Hybrid adaptation is hampered by Haldane’s sieve
Abstract Hybrids between species exhibit plastic genomic architectures that could foster or slow down their adaptation. When challenged to evolve in an environment containing a UV mimetic drug, yeast hybrids have reduced adaptation rates compared to parents. We find that hybrids and their parents co...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-11-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-54105-4 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846147574510125056 |
|---|---|
| author | Carla Bautista Isabelle Gagnon-Arsenault Mariia Utrobina Anna Fijarczyk Devin P. Bendixsen Rike Stelkens Christian R. Landry |
| author_facet | Carla Bautista Isabelle Gagnon-Arsenault Mariia Utrobina Anna Fijarczyk Devin P. Bendixsen Rike Stelkens Christian R. Landry |
| author_sort | Carla Bautista |
| collection | DOAJ |
| description | Abstract Hybrids between species exhibit plastic genomic architectures that could foster or slow down their adaptation. When challenged to evolve in an environment containing a UV mimetic drug, yeast hybrids have reduced adaptation rates compared to parents. We find that hybrids and their parents converge onto similar molecular mechanisms of adaptation by mutations in pleiotropic transcription factors, but at a different pace. After 100 generations, mutations in these genes tend to be homozygous in the parents but heterozygous in the hybrids. We hypothesize that a lower rate of loss of heterozygosity (LOH) in hybrids could limit fitness gain. Using genome editing, we first demonstrate that mutations display incomplete dominance, requiring homozygosity to show full impact and to entirely circumvent Haldane’s sieve, which favors the fixation of dominant mutations. Second, tracking mutations in earlier generations confirmed a different rate of LOH in hybrids. Together, these findings show that Haldane’s sieve slows down adaptation in hybrids, revealing an intrinsic constraint of hybrid genomic architecture that can limit the role of hybridization in adaptive evolution. |
| format | Article |
| id | doaj-art-473340992c6f4f369da92ede7d70a2a9 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-473340992c6f4f369da92ede7d70a2a92024-12-01T12:36:21ZengNature PortfolioNature Communications2041-17232024-11-0115111610.1038/s41467-024-54105-4Hybrid adaptation is hampered by Haldane’s sieveCarla Bautista0Isabelle Gagnon-Arsenault1Mariia Utrobina2Anna Fijarczyk3Devin P. Bendixsen4Rike Stelkens5Christian R. Landry6Institut de Biologie Intégrative et des Systèmes (IBIS), Université LavalInstitut de Biologie Intégrative et des Systèmes (IBIS), Université LavalInstitut de Biologie Intégrative et des Systèmes (IBIS), Université LavalInstitut de Biologie Intégrative et des Systèmes (IBIS), Université LavalDepartment of Zoology, Stockholm UniversityDepartment of Zoology, Stockholm UniversityInstitut de Biologie Intégrative et des Systèmes (IBIS), Université LavalAbstract Hybrids between species exhibit plastic genomic architectures that could foster or slow down their adaptation. When challenged to evolve in an environment containing a UV mimetic drug, yeast hybrids have reduced adaptation rates compared to parents. We find that hybrids and their parents converge onto similar molecular mechanisms of adaptation by mutations in pleiotropic transcription factors, but at a different pace. After 100 generations, mutations in these genes tend to be homozygous in the parents but heterozygous in the hybrids. We hypothesize that a lower rate of loss of heterozygosity (LOH) in hybrids could limit fitness gain. Using genome editing, we first demonstrate that mutations display incomplete dominance, requiring homozygosity to show full impact and to entirely circumvent Haldane’s sieve, which favors the fixation of dominant mutations. Second, tracking mutations in earlier generations confirmed a different rate of LOH in hybrids. Together, these findings show that Haldane’s sieve slows down adaptation in hybrids, revealing an intrinsic constraint of hybrid genomic architecture that can limit the role of hybridization in adaptive evolution.https://doi.org/10.1038/s41467-024-54105-4 |
| spellingShingle | Carla Bautista Isabelle Gagnon-Arsenault Mariia Utrobina Anna Fijarczyk Devin P. Bendixsen Rike Stelkens Christian R. Landry Hybrid adaptation is hampered by Haldane’s sieve Nature Communications |
| title | Hybrid adaptation is hampered by Haldane’s sieve |
| title_full | Hybrid adaptation is hampered by Haldane’s sieve |
| title_fullStr | Hybrid adaptation is hampered by Haldane’s sieve |
| title_full_unstemmed | Hybrid adaptation is hampered by Haldane’s sieve |
| title_short | Hybrid adaptation is hampered by Haldane’s sieve |
| title_sort | hybrid adaptation is hampered by haldane s sieve |
| url | https://doi.org/10.1038/s41467-024-54105-4 |
| work_keys_str_mv | AT carlabautista hybridadaptationishamperedbyhaldanessieve AT isabellegagnonarsenault hybridadaptationishamperedbyhaldanessieve AT mariiautrobina hybridadaptationishamperedbyhaldanessieve AT annafijarczyk hybridadaptationishamperedbyhaldanessieve AT devinpbendixsen hybridadaptationishamperedbyhaldanessieve AT rikestelkens hybridadaptationishamperedbyhaldanessieve AT christianrlandry hybridadaptationishamperedbyhaldanessieve |