Perspectives on the use of decellularized/devitalized and lyophilized human perinatal tissues for bone repair: Advantages and remaining challenges
Human amniotic membrane (hAM) has been extensively used for several decades as a bioactive scaffold for regenerative medicine. In its cryopreserved form—one of the main storage formats—the presence of viable cells has often been questioned. Furthermore, there is little published evidence of the role...
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Elsevier
2025-02-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006424004253 |
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| author | Lauriana Solecki Mathilde Fenelon Halima Kerdjoudj Roberta Di Pietro Gianmarco Stati Camille Gaudet Eugenie Bertin Jeremie Nallet Aurélien Louvrier Thomas Gualdi Jessica Schiavi-Tritz Florelle Gindraux |
| author_facet | Lauriana Solecki Mathilde Fenelon Halima Kerdjoudj Roberta Di Pietro Gianmarco Stati Camille Gaudet Eugenie Bertin Jeremie Nallet Aurélien Louvrier Thomas Gualdi Jessica Schiavi-Tritz Florelle Gindraux |
| author_sort | Lauriana Solecki |
| collection | DOAJ |
| description | Human amniotic membrane (hAM) has been extensively used for several decades as a bioactive scaffold for regenerative medicine. In its cryopreserved form—one of the main storage formats—the presence of viable cells has often been questioned. Furthermore, there is little published evidence of the role of endogenous amniotic cells from cryopreserved hAM in tissue repair.Some technologies, often patented and combined, have facilitated the use of hAM. Decellularization and devitalization processes have been developed to ensure its safety and prevent immune rejection. Lyophilization and dehydration methods have had a significant impact on clinical practices by enabling storage at room temperature in the operating room and making handling and cutting easier. Consequently, the commercialization of hAM has expanded, initially in the USA, and now in Europe.In the last decade, there has been growing interest in new perinatal tissues in clinical medicine. Similar processes have been adapted for these tissues to prevent immune or inflammatory reactions, and to improve storage and make them easier to use. For example, in the USA, many products marketed for wound healing undergo lyophilization, sometimes in combination with decellularization.Given our expertise, we wanted to highlight the potential of decellularized/devitalized and lyophilized perinatal tissues in regenerative medicine, particularly for bone repair. In this opinion paper, we discuss why these tissues represent the future of regenerative medicine, their potential drawbacks and strategies to overcome these challenges. |
| format | Article |
| id | doaj-art-45f1c467c13f4b519e4c33310a8d3fc1 |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-45f1c467c13f4b519e4c33310a8d3fc12025-01-17T04:52:00ZengElsevierMaterials Today Bio2590-00642025-02-0130101364Perspectives on the use of decellularized/devitalized and lyophilized human perinatal tissues for bone repair: Advantages and remaining challengesLauriana Solecki0Mathilde Fenelon1Halima Kerdjoudj2Roberta Di Pietro3Gianmarco Stati4Camille Gaudet5Eugenie Bertin6Jeremie Nallet7Aurélien Louvrier8Thomas Gualdi9Jessica Schiavi-Tritz10Florelle Gindraux11CHU Besançon, Service d'Ophtalmologie, F-25000 Besançon, France; Université de Franche-Comté, Laboratoire SINERGIES, F-25000 Besançon, France; Hôpitaux Universitaires de Strasbourg, Service d'Ophtalmologie, F-67091 Strasbourg, FranceUniversité de Bordeaux, INSERM, BIOTIS, U1026, F-33000 Bordeaux, France; Service de Chirurgie Orale, CHU Bordeaux, F-33076 Bordeaux, FranceUniversité de Reims Champagne Ardenne, Biomatériaux et Inflammation en Site Osseux (BIOS) EA 4691, F-51100 Reims, France; Université de Reims Champagne Ardenne, Faculté Dentaire, F-51100 Reims, FranceDepartment of Medicine and Aging Sciences, G. d’Annunzio University of Chieti-Pescara, Chieti, Italy; StemTeCh Group, Fondazione G. d’Annunzio, University of Chieti- Pescara, Chieti, ItalyDepartment of Medicine and Aging Sciences, G. d’Annunzio University of Chieti-Pescara, Chieti, Italy; StemTeCh Group, Fondazione G. d’Annunzio, University of Chieti- Pescara, Chieti, ItalyCHU Besançon, Service de chirurgie Maxillo-faciale, Stomatologie et Odontologie Hospitalière, F-25000 Besançon, FranceCHU Besançon, Service de chirurgie Maxillo-faciale, Stomatologie et Odontologie Hospitalière, F-25000 Besançon, FranceCHU Besançon, Service de chirurgie Pédiatrique, F-25000 Besançon, FranceUniversité de Franche-Comté, Laboratoire SINERGIES, F-25000 Besançon, France; CHU Besançon, Service de chirurgie Maxillo-faciale, Stomatologie et Odontologie Hospitalière, F-25000 Besançon, FranceCHU Besancon, Centre d’Investigation Clinique–Inserm CIC 1431, F 25000 Besançon, FranceUniversity of Lorraine, CNRS, LRGP, F-54000 Nancy, FranceUniversité de Franche-Comté, Laboratoire SINERGIES, F-25000 Besançon, France; CHU Besançon, Service de chirurgie Maxillo-faciale, Stomatologie et Odontologie Hospitalière, F-25000 Besançon, France; Corresponding author. CHU Besançon, Service de chirurgie Maxillo-faciale, Stomatologie et Odontologie Hospitalière, F-25000 Besançon, France.Human amniotic membrane (hAM) has been extensively used for several decades as a bioactive scaffold for regenerative medicine. In its cryopreserved form—one of the main storage formats—the presence of viable cells has often been questioned. Furthermore, there is little published evidence of the role of endogenous amniotic cells from cryopreserved hAM in tissue repair.Some technologies, often patented and combined, have facilitated the use of hAM. Decellularization and devitalization processes have been developed to ensure its safety and prevent immune rejection. Lyophilization and dehydration methods have had a significant impact on clinical practices by enabling storage at room temperature in the operating room and making handling and cutting easier. Consequently, the commercialization of hAM has expanded, initially in the USA, and now in Europe.In the last decade, there has been growing interest in new perinatal tissues in clinical medicine. Similar processes have been adapted for these tissues to prevent immune or inflammatory reactions, and to improve storage and make them easier to use. For example, in the USA, many products marketed for wound healing undergo lyophilization, sometimes in combination with decellularization.Given our expertise, we wanted to highlight the potential of decellularized/devitalized and lyophilized perinatal tissues in regenerative medicine, particularly for bone repair. In this opinion paper, we discuss why these tissues represent the future of regenerative medicine, their potential drawbacks and strategies to overcome these challenges.http://www.sciencedirect.com/science/article/pii/S2590006424004253Perinatal derivativesAmniotic membraneChorionWharton's jellyUmbilical cordMedical device |
| spellingShingle | Lauriana Solecki Mathilde Fenelon Halima Kerdjoudj Roberta Di Pietro Gianmarco Stati Camille Gaudet Eugenie Bertin Jeremie Nallet Aurélien Louvrier Thomas Gualdi Jessica Schiavi-Tritz Florelle Gindraux Perspectives on the use of decellularized/devitalized and lyophilized human perinatal tissues for bone repair: Advantages and remaining challenges Materials Today Bio Perinatal derivatives Amniotic membrane Chorion Wharton's jelly Umbilical cord Medical device |
| title | Perspectives on the use of decellularized/devitalized and lyophilized human perinatal tissues for bone repair: Advantages and remaining challenges |
| title_full | Perspectives on the use of decellularized/devitalized and lyophilized human perinatal tissues for bone repair: Advantages and remaining challenges |
| title_fullStr | Perspectives on the use of decellularized/devitalized and lyophilized human perinatal tissues for bone repair: Advantages and remaining challenges |
| title_full_unstemmed | Perspectives on the use of decellularized/devitalized and lyophilized human perinatal tissues for bone repair: Advantages and remaining challenges |
| title_short | Perspectives on the use of decellularized/devitalized and lyophilized human perinatal tissues for bone repair: Advantages and remaining challenges |
| title_sort | perspectives on the use of decellularized devitalized and lyophilized human perinatal tissues for bone repair advantages and remaining challenges |
| topic | Perinatal derivatives Amniotic membrane Chorion Wharton's jelly Umbilical cord Medical device |
| url | http://www.sciencedirect.com/science/article/pii/S2590006424004253 |
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