PATHOGENETIC ROLE OF ABZYME-TYPE AUTOANTIBODIES IN THE ORGAN-SPECIFIC AUTOIMMUNE PATHOLOGY
Abstract. The work deals with quantitative methods developed for estimation of nuclease and proteolytic activities of autoantibodies. By means of these techniques, appropriate catalytic activities of abzyme-type antibodies were studied in patients with diabetes mellitus type 1, and in su...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
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| Online Access: | https://www.mimmun.ru/mimmun/article/view/491 |
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| author | L. N. Luchverchyk N. V. Piven A. I. Burakovsky |
| author_facet | L. N. Luchverchyk N. V. Piven A. I. Burakovsky |
| author_sort | L. N. Luchverchyk |
| collection | DOAJ |
| description | Abstract. The work deals with quantitative methods developed for estimation of nuclease and proteolytic activities of autoantibodies. By means of these techniques, appropriate catalytic activities of abzyme-type antibodies were studied in patients with diabetes mellitus type 1, and in subjects with autoimmune thyroiditis. Oppositely directed changes of the mentioned catalytic activities have been found for autoantibodies of different specificity. Autoantibodies occurring in autoimmune thyroiditis showed an increase of both nuclease and proteolytic activities. Meanwhile, the autoantibodies in diabetes mellitus had increased nuclease activity, along with decreased proteolytic activity. These findings are suggestive for existence of two pathogenetic mechanisms in organ-specific autoimmune pathology that are associated either with direct involvement of Fab fragments of auto-antibodies in autoimmune destruction, or with complement-dependent lysis mediated by Fc-fragments and cytotoxic destruction of target cells by cytotoxic T-lymphocytes. The unique site-specific catalytic autoantibodies were established to exert a selective destructive effect upon target cells, thus making a major contribution to the antibody-dependent mechanisms of cytotoxicity in autoimmune diseases. (Med. Immunol., 2011, vol. 13, N 2-3, pp 145-150) |
| format | Article |
| id | doaj-art-479b978e17d6476fa5514b037a0965a8 |
| institution | Kabale University |
| issn | 1563-0625 2313-741X |
| language | Russian |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj-art-479b978e17d6476fa5514b037a0965a82025-08-20T04:00:09ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-01132-314515010.15789/1563-0625-2011-2-3-145-150488PATHOGENETIC ROLE OF ABZYME-TYPE AUTOANTIBODIES IN THE ORGAN-SPECIFIC AUTOIMMUNE PATHOLOGYL. N. Luchverchyk0N. V. Piven1A. I. Burakovsky2ГНУ «Институт биоорганической химии НАН Беларуси», г. МинскГНУ «Институт биоорганической химии НАН Беларуси», г. МинскГНУ «Институт биоорганической химии НАН Беларуси», г. МинскAbstract. The work deals with quantitative methods developed for estimation of nuclease and proteolytic activities of autoantibodies. By means of these techniques, appropriate catalytic activities of abzyme-type antibodies were studied in patients with diabetes mellitus type 1, and in subjects with autoimmune thyroiditis. Oppositely directed changes of the mentioned catalytic activities have been found for autoantibodies of different specificity. Autoantibodies occurring in autoimmune thyroiditis showed an increase of both nuclease and proteolytic activities. Meanwhile, the autoantibodies in diabetes mellitus had increased nuclease activity, along with decreased proteolytic activity. These findings are suggestive for existence of two pathogenetic mechanisms in organ-specific autoimmune pathology that are associated either with direct involvement of Fab fragments of auto-antibodies in autoimmune destruction, or with complement-dependent lysis mediated by Fc-fragments and cytotoxic destruction of target cells by cytotoxic T-lymphocytes. The unique site-specific catalytic autoantibodies were established to exert a selective destructive effect upon target cells, thus making a major contribution to the antibody-dependent mechanisms of cytotoxicity in autoimmune diseases. (Med. Immunol., 2011, vol. 13, N 2-3, pp 145-150)https://www.mimmun.ru/mimmun/article/view/491autoimmune disordersdiabetes mellitusautoimmune thyroiditisabzyme-type autoantibodiescatalytic activity |
| spellingShingle | L. N. Luchverchyk N. V. Piven A. I. Burakovsky PATHOGENETIC ROLE OF ABZYME-TYPE AUTOANTIBODIES IN THE ORGAN-SPECIFIC AUTOIMMUNE PATHOLOGY Медицинская иммунология autoimmune disorders diabetes mellitus autoimmune thyroiditis abzyme-type autoantibodies catalytic activity |
| title | PATHOGENETIC ROLE OF ABZYME-TYPE AUTOANTIBODIES IN THE ORGAN-SPECIFIC AUTOIMMUNE PATHOLOGY |
| title_full | PATHOGENETIC ROLE OF ABZYME-TYPE AUTOANTIBODIES IN THE ORGAN-SPECIFIC AUTOIMMUNE PATHOLOGY |
| title_fullStr | PATHOGENETIC ROLE OF ABZYME-TYPE AUTOANTIBODIES IN THE ORGAN-SPECIFIC AUTOIMMUNE PATHOLOGY |
| title_full_unstemmed | PATHOGENETIC ROLE OF ABZYME-TYPE AUTOANTIBODIES IN THE ORGAN-SPECIFIC AUTOIMMUNE PATHOLOGY |
| title_short | PATHOGENETIC ROLE OF ABZYME-TYPE AUTOANTIBODIES IN THE ORGAN-SPECIFIC AUTOIMMUNE PATHOLOGY |
| title_sort | pathogenetic role of abzyme type autoantibodies in the organ specific autoimmune pathology |
| topic | autoimmune disorders diabetes mellitus autoimmune thyroiditis abzyme-type autoantibodies catalytic activity |
| url | https://www.mimmun.ru/mimmun/article/view/491 |
| work_keys_str_mv | AT lnluchverchyk pathogeneticroleofabzymetypeautoantibodiesintheorganspecificautoimmunepathology AT nvpiven pathogeneticroleofabzymetypeautoantibodiesintheorganspecificautoimmunepathology AT aiburakovsky pathogeneticroleofabzymetypeautoantibodiesintheorganspecificautoimmunepathology |