FGF21 ameliorates diabetic nephropathy through CDK1-dependently regulating the cell cycle

FGF21 ameliorates diabetic nephropathy through CDK1-dependently regulating the cell cycle

BackgroundDiabetic nephropathy (DN) is a prevalent global renal illness and one of the main causes of end-stage renal disease (ESRD). FGF21 has been shown to ameliorate diabetic nephropathy, and in addition FGF-21-treated mice impeded mitogenicity, whereas it is unclear whether FGF21 can influence D...

Full description

Saved in:

Bibliographic Details
Main Authors:	Yudie Zhang, Fan Wang, Chongyang Zhang, Fan Yao, Bin Zhang, Yongping Zhang, Xiaobo Sun
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-01-01
Series:	Frontiers in Pharmacology
Subjects:	FGF21 diabetic nephropathy CDK1 cell cycle glomerular filtration barrier
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1500458/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Circulating FGF21 is lower in South Asians compared with Europids with type 2 diabetes mellitus
by: Carlijn A Hoekx, et al.
Published: (2025-01-01)

FGF21 acts in the brain to drive macronutrient-specific changes in behavioral motivation and brain reward signaling
by: Md Shahjalal H. Khan, et al.
Published: (2025-01-01)

Dual Inhibition of CDK4/6 and CDK7 Suppresses Triple‐Negative Breast Cancer Progression via Epigenetic Modulation of SREBP1‐Regulated Cholesterol Metabolism
by: Yilan Yang, et al.
Published: (2025-02-01)

Estradiol-dependent and independent effects of FGF21 in obese female mice
by: T. V. Jakovleva, et al.
Published: (2022-04-01)

GPX4 expression changes in proximal tubule cells highlight the role of ferroptosis in IgAN
by: Jianbo Qing, et al.
Published: (2025-01-01)

Transcriptome integration analysis revealed that miR-103-3p regulates goat myoblast proliferation by targeting FGF18
by: Kunyu Li, et al.
Published: (2025-01-01)

ＦＧＦ２１在小鼠非酒精性脂肪肝病程中的变化及与ＳＲＥＢＰ的相关性
by: 郭云蔚
Published: (2016-01-01)

Machine learning-enhanced high-resolution exposure assessment of ultrafine particles
by: Yudie Jianyao, et al.
Published: (2025-01-01)

FGF21 and APOA1 mRNA-based therapies for the treatment of experimental acute pancreatitis
by: Amaya Lopez-Pascual, et al.
Published: (2025-01-01)

Nailfold capillary abnormalities as indicators of diabetic nephropathy progression: a cross-sectional study in type 2 diabetes
by: Po-Chi Hsu, et al.
Published: (2025-12-01)

Inducible Fgf13 ablation alleviates cardiac fibrosis via regulation of microtubule stability
by: Wang Cong, et al.
Published: (2024-05-01)

CDK12 antagonizes a viral suppressor of RNAi to modulate antiviral RNAi in Drosophila
by: Liqin Zhang, et al.
Published: (2025-01-01)

Untargeted metabolomic and proteomic analysis implicates SIRT2 as a novel therapeutic target for diabetic nephropathy
by: Ruijing Zhang, et al.
Published: (2025-02-01)

Curcumin nanocrystals ameliorate ferroptosis of diabetic nephropathy through glutathione peroxidase 4
by: Mengjiao Xue, et al.
Published: (2025-01-01)

Evaluating plasma biomarkers NfL, GFAP, GDF15, and FGF21 as indicators of disease severity in Charcot–Marie Tooth patients
by: Dace Pretkalnina, et al.
Published: (2025-01-01)

Identification of circRNA/miRNA/mRNA regulatory network involving (+)-catechin ameliorates diabetic nephropathy mice
by: Chao Chen, et al.
Published: (2022-05-01)

VEGFR3 mitigates hypertensive nephropathy by enhancing mitophagy via regulating crotonylation of HSPA1L
by: Qiuwen Wu, et al.
Published: (2025-01-01)

Corrigendum: Notoginsenoside R1 protects against diabetic cardiomyopathy through activating estrogen receptor α and its downstream signaling
by: Bin Zhang, et al.
Published: (2025-01-01)

Various endurance training intensities improve GFR and Up-regulate AQP2/GSK3β in lithium-induced nephropathic rats
by: Shadan Saberi, et al.
Published: (2025-02-01)

Interrelation of Natural Polyphenol and Fibrosis in Diabetic Nephropathy
by: Ye Ma, et al.
Published: (2024-12-01)

Application of multi-antenna technology based on the indoor scene
by: Chongyang LI, et al.
Published: (2017-07-01)

Environmental high temperature (heat stroke) causes articular cartilage damage in vivo and in vitro
by: Sun yingfei, et al.
Published: (2025-01-01)

Advancing the application of the analytical renal pathology system in allograft IgA nephropathy patients
by: Xumeng Liu, et al.
Published: (2024-12-01)

Delivery of FGF18 using mRNA-LNP protects the cartilage against degeneration via alleviating chondrocyte senescence
by: Keyu Kong, et al.
Published: (2025-01-01)

Epigenome-wide association study of Chinese monozygotic twins identifies DNA methylation loci associated with estimated glomerular filtration rate
by: Xueting Qi, et al.
Published: (2025-01-01)

Assessment of renal insufficiency in patients with renal artery stenosis by multiparametric magnetic resonance imaging
by: Long Zhao, et al.
Published: (2025-12-01)

Long-term Follow-up of Patients Undergoing Nephrectomy for Urolithiasis
by: Thiago Augusto Cunha Ferreira, et al.
Published: (2025-01-01)

Evaluation of glomerular filtration rate estimation through plasma clearance of iohexol in seagulls (Larus michahellis)
by: Matilde Vernaccini, et al.
Published: (2025-01-01)

Efficacy and safety of tripterygium glycosides combined with ACEI/ARB on diabetic nephropathy: a meta-analysis
by: Zhuan’E. Yao, et al.
Published: (2025-01-01)

Genetic association analysis of lipid-lowering drug target genes in chronic kidney disease
by: Yi Zhang, et al.
Published: (2025-01-01)

A New Unified Solution for Deep Tunnels in Water-Rich Areas considering Pore Water Pressure
by: Hao Fan, et al.
Published: (2021-01-01)

Causal relationship between 412 gut microbiota, 1,400 blood metabolites, and diabetic nephropathy: a randomized Mendelian study
by: Bo-Ning Cao, et al.
Published: (2025-01-01)

The role of the estimated glomerular filtration rate and body roundness index in the risk assessment of uric acid-lowering therapy-resistant gout in U.S. adults: evidence from the National Health and Nutrition Examination Survey (2007–2018)
by: Mengyuan Zhu, et al.
Published: (2025-12-01)

Induction of cell cycle arrest via the p21, p27–cyclin E,A/Cdk2 pathway in SMMC-7721 hepatoma cells by clioquinol
by: Huang Zhiwei, et al.
Published: (2015-12-01)

Stability Analysis of a Water-Rich Slope Under Seismic Disturbance
by: Shujian Li, et al.
Published: (2024-01-01)

Current perspectives and trends of the research on hypertensive nephropathy: a bibliometric analysis from 2000 to 2023
by: Lan Wang, et al.
Published: (2024-12-01)

Oridonin ameliorates renal fibrosis in diabetic nephropathy by inhibiting the Wnt/β-catenin signaling pathway
by: Jushuang Li, et al.
Published: (2024-12-01)

Correlation between serum homocysteine level and clinicopathological factors of IgA nephropathy
by: Cai Xiao-fan, et al.
Published: (2025-01-01)

Pedestrian trajectory prediction method based on group perception
by: WANG Ruyan, et al.
Published: (2024-12-01)

Biosynthesis inhibition of miR-142-5p in a N 6-methyladenosine-dependent manner induces neuropathic pain through CDK5/TRPV1 signaling
by: Jinshi Li, et al.
Published: (2025-01-01)