Corneal scarring after epithelium-off collagen cross-linking
Collagen cross-linking (CXL) is considered as a successful therapeutic approach for corneal conditions like keratoconus and corneal ectasia. Despite its efficacy in stabilizing these conditions, the occurrence of post-CXL scars remains a concern. Keratoconus and other corneal ectasias are characteri...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Indian Journal of Ophthalmology |
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| Online Access: | https://journals.lww.com/10.4103/IJO.IJO_95_24 |
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| author | Radhika Natarajan Divya Giridhar |
| author_facet | Radhika Natarajan Divya Giridhar |
| author_sort | Radhika Natarajan |
| collection | DOAJ |
| description | Collagen cross-linking (CXL) is considered as a successful therapeutic approach for corneal conditions like keratoconus and corneal ectasia. Despite its efficacy in stabilizing these conditions, the occurrence of post-CXL scars remains a concern. Keratoconus and other corneal ectasias are characterized by structural weaknesses in the cornea. This weakness contributes to the vulnerability of corneal scar formation. In addition, corneal biomechanics and tissue properties play a significant role in scar development. Procedural factors during CXL, including duration and intensity of ultraviolet light exposure, the concentration and type of riboflavin, and the precise application of treatment, have been identified as potential causes of scar formation. Individual patient factors such as variations in healing response and genetic predispositions, associated ocular allergy, and chronic contact lens wear can also impact scar development post-CXL. Understanding these variables is essential for risk stratification and personalized treatment approaches, ultimately optimizing patient outcomes. In addition, regular follow-up visits and patient education are essential to ensure optimal healing and minimize scar related complications. We have tried to explain the numerous reasons of scarring following epithelium-off CXL by conducting a thorough Medline search and reviewing our clinical images. This review serves as a concise overview of the causes and risk factors associated with scar formation after epithelium-off CXL. |
| format | Article |
| id | doaj-art-46e5e49df3b64300838b7c69a9ea6d38 |
| institution | Kabale University |
| issn | 0301-4738 1998-3689 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj-art-46e5e49df3b64300838b7c69a9ea6d382025-01-07T06:27:42ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892025-01-01731283410.4103/IJO.IJO_95_24Corneal scarring after epithelium-off collagen cross-linkingRadhika NatarajanDivya GiridharCollagen cross-linking (CXL) is considered as a successful therapeutic approach for corneal conditions like keratoconus and corneal ectasia. Despite its efficacy in stabilizing these conditions, the occurrence of post-CXL scars remains a concern. Keratoconus and other corneal ectasias are characterized by structural weaknesses in the cornea. This weakness contributes to the vulnerability of corneal scar formation. In addition, corneal biomechanics and tissue properties play a significant role in scar development. Procedural factors during CXL, including duration and intensity of ultraviolet light exposure, the concentration and type of riboflavin, and the precise application of treatment, have been identified as potential causes of scar formation. Individual patient factors such as variations in healing response and genetic predispositions, associated ocular allergy, and chronic contact lens wear can also impact scar development post-CXL. Understanding these variables is essential for risk stratification and personalized treatment approaches, ultimately optimizing patient outcomes. In addition, regular follow-up visits and patient education are essential to ensure optimal healing and minimize scar related complications. We have tried to explain the numerous reasons of scarring following epithelium-off CXL by conducting a thorough Medline search and reviewing our clinical images. This review serves as a concise overview of the causes and risk factors associated with scar formation after epithelium-off CXL.https://journals.lww.com/10.4103/IJO.IJO_95_24collagen cross-linkingrisk factorsscar |
| spellingShingle | Radhika Natarajan Divya Giridhar Corneal scarring after epithelium-off collagen cross-linking Indian Journal of Ophthalmology collagen cross-linking risk factors scar |
| title | Corneal scarring after epithelium-off collagen cross-linking |
| title_full | Corneal scarring after epithelium-off collagen cross-linking |
| title_fullStr | Corneal scarring after epithelium-off collagen cross-linking |
| title_full_unstemmed | Corneal scarring after epithelium-off collagen cross-linking |
| title_short | Corneal scarring after epithelium-off collagen cross-linking |
| title_sort | corneal scarring after epithelium off collagen cross linking |
| topic | collagen cross-linking risk factors scar |
| url | https://journals.lww.com/10.4103/IJO.IJO_95_24 |
| work_keys_str_mv | AT radhikanatarajan cornealscarringafterepitheliumoffcollagencrosslinking AT divyagiridhar cornealscarringafterepitheliumoffcollagencrosslinking |