Association of the Effect of Alcohol Consumption on Luteinizing Hormone (LH), Follicle-Stimulating Hormone (FSH), and Testosterone Hormones in Men: A Systematic Review and Meta-Analysis
Background: The present study is a systematic review and meta-analysis aiming to investigate the effects of alcohol consumption on male sex hormones in humans. Methods: We conducted searches on PubMed, Scopus, Science Direct, and Google Scholar from June 2020 to June 2022. We included observational...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | International Journal of Preventive Medicine |
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| Online Access: | https://journals.lww.com/10.4103/ijpvm.ijpvm_81_24 |
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| _version_ | 1841551876514906112 |
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| author | Mahmood Moosazadeh Keyvan Heydari Kimia Rasouli Soroush Azari Mahdi Afshari Saeed Barzegari Roja Nikaeen Maryam Kardan-Souraki Soghra Khani Farzaneh Motafeghi Aref Hoseini |
| author_facet | Mahmood Moosazadeh Keyvan Heydari Kimia Rasouli Soroush Azari Mahdi Afshari Saeed Barzegari Roja Nikaeen Maryam Kardan-Souraki Soghra Khani Farzaneh Motafeghi Aref Hoseini |
| author_sort | Mahmood Moosazadeh |
| collection | DOAJ |
| description | Background:
The present study is a systematic review and meta-analysis aiming to investigate the effects of alcohol consumption on male sex hormones in humans.
Methods:
We conducted searches on PubMed, Scopus, Science Direct, and Google Scholar from June 2020 to June 2022. We included observational studies (cohorts, case-controls, and cross-sectional studies) comparing FSH, LH, or testosterone levels in alcohol consumers versus non-consumers. Subgroup analysis based on alcohol intake levels was conducted to explore potential heterogeneity sources. The meta-analysis was done by STATA version 11. Seventeen studies met the criteria.
Results:
Combining data from these studies, the standardized mean differences for FSH, LH, and testosterone in alcohol-exposed versus non-exposed groups were −0.00 (95% CI: −0.099–0.099), 0.04 (95% CI: 0.00–0.12), and 0.03 (95% CI: −0.11–0.16), respectively, showing no statistical significance. Subgroup analysis indicated a significant difference in FSH levels between moderate/high and low alcohol consumption groups (−0.04, 95% CI: −0.08 to −0.00). Similarly, compared to non-exposed individuals, testosterone levels differed significantly in groups with moderate (0.22, 95% CI: 0.12–0.32) and low (0.19, 95% CI: 0.04–0.35) alcohol intake. Given the notable alterations observed in testosterone levels among individuals with alcohol use disorder and the associated feedback changes in LH levels, it has been concluded that alcohol overuse should be recognized as a factor with destructive effects.
Conclusions:
It is suggested that future research includes comprehensive studies to investigate the changes in the hypothalamus-pituitary-testis axis induced by alcohol consumption. |
| format | Article |
| id | doaj-art-46d4c7559487438db3aadcf34f9bb458 |
| institution | Kabale University |
| issn | 2008-7802 2008-8213 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | International Journal of Preventive Medicine |
| spelling | doaj-art-46d4c7559487438db3aadcf34f9bb4582025-01-09T15:36:12ZengWolters Kluwer Medknow PublicationsInternational Journal of Preventive Medicine2008-78022008-82132024-12-0115757510.4103/ijpvm.ijpvm_81_24Association of the Effect of Alcohol Consumption on Luteinizing Hormone (LH), Follicle-Stimulating Hormone (FSH), and Testosterone Hormones in Men: A Systematic Review and Meta-AnalysisMahmood MoosazadehKeyvan HeydariKimia RasouliSoroush AzariMahdi AfshariSaeed BarzegariRoja NikaeenMaryam Kardan-SourakiSoghra KhaniFarzaneh MotafeghiAref HoseiniBackground: The present study is a systematic review and meta-analysis aiming to investigate the effects of alcohol consumption on male sex hormones in humans. Methods: We conducted searches on PubMed, Scopus, Science Direct, and Google Scholar from June 2020 to June 2022. We included observational studies (cohorts, case-controls, and cross-sectional studies) comparing FSH, LH, or testosterone levels in alcohol consumers versus non-consumers. Subgroup analysis based on alcohol intake levels was conducted to explore potential heterogeneity sources. The meta-analysis was done by STATA version 11. Seventeen studies met the criteria. Results: Combining data from these studies, the standardized mean differences for FSH, LH, and testosterone in alcohol-exposed versus non-exposed groups were −0.00 (95% CI: −0.099–0.099), 0.04 (95% CI: 0.00–0.12), and 0.03 (95% CI: −0.11–0.16), respectively, showing no statistical significance. Subgroup analysis indicated a significant difference in FSH levels between moderate/high and low alcohol consumption groups (−0.04, 95% CI: −0.08 to −0.00). Similarly, compared to non-exposed individuals, testosterone levels differed significantly in groups with moderate (0.22, 95% CI: 0.12–0.32) and low (0.19, 95% CI: 0.04–0.35) alcohol intake. Given the notable alterations observed in testosterone levels among individuals with alcohol use disorder and the associated feedback changes in LH levels, it has been concluded that alcohol overuse should be recognized as a factor with destructive effects. Conclusions: It is suggested that future research includes comprehensive studies to investigate the changes in the hypothalamus-pituitary-testis axis induced by alcohol consumption.https://journals.lww.com/10.4103/ijpvm.ijpvm_81_24alcoholfollicle-stimulating hormonegonadal steroid hormonesinfertilityluteinizing hormonetestosterone |
| spellingShingle | Mahmood Moosazadeh Keyvan Heydari Kimia Rasouli Soroush Azari Mahdi Afshari Saeed Barzegari Roja Nikaeen Maryam Kardan-Souraki Soghra Khani Farzaneh Motafeghi Aref Hoseini Association of the Effect of Alcohol Consumption on Luteinizing Hormone (LH), Follicle-Stimulating Hormone (FSH), and Testosterone Hormones in Men: A Systematic Review and Meta-Analysis International Journal of Preventive Medicine alcohol follicle-stimulating hormone gonadal steroid hormones infertility luteinizing hormone testosterone |
| title | Association of the Effect of Alcohol Consumption on Luteinizing Hormone (LH), Follicle-Stimulating Hormone (FSH), and Testosterone Hormones in Men: A Systematic Review and Meta-Analysis |
| title_full | Association of the Effect of Alcohol Consumption on Luteinizing Hormone (LH), Follicle-Stimulating Hormone (FSH), and Testosterone Hormones in Men: A Systematic Review and Meta-Analysis |
| title_fullStr | Association of the Effect of Alcohol Consumption on Luteinizing Hormone (LH), Follicle-Stimulating Hormone (FSH), and Testosterone Hormones in Men: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Association of the Effect of Alcohol Consumption on Luteinizing Hormone (LH), Follicle-Stimulating Hormone (FSH), and Testosterone Hormones in Men: A Systematic Review and Meta-Analysis |
| title_short | Association of the Effect of Alcohol Consumption on Luteinizing Hormone (LH), Follicle-Stimulating Hormone (FSH), and Testosterone Hormones in Men: A Systematic Review and Meta-Analysis |
| title_sort | association of the effect of alcohol consumption on luteinizing hormone lh follicle stimulating hormone fsh and testosterone hormones in men a systematic review and meta analysis |
| topic | alcohol follicle-stimulating hormone gonadal steroid hormones infertility luteinizing hormone testosterone |
| url | https://journals.lww.com/10.4103/ijpvm.ijpvm_81_24 |
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