Metabolomic Signatures Influenced by Different Cardioplegic Solutions in Cardiac Surgery
Introduction: Cardioplegia is crucial for myocardial protection during cardiac surgery. However, the impact of different cardioplegia formulations on patients’ metabolomic responses has not been explored. The objective is to identify unique metabolomic signatures associated with each cardioplegia ty...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of the Practice of Cardiovascular Sciences |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jpcs.jpcs_72_24 |
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| author | Chananya Karunasumetta Chotika Chatgasem Suriya Punchai Kittisak Sawanyawisuth |
| author_facet | Chananya Karunasumetta Chotika Chatgasem Suriya Punchai Kittisak Sawanyawisuth |
| author_sort | Chananya Karunasumetta |
| collection | DOAJ |
| description | Introduction:
Cardioplegia is crucial for myocardial protection during cardiac surgery. However, the impact of different cardioplegia formulations on patients’ metabolomic responses has not been explored. The objective is to identify unique metabolomic signatures associated with each cardioplegia type and evaluate their potential correlations with clinical outcomes.
Methods:
A prospective cohort study was conducted from January 2023 to June 2024, involving 105 samples from 21 patients undergoing isolated coronary artery bypass graft with modified del Nido, Custodiol®, or St. Thomas cardioplegia. Pre- and postoperative plasma samples were collected for analysis of cardiac enzyme levels and proton nuclear magnetic resonance metabolomic profiling.
Results:
No significant differences in clinical outcomes or cardiac enzyme levels were observed between the groups. However, distinct pre-and postoperative metabolomic profiles were identified. The Custodiol group exhibited significant postoperative metabolomic changes within the first 2 days, with nine differentially expressed metabolites (DEMs). In contrast, modified del Nido cardioplegia affected three DEMs on postoperative day 0, whereas St. Thomas showed no alteration in the postoperative metabolomic profile. These DEMs were associated with protein and energy production, oxidative stress, and inflammatory responses. Key differential metabolites between the groups included histidine and alanine, which notably impacted the histidine metabolism pathway.
Conclusion:
The findings demonstrate that distinct cardioplegia solutions result in differential postoperative metabolomic alterations, with Custodiol exhibiting the most pronounced shifts, whereas St. Thomas cardioplegia showed no significant postoperative metabolic changes. |
| format | Article |
| id | doaj-art-461d65eb0bd042a98f0f413d604c4199 |
| institution | Kabale University |
| issn | 2395-5414 2454-2830 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of the Practice of Cardiovascular Sciences |
| spelling | doaj-art-461d65eb0bd042a98f0f413d604c41992025-01-14T05:55:20ZengWolters Kluwer Medknow PublicationsJournal of the Practice of Cardiovascular Sciences2395-54142454-28302024-12-0110316517410.4103/jpcs.jpcs_72_24Metabolomic Signatures Influenced by Different Cardioplegic Solutions in Cardiac SurgeryChananya KarunasumettaChotika ChatgasemSuriya PunchaiKittisak SawanyawisuthIntroduction: Cardioplegia is crucial for myocardial protection during cardiac surgery. However, the impact of different cardioplegia formulations on patients’ metabolomic responses has not been explored. The objective is to identify unique metabolomic signatures associated with each cardioplegia type and evaluate their potential correlations with clinical outcomes. Methods: A prospective cohort study was conducted from January 2023 to June 2024, involving 105 samples from 21 patients undergoing isolated coronary artery bypass graft with modified del Nido, Custodiol®, or St. Thomas cardioplegia. Pre- and postoperative plasma samples were collected for analysis of cardiac enzyme levels and proton nuclear magnetic resonance metabolomic profiling. Results: No significant differences in clinical outcomes or cardiac enzyme levels were observed between the groups. However, distinct pre-and postoperative metabolomic profiles were identified. The Custodiol group exhibited significant postoperative metabolomic changes within the first 2 days, with nine differentially expressed metabolites (DEMs). In contrast, modified del Nido cardioplegia affected three DEMs on postoperative day 0, whereas St. Thomas showed no alteration in the postoperative metabolomic profile. These DEMs were associated with protein and energy production, oxidative stress, and inflammatory responses. Key differential metabolites between the groups included histidine and alanine, which notably impacted the histidine metabolism pathway. Conclusion: The findings demonstrate that distinct cardioplegia solutions result in differential postoperative metabolomic alterations, with Custodiol exhibiting the most pronounced shifts, whereas St. Thomas cardioplegia showed no significant postoperative metabolic changes.https://journals.lww.com/10.4103/jpcs.jpcs_72_24coronary artery bypass graftcardioplegiadifferentially expressed metabolitesmetabolomics profiles |
| spellingShingle | Chananya Karunasumetta Chotika Chatgasem Suriya Punchai Kittisak Sawanyawisuth Metabolomic Signatures Influenced by Different Cardioplegic Solutions in Cardiac Surgery Journal of the Practice of Cardiovascular Sciences coronary artery bypass graft cardioplegia differentially expressed metabolites metabolomics profiles |
| title | Metabolomic Signatures Influenced by Different Cardioplegic Solutions in Cardiac Surgery |
| title_full | Metabolomic Signatures Influenced by Different Cardioplegic Solutions in Cardiac Surgery |
| title_fullStr | Metabolomic Signatures Influenced by Different Cardioplegic Solutions in Cardiac Surgery |
| title_full_unstemmed | Metabolomic Signatures Influenced by Different Cardioplegic Solutions in Cardiac Surgery |
| title_short | Metabolomic Signatures Influenced by Different Cardioplegic Solutions in Cardiac Surgery |
| title_sort | metabolomic signatures influenced by different cardioplegic solutions in cardiac surgery |
| topic | coronary artery bypass graft cardioplegia differentially expressed metabolites metabolomics profiles |
| url | https://journals.lww.com/10.4103/jpcs.jpcs_72_24 |
| work_keys_str_mv | AT chananyakarunasumetta metabolomicsignaturesinfluencedbydifferentcardioplegicsolutionsincardiacsurgery AT chotikachatgasem metabolomicsignaturesinfluencedbydifferentcardioplegicsolutionsincardiacsurgery AT suriyapunchai metabolomicsignaturesinfluencedbydifferentcardioplegicsolutionsincardiacsurgery AT kittisaksawanyawisuth metabolomicsignaturesinfluencedbydifferentcardioplegicsolutionsincardiacsurgery |