Exploring the diversity of cannabis cannabinoid and non-cannabinoid compounds and their roles in Alzheimer's disease: A review
Cannabis sativa is recognized for its chemical diversity and therapeutic potential, particularly in addressing neurodegenerative diseases such as Alzheimer's disease (AD). Given the complexity of AD, where single-target therapies often prove inadequate, a multi-target approach utilizing cannabi...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | IBRO Neuroscience Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667242124001192 |
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| author | Hanane Doumar Hicham El Mostafi Aboubaker Elhessni Mohamed Ebn Touhami Abdelhalem Mesfioui |
| author_facet | Hanane Doumar Hicham El Mostafi Aboubaker Elhessni Mohamed Ebn Touhami Abdelhalem Mesfioui |
| author_sort | Hanane Doumar |
| collection | DOAJ |
| description | Cannabis sativa is recognized for its chemical diversity and therapeutic potential, particularly in addressing neurodegenerative diseases such as Alzheimer's disease (AD). Given the complexity of AD, where single-target therapies often prove inadequate, a multi-target approach utilizing cannabis-derived compounds may offer promising alternatives. This review first highlights the chemical diversity of cannabis by categorizing its compounds into cannabinoids and non-cannabinoids. It then examines studies investigating the effects of these compounds on AD-related pathological features. By synthesizing existing knowledge, identifying research gaps, and facilitating comparative analysis, this review aims to advance future research and understanding. It underscores cannabis's potential as a multi-target therapeutic strategy for AD, contributing valuable insights to ongoing scientific discussions. |
| format | Article |
| id | doaj-art-47984fb509dc447282a223a910a026be |
| institution | Kabale University |
| issn | 2667-2421 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IBRO Neuroscience Reports |
| spelling | doaj-art-47984fb509dc447282a223a910a026be2025-01-09T06:14:54ZengElsevierIBRO Neuroscience Reports2667-24212025-06-011896119Exploring the diversity of cannabis cannabinoid and non-cannabinoid compounds and their roles in Alzheimer's disease: A reviewHanane Doumar0Hicham El Mostafi1Aboubaker Elhessni2Mohamed Ebn Touhami3Abdelhalem Mesfioui4Laboratory of Biology and Health, Department of Biology, Faculty of Sciences, Ibn Tofail University, Kenitra, MoroccoLaboratory of Biology and Health, Department of Biology, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco; Correspondence to: Biology and Health Laboratory, Department of Biology, Faculty of Sciences, Ibn Tofail University, B.P 133, Kenitra 14000, Morocco.Laboratory of Biology and Health, Department of Biology, Faculty of Sciences, Ibn Tofail University, Kenitra, MoroccoLaboratory of Materials Engineering and Environment: Modeling and Application, Department of Chemistry, Faculty of Sciences, Ibn Tofail University, Kenitra, MoroccoLaboratory of Biology and Health, Department of Biology, Faculty of Sciences, Ibn Tofail University, Kenitra, MoroccoCannabis sativa is recognized for its chemical diversity and therapeutic potential, particularly in addressing neurodegenerative diseases such as Alzheimer's disease (AD). Given the complexity of AD, where single-target therapies often prove inadequate, a multi-target approach utilizing cannabis-derived compounds may offer promising alternatives. This review first highlights the chemical diversity of cannabis by categorizing its compounds into cannabinoids and non-cannabinoids. It then examines studies investigating the effects of these compounds on AD-related pathological features. By synthesizing existing knowledge, identifying research gaps, and facilitating comparative analysis, this review aims to advance future research and understanding. It underscores cannabis's potential as a multi-target therapeutic strategy for AD, contributing valuable insights to ongoing scientific discussions.http://www.sciencedirect.com/science/article/pii/S2667242124001192Cannabis sativaAlzheimer's diseaseNeuroprotectionCannabinoidsMulti-target therapy |
| spellingShingle | Hanane Doumar Hicham El Mostafi Aboubaker Elhessni Mohamed Ebn Touhami Abdelhalem Mesfioui Exploring the diversity of cannabis cannabinoid and non-cannabinoid compounds and their roles in Alzheimer's disease: A review IBRO Neuroscience Reports Cannabis sativa Alzheimer's disease Neuroprotection Cannabinoids Multi-target therapy |
| title | Exploring the diversity of cannabis cannabinoid and non-cannabinoid compounds and their roles in Alzheimer's disease: A review |
| title_full | Exploring the diversity of cannabis cannabinoid and non-cannabinoid compounds and their roles in Alzheimer's disease: A review |
| title_fullStr | Exploring the diversity of cannabis cannabinoid and non-cannabinoid compounds and their roles in Alzheimer's disease: A review |
| title_full_unstemmed | Exploring the diversity of cannabis cannabinoid and non-cannabinoid compounds and their roles in Alzheimer's disease: A review |
| title_short | Exploring the diversity of cannabis cannabinoid and non-cannabinoid compounds and their roles in Alzheimer's disease: A review |
| title_sort | exploring the diversity of cannabis cannabinoid and non cannabinoid compounds and their roles in alzheimer s disease a review |
| topic | Cannabis sativa Alzheimer's disease Neuroprotection Cannabinoids Multi-target therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2667242124001192 |
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