Unraveling the role of gut microbiota and immune cells in thyroid cancer and tumor drug resistance
Abstract The gut microbiota (GM) and immune cells (IC) are increasingly recognized as key players in cancer development and progression. This study aimed to explore the potential mediating role of IC in the causal relationship between GM and thyroid cancer (TC) using Mendelian randomization (MR) ana...
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| Format: | Article |
| Language: | English |
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Springer
2024-11-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-024-01585-x |
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| author | Jiaqin Deng Yihua Gu Ming Yu Yeqian Lai Lihong Qiu |
| author_facet | Jiaqin Deng Yihua Gu Ming Yu Yeqian Lai Lihong Qiu |
| author_sort | Jiaqin Deng |
| collection | DOAJ |
| description | Abstract The gut microbiota (GM) and immune cells (IC) are increasingly recognized as key players in cancer development and progression. This study aimed to explore the potential mediating role of IC in the causal relationship between GM and thyroid cancer (TC) using Mendelian randomization (MR) analysis. Data from genome-wide association studies (GWAS) encompassing 473 GM species, 731 IC types, and TC were utilized. MR analysis identified nine GM species with significant causal relationships to TC, mediated by 10 IC phenotypes such as "Switched Memory AC," "IgD-CD38dim AC," and "EM DN (CD4-CD8-) AC." These findings suggest a complex interplay where specific IC mediate the effects of GM on TC risk. Sensitivity analyses confirmed the robustness of these results, with no evidence of horizontal pleiotropy. This study highlights potential mechanisms linking GM and IC to TC, offering insights that could inform GM-based immunotherapeutic strategies and IC-targeted interventions. However, further experimental research is needed to validate these causal pathways and better understand the underlying biological mechanisms. |
| format | Article |
| id | doaj-art-47a9c4e4346b42f8b94b92bd4b64bb69 |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-47a9c4e4346b42f8b94b92bd4b64bb692024-11-24T12:32:02ZengSpringerDiscover Oncology2730-60112024-11-0115111210.1007/s12672-024-01585-xUnraveling the role of gut microbiota and immune cells in thyroid cancer and tumor drug resistanceJiaqin Deng0Yihua Gu1Ming Yu2Yeqian Lai3Lihong Qiu4Department of Thyroid Surgery, Meizhou People’s Hospital, Meizhou Academy of Medical SciencesDepartment of Thyroid Surgery, Meizhou People’s Hospital, Meizhou Academy of Medical SciencesDepartment of Thyroid Surgery, Meizhou People’s Hospital, Meizhou Academy of Medical SciencesDepartment of Thyroid Surgery, Meizhou People’s Hospital, Meizhou Academy of Medical SciencesDepartment of Clinical Laboratory, Affiliated Hospital of Guangdong Medical UniversityAbstract The gut microbiota (GM) and immune cells (IC) are increasingly recognized as key players in cancer development and progression. This study aimed to explore the potential mediating role of IC in the causal relationship between GM and thyroid cancer (TC) using Mendelian randomization (MR) analysis. Data from genome-wide association studies (GWAS) encompassing 473 GM species, 731 IC types, and TC were utilized. MR analysis identified nine GM species with significant causal relationships to TC, mediated by 10 IC phenotypes such as "Switched Memory AC," "IgD-CD38dim AC," and "EM DN (CD4-CD8-) AC." These findings suggest a complex interplay where specific IC mediate the effects of GM on TC risk. Sensitivity analyses confirmed the robustness of these results, with no evidence of horizontal pleiotropy. This study highlights potential mechanisms linking GM and IC to TC, offering insights that could inform GM-based immunotherapeutic strategies and IC-targeted interventions. However, further experimental research is needed to validate these causal pathways and better understand the underlying biological mechanisms.https://doi.org/10.1007/s12672-024-01585-xGut microbiotaImmune cellsThyroid cancerMendelian randomizationMediation analysis |
| spellingShingle | Jiaqin Deng Yihua Gu Ming Yu Yeqian Lai Lihong Qiu Unraveling the role of gut microbiota and immune cells in thyroid cancer and tumor drug resistance Discover Oncology Gut microbiota Immune cells Thyroid cancer Mendelian randomization Mediation analysis |
| title | Unraveling the role of gut microbiota and immune cells in thyroid cancer and tumor drug resistance |
| title_full | Unraveling the role of gut microbiota and immune cells in thyroid cancer and tumor drug resistance |
| title_fullStr | Unraveling the role of gut microbiota and immune cells in thyroid cancer and tumor drug resistance |
| title_full_unstemmed | Unraveling the role of gut microbiota and immune cells in thyroid cancer and tumor drug resistance |
| title_short | Unraveling the role of gut microbiota and immune cells in thyroid cancer and tumor drug resistance |
| title_sort | unraveling the role of gut microbiota and immune cells in thyroid cancer and tumor drug resistance |
| topic | Gut microbiota Immune cells Thyroid cancer Mendelian randomization Mediation analysis |
| url | https://doi.org/10.1007/s12672-024-01585-x |
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