Longitudinal Assessment of Alterations in Peripheral Inflammatory Markers Over a Hospitalization Period in Patients with Schizophrenia
Objective: To assess the effects of regular medication administration, diet, sleep, and physical activity provided by hospital care on inflammatory markers in schizophrenia patients. The primary hypothesis of our study is that the assembly of various factors, will reduce low-grade inflammation in a...
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| Language: | English |
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Selcuk University Press
2023-12-01
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| Series: | Genel Tıp Dergisi |
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| Online Access: | https://dergipark.org.tr/tr/download/article-file/3266746 |
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| author | Süleyman Dönmezler Oya Güçlü İmren Kurt Halil Ibrahim Ozturk |
| author_facet | Süleyman Dönmezler Oya Güçlü İmren Kurt Halil Ibrahim Ozturk |
| author_sort | Süleyman Dönmezler |
| collection | DOAJ |
| description | Objective: To assess the effects of regular medication administration, diet, sleep, and physical activity provided by hospital care on inflammatory markers in schizophrenia patients. The primary hypothesis of our study is that the assembly of various factors, will reduce low-grade inflammation in a short period.
Materials and Methods: This retrospective longitudinal study involved 106 patients diagnosed with schizophrenia who met the exclusion and inclusion criteria. Inflammatory markers such as neutrophil-to-lymphocyte Ratios (NLR), monocyte-to-lymphocyte ratios (MLR), platelet-to-lymphocyte ratios (PLR), C-reactive protein-to-albumin ratios (CAR), and systemic immune inflammation indices (SII) were calculated at the time of hospital admission and after three weeks.
Results: The mean age of the participants was 39.0±13.1 years and the majority were male (n: 75). Reductions were observed in all inflammatory markers after three weeks. The CRP decreased from a median value of 2.6 (interquartile range (IQR): 1.1-5.3) to 1.90 (IQR: 0.85-3.30) (p=0.001, effect size=0.375). The CAR changed from 0.064 (IQR: 0.026-0.115) to 0.043 (IQR: 0.017-0.077) (p=0.005, effect size=0.371). The NLR demonstrated a significant reduction from 2.31 (IQR: 1.73-3.24) to 1.73 (IQR: 1.28-2.27) (p<0.001, effect size=0.647). The SII decreased from 634 (IQR: 425-870) to 470 (IQR: 321-645) (p<0.001, effect size=0.577). The PLR went down from 9.85 (IQR: 7.4-12.7) to 8.21 (IQR: 6.22-10.3) (p<0.001, effect size=0.547). Lastly, the MLR reduced from 0.297 (IQR: 0.221-0.378) to 0.258 (IQR: 0.195-0.319) (p<0.001, effect size=0.522).
Conclusion: This study underscores the influence of regular antipsychotic treatment and hospital care in reducing inflammation markers like NLR, MLR, PLR, SII, and CAR in schizophrenia patients. Future studies should explore the potential of markers like CAR and SII in detecting low-grade inflammation, and further probe into the role of sleep, nutrition, and physical activity, emphasising the paramount role of comprehensive hospital care. |
| format | Article |
| id | doaj-art-468d2e5e12ba4efc84995c5af8e5d2a2 |
| institution | Kabale University |
| issn | 2602-3741 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Genel Tıp Dergisi |
| spelling | doaj-art-468d2e5e12ba4efc84995c5af8e5d2a22025-01-03T01:05:27ZengSelcuk University PressGenel Tıp Dergisi2602-37412023-12-0133676376710.54005/geneltip.1328023154Longitudinal Assessment of Alterations in Peripheral Inflammatory Markers Over a Hospitalization Period in Patients with SchizophreniaSüleyman Dönmezler0Oya Güçlü1İmren Kurt2Halil Ibrahim Ozturk3SANKO Üniversitesi Tıp FakültesiBaşakşehir Çam ve Sakura Şehir HastanesiBaşakşehir Çam ve Sakura Şehir HastanesiSANKO ÜNİVERSİTESİ, TIP FAKÜLTESİObjective: To assess the effects of regular medication administration, diet, sleep, and physical activity provided by hospital care on inflammatory markers in schizophrenia patients. The primary hypothesis of our study is that the assembly of various factors, will reduce low-grade inflammation in a short period. Materials and Methods: This retrospective longitudinal study involved 106 patients diagnosed with schizophrenia who met the exclusion and inclusion criteria. Inflammatory markers such as neutrophil-to-lymphocyte Ratios (NLR), monocyte-to-lymphocyte ratios (MLR), platelet-to-lymphocyte ratios (PLR), C-reactive protein-to-albumin ratios (CAR), and systemic immune inflammation indices (SII) were calculated at the time of hospital admission and after three weeks. Results: The mean age of the participants was 39.0±13.1 years and the majority were male (n: 75). Reductions were observed in all inflammatory markers after three weeks. The CRP decreased from a median value of 2.6 (interquartile range (IQR): 1.1-5.3) to 1.90 (IQR: 0.85-3.30) (p=0.001, effect size=0.375). The CAR changed from 0.064 (IQR: 0.026-0.115) to 0.043 (IQR: 0.017-0.077) (p=0.005, effect size=0.371). The NLR demonstrated a significant reduction from 2.31 (IQR: 1.73-3.24) to 1.73 (IQR: 1.28-2.27) (p<0.001, effect size=0.647). The SII decreased from 634 (IQR: 425-870) to 470 (IQR: 321-645) (p<0.001, effect size=0.577). The PLR went down from 9.85 (IQR: 7.4-12.7) to 8.21 (IQR: 6.22-10.3) (p<0.001, effect size=0.547). Lastly, the MLR reduced from 0.297 (IQR: 0.221-0.378) to 0.258 (IQR: 0.195-0.319) (p<0.001, effect size=0.522). Conclusion: This study underscores the influence of regular antipsychotic treatment and hospital care in reducing inflammation markers like NLR, MLR, PLR, SII, and CAR in schizophrenia patients. Future studies should explore the potential of markers like CAR and SII in detecting low-grade inflammation, and further probe into the role of sleep, nutrition, and physical activity, emphasising the paramount role of comprehensive hospital care.https://dergipark.org.tr/tr/download/article-file/3266746schizophrenialow-grade inflammationantipsychoticssystemic immune inflamattion index (sii)c-reaktive protein (crp)- to-albumin ratio (car)şizofrenidüşük dereceli inflamasyonantipsikotiklersistemik immün inflamasyon indeksic-reaktif protein (crp) albumin oranı (car) |
| spellingShingle | Süleyman Dönmezler Oya Güçlü İmren Kurt Halil Ibrahim Ozturk Longitudinal Assessment of Alterations in Peripheral Inflammatory Markers Over a Hospitalization Period in Patients with Schizophrenia Genel Tıp Dergisi schizophrenia low-grade inflammation antipsychotics systemic immune inflamattion index (sii) c-reaktive protein (crp)- to-albumin ratio (car) şizofreni düşük dereceli inflamasyon antipsikotikler sistemik immün inflamasyon indeksi c-reaktif protein (crp) albumin oranı (car) |
| title | Longitudinal Assessment of Alterations in Peripheral Inflammatory Markers Over a Hospitalization Period in Patients with Schizophrenia |
| title_full | Longitudinal Assessment of Alterations in Peripheral Inflammatory Markers Over a Hospitalization Period in Patients with Schizophrenia |
| title_fullStr | Longitudinal Assessment of Alterations in Peripheral Inflammatory Markers Over a Hospitalization Period in Patients with Schizophrenia |
| title_full_unstemmed | Longitudinal Assessment of Alterations in Peripheral Inflammatory Markers Over a Hospitalization Period in Patients with Schizophrenia |
| title_short | Longitudinal Assessment of Alterations in Peripheral Inflammatory Markers Over a Hospitalization Period in Patients with Schizophrenia |
| title_sort | longitudinal assessment of alterations in peripheral inflammatory markers over a hospitalization period in patients with schizophrenia |
| topic | schizophrenia low-grade inflammation antipsychotics systemic immune inflamattion index (sii) c-reaktive protein (crp)- to-albumin ratio (car) şizofreni düşük dereceli inflamasyon antipsikotikler sistemik immün inflamasyon indeksi c-reaktif protein (crp) albumin oranı (car) |
| url | https://dergipark.org.tr/tr/download/article-file/3266746 |
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