An ACE2 PET imaging agent derived from 18F/Cl exchange of MLN-4760 under phase transfer catalysis

An ACE2 PET imaging agent derived from 18F/Cl exchange of MLN-4760 under phase transfer catalysis

Abstract Background Angiotensin-converting enzyme-2 (ACE2) acts as a key regulatory molecule and important therapeutic target in the pathological remodeling of numerous organs and diseases. In this study, a rapid, simple, and efficient synthetic route with a catalytic, 18F-for-Cl (18F/Cl) exchange s...

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Bibliographic Details
Main Authors: Pan Zhou, Kai Ning, Shuai Xue, Qingqing Li, Danni Li, Haijun Yang, Zeying Liang, Rou Li, Jian Yang, Xiao Li, Lan Zhang
Format: Article
Language:English
Published: SpringerOpen 2024-12-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
MLN−4760
ACE2
18F/Cl exchange
PET imaging agent
Phase transfer catalysis
Online Access:https://doi.org/10.1186/s41181-024-00316-5
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