were significantly higher in the MACEs group (8.48 ng/mL) compared with the no-MACEs group (3.48 ng/mL) (p < 0.001). Multivariate Cox regression identified NLRP3 inflammasome content as an independent risk factor for MACEs (hazard ratio 1.104, p = 0.001; area under the curve: 0.780 [95% confidence interval 0.721–0.840], p < 0.001). Elevated plasma NLRP3 inflammasome levels correlated with ACS severity and were associated with poorer short-term outcomes in patients with ACS. |
| format | Article |
| id | doaj-art-47bce171c83d4711b1cad1440a780dde |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-47bce171c83d4711b1cad1440a780dde2025-01-12T12:14:30ZengNature PortfolioScientific Reports2045-23222025-01-0115111210.1038/s41598-024-85041-4The effect of NLRP3 inflammasome on cardiovascular prognosis in patients with acute coronary syndromeDe-Gang Mo0Ming-Ting Liang1Li Xu2Tai Li3Qian-Feng Han4Chen Chen5Heng-Chen Yao6Department of Cardiology, Qingdao UniversityDepartment of Cardiology, Liaocheng People’s Hospital Affiliated to Shandong First Medical UniversityThe Institute for Tissue Engineering and Regenerative Medicine, Liaocheng People’s HospitalDepartment of Nursing, Liaocheng Vocational & Technical CollegeDepartment of Cardiology, Liaocheng People’s Hospital Affiliated to Shandong First Medical UniversityDepartment of Urology, Liaocheng People’s Hospital Affiliated to Shandong First Medical UniversityDepartment of Cardiology, Liaocheng People’s Hospital Affiliated to Shandong First Medical UniversityAbstract The NOD‑like receptor protein domain associated protein 3 (NLRP3) inflammasome is critical in inflammatory responses and may be a valuable prognostic biomarker in acute coronary syndrome (ACS). We aimed to investigate the association between NLRP3 inflammasome levels and short-term outcomes in patients with ACS. We enrolled 295 patients with ACS who were monitored for 6 months for major adverse cardiovascular events (MACEs). The NLRP3 inflammasome was quantified using enzyme-linked immunosorbent assays, with the Gensini score used to assess disease severity. A Cox regression model evaluated whether NLRP3 inflammasome levels were independent predictors of MACEs. Spearman correlation analysis demonstrated a significant positive correlation between NLRP3 inflammasome levels and the Gensini score (r = 0.55, p < 0.001). Plasma NLRP3 inflammasome levels were significantly higher in the MACEs group (8.48 ng/mL) compared with the no-MACEs group (3.48 ng/mL) (p < 0.001). Multivariate Cox regression identified NLRP3 inflammasome content as an independent risk factor for MACEs (hazard ratio 1.104, p = 0.001; area under the curve: 0.780 [95% confidence interval 0.721–0.840], p < 0.001). Elevated plasma NLRP3 inflammasome levels correlated with ACS severity and were associated with poorer short-term outcomes in patients with ACS.https://doi.org/10.1038/s41598-024-85041-4Acute coronary syndromeNLRP3 inflammasomeShort-term prognosis |
| spellingShingle | De-Gang Mo Ming-Ting Liang Li Xu Tai Li Qian-Feng Han Chen Chen Heng-Chen Yao The effect of NLRP3 inflammasome on cardiovascular prognosis in patients with acute coronary syndrome Scientific Reports Acute coronary syndrome NLRP3 inflammasome Short-term prognosis |
| title | The effect of NLRP3 inflammasome on cardiovascular prognosis in patients with acute coronary syndrome |
| title_full | The effect of NLRP3 inflammasome on cardiovascular prognosis in patients with acute coronary syndrome |
| title_fullStr | The effect of NLRP3 inflammasome on cardiovascular prognosis in patients with acute coronary syndrome |
| title_full_unstemmed | The effect of NLRP3 inflammasome on cardiovascular prognosis in patients with acute coronary syndrome |
| title_short | The effect of NLRP3 inflammasome on cardiovascular prognosis in patients with acute coronary syndrome |
| title_sort | effect of nlrp3 inflammasome on cardiovascular prognosis in patients with acute coronary syndrome |
| topic | Acute coronary syndrome NLRP3 inflammasome Short-term prognosis |
| url | https://doi.org/10.1038/s41598-024-85041-4 |
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