Selenium and thyroid dysfunction: from pathophysiology to treatment options
The review focuses on the discussion of the role of selenium in the thyroid hormone metabolism and its impact on the risk of thyroid disorders, among which the most common are autoimmune thyroiditis (Hashimoto's disease) and Graves' disease. Selenium, which is a component of selenoproteins...
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LLC "MEDIAFORMAT"
2024-09-01
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| Series: | Клинический разбор в общей медицине |
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| Online Access: | https://klin-razbor.ru/en/archive/2024/vol-5-9-2024/selenium-and-thyroid-dysfunction-from-pathophysiology-to-treatment-options_6964/?element |
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| author | Ekaterina N. Dudinskaya |
| author_facet | Ekaterina N. Dudinskaya |
| author_sort | Ekaterina N. Dudinskaya |
| collection | DOAJ |
| description | The review focuses on the discussion of the role of selenium in the thyroid hormone metabolism and its impact on the risk of thyroid disorders, among which the most common are autoimmune thyroiditis (Hashimoto's disease) and Graves' disease. Selenium, which is a component of selenoproteins, such as glutathione peroxidase and iodothyronine deiodinases, is involved in the thyroid hormone synthesis and regulation and has an antioxidant effect on thyrocytes. Selenium deficiency can contribute to the development of thyroid disorders, aggravating the inflammatory processes and increasing the levels of antibodies against thyroid peroxidase (TPO AB) and thyroglobulin (TG AB).
Clinical trials show that selenium supplements can reduce the levels of thyroid autoantibodies in patients with autoimmune thyroiditis, thereby improving the thyroid structure and reducing inflammation. In patients with Graves' disease, selenium supplements demonstrate a positive effect on the ophthalmopathy progression and quality of life. However, the effect of selenium varies depending on the mineral baseline levels, which emphasizes the need for individual approach to treatment. The literature review shows an important role of selenium in maintaining health of the thyroid gland and emphasizes the need for further research aimed to optimize therapy based on the selenium supplementation. |
| format | Article |
| id | doaj-art-46756a87886743f785643bb45e6c4be4 |
| institution | Kabale University |
| issn | 2713-2552 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | LLC "MEDIAFORMAT" |
| record_format | Article |
| series | Клинический разбор в общей медицине |
| spelling | doaj-art-46756a87886743f785643bb45e6c4be42024-11-26T11:12:27ZengLLC "MEDIAFORMAT"Клинический разбор в общей медицине2713-25522024-09-0159919810.47407/kr2024.5.9.00486Selenium and thyroid dysfunction: from pathophysiology to treatment optionsEkaterina N. Dudinskaya 0Pirogov Russian National Research Medical University, Moscow, RussiaThe review focuses on the discussion of the role of selenium in the thyroid hormone metabolism and its impact on the risk of thyroid disorders, among which the most common are autoimmune thyroiditis (Hashimoto's disease) and Graves' disease. Selenium, which is a component of selenoproteins, such as glutathione peroxidase and iodothyronine deiodinases, is involved in the thyroid hormone synthesis and regulation and has an antioxidant effect on thyrocytes. Selenium deficiency can contribute to the development of thyroid disorders, aggravating the inflammatory processes and increasing the levels of antibodies against thyroid peroxidase (TPO AB) and thyroglobulin (TG AB). Clinical trials show that selenium supplements can reduce the levels of thyroid autoantibodies in patients with autoimmune thyroiditis, thereby improving the thyroid structure and reducing inflammation. In patients with Graves' disease, selenium supplements demonstrate a positive effect on the ophthalmopathy progression and quality of life. However, the effect of selenium varies depending on the mineral baseline levels, which emphasizes the need for individual approach to treatment. The literature review shows an important role of selenium in maintaining health of the thyroid gland and emphasizes the need for further research aimed to optimize therapy based on the selenium supplementation.https://klin-razbor.ru/en/archive/2024/vol-5-9-2024/selenium-and-thyroid-dysfunction-from-pathophysiology-to-treatment-options_6964/?elementthyroid hormonesthyrotoxicosisautoimmune thyroiditisseleniumantioxidants |
| spellingShingle | Ekaterina N. Dudinskaya Selenium and thyroid dysfunction: from pathophysiology to treatment options Клинический разбор в общей медицине thyroid hormones thyrotoxicosis autoimmune thyroiditis selenium antioxidants |
| title | Selenium and thyroid dysfunction: from pathophysiology to treatment options |
| title_full | Selenium and thyroid dysfunction: from pathophysiology to treatment options |
| title_fullStr | Selenium and thyroid dysfunction: from pathophysiology to treatment options |
| title_full_unstemmed | Selenium and thyroid dysfunction: from pathophysiology to treatment options |
| title_short | Selenium and thyroid dysfunction: from pathophysiology to treatment options |
| title_sort | selenium and thyroid dysfunction from pathophysiology to treatment options |
| topic | thyroid hormones thyrotoxicosis autoimmune thyroiditis selenium antioxidants |
| url | https://klin-razbor.ru/en/archive/2024/vol-5-9-2024/selenium-and-thyroid-dysfunction-from-pathophysiology-to-treatment-options_6964/?element |
| work_keys_str_mv | AT ekaterinandudinskaya seleniumandthyroiddysfunctionfrompathophysiologytotreatmentoptions |