Small-Animal Imaging Using Clinical Positron Emission Tomography/Computed Tomography and Super-Resolution
Considering the high cost of dedicated small-animal positron emission tomography/computed tomography (PET/CT), an acceptable alternative in many situations might be clinical PET/CT. However, spatial resolution and image quality are of concern. The utility of clinical PET/CT for small-animal research...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2012-05-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.2310/7290.2011.00041 |
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| _version_ | 1841563136875823104 |
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| author | Frank P. DiFilippo Sagar Patel Kewal Asosingh Serpil C. Erzurum |
| author_facet | Frank P. DiFilippo Sagar Patel Kewal Asosingh Serpil C. Erzurum |
| author_sort | Frank P. DiFilippo |
| collection | DOAJ |
| description | Considering the high cost of dedicated small-animal positron emission tomography/computed tomography (PET/CT), an acceptable alternative in many situations might be clinical PET/CT. However, spatial resolution and image quality are of concern. The utility of clinical PET/CT for small-animal research and image quality improvements from super-resolution (spatial subsampling) were investigated. National Electrical Manufacturers Association (NEMA) NU 4 phantom and mouse data were acquired with a clinical PET/CT scanner, as both conventional static and stepped scans. Static scans were reconstructed with and without point spread function (PSF) modeling. Stepped images were postprocessed with iterative deconvolution to produce super-resolution images. Image quality was markedly improved using the super-resolution technique, avoiding certain artifacts produced by PSF modeling. The 2 mm rod of the NU 4 phantom was visualized with high contrast, and the major structures of the mouse were well resolved. Although not a perfect substitute for a state-of-the-art small-animal PET/CT scanner, a clinical PET/CT scanner with super-resolution produces acceptable small-animal image quality for many preclinical research studies. |
| format | Article |
| id | doaj-art-46b6b7cdd5814c92b3e950b722e6ff1e |
| institution | Kabale University |
| issn | 1536-0121 |
| language | English |
| publishDate | 2012-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj-art-46b6b7cdd5814c92b3e950b722e6ff1e2025-01-03T00:11:34ZengSAGE PublishingMolecular Imaging1536-01212012-05-011110.2310/7290.2011.0004110.2310_7290.2011.00041Small-Animal Imaging Using Clinical Positron Emission Tomography/Computed Tomography and Super-ResolutionFrank P. DiFilippoSagar PatelKewal AsosinghSerpil C. ErzurumConsidering the high cost of dedicated small-animal positron emission tomography/computed tomography (PET/CT), an acceptable alternative in many situations might be clinical PET/CT. However, spatial resolution and image quality are of concern. The utility of clinical PET/CT for small-animal research and image quality improvements from super-resolution (spatial subsampling) were investigated. National Electrical Manufacturers Association (NEMA) NU 4 phantom and mouse data were acquired with a clinical PET/CT scanner, as both conventional static and stepped scans. Static scans were reconstructed with and without point spread function (PSF) modeling. Stepped images were postprocessed with iterative deconvolution to produce super-resolution images. Image quality was markedly improved using the super-resolution technique, avoiding certain artifacts produced by PSF modeling. The 2 mm rod of the NU 4 phantom was visualized with high contrast, and the major structures of the mouse were well resolved. Although not a perfect substitute for a state-of-the-art small-animal PET/CT scanner, a clinical PET/CT scanner with super-resolution produces acceptable small-animal image quality for many preclinical research studies.https://doi.org/10.2310/7290.2011.00041 |
| spellingShingle | Frank P. DiFilippo Sagar Patel Kewal Asosingh Serpil C. Erzurum Small-Animal Imaging Using Clinical Positron Emission Tomography/Computed Tomography and Super-Resolution Molecular Imaging |
| title | Small-Animal Imaging Using Clinical Positron Emission Tomography/Computed Tomography and Super-Resolution |
| title_full | Small-Animal Imaging Using Clinical Positron Emission Tomography/Computed Tomography and Super-Resolution |
| title_fullStr | Small-Animal Imaging Using Clinical Positron Emission Tomography/Computed Tomography and Super-Resolution |
| title_full_unstemmed | Small-Animal Imaging Using Clinical Positron Emission Tomography/Computed Tomography and Super-Resolution |
| title_short | Small-Animal Imaging Using Clinical Positron Emission Tomography/Computed Tomography and Super-Resolution |
| title_sort | small animal imaging using clinical positron emission tomography computed tomography and super resolution |
| url | https://doi.org/10.2310/7290.2011.00041 |
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