Advances in 3D printing combined with tissue engineering for nerve regeneration and repair
Abstract The repair of nerve damage has long posed a challenge owing to limited self-repair capacity and the highly differentiated nature of nerves. While new therapeutic and pharmacologic interventions have emerged in neurology, their regenerative efficacy remains limited. Tissue engineering offers...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-024-03052-9 |
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| author | Weifang Liao Yuying Shi Zuguang Li Xiaoping Yin |
| author_facet | Weifang Liao Yuying Shi Zuguang Li Xiaoping Yin |
| author_sort | Weifang Liao |
| collection | DOAJ |
| description | Abstract The repair of nerve damage has long posed a challenge owing to limited self-repair capacity and the highly differentiated nature of nerves. While new therapeutic and pharmacologic interventions have emerged in neurology, their regenerative efficacy remains limited. Tissue engineering offers a promising avenue for overcoming the limitations of conventional treatments and increasing the outcomes of regenerative repair. By implanting scaffolds into damaged nerve tissue sites, the repair and functional reconstruction of nerve injuries can be significantly facilitated. The integration of three-dimensional (3D) printing technology introduces a novel approach for accurate simulation and scalably fabricating neural tissue structures. Tissue-engineered scaffolds developed through 3D printing technology are expected to be a viable therapeutic option for nerve injuries, with broad applicability and continued development. This review systematically examines recent advances in 3D printing and tissue engineering for nerve regeneration and repair. It details the basic principles and construction strategies of neural tissue engineering and explores the crucial role of 3D printing technology. Additionally, it elucidates specific applications and technical challenges associated with this integrated approach, thereby providing valuable insights into innovative strategies and pragmatic implementation within this field. Graphical Abstract |
| format | Article |
| id | doaj-art-45dadd0ab6d346fb8776b39ab944bc0c |
| institution | Kabale University |
| issn | 1477-3155 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-45dadd0ab6d346fb8776b39ab944bc0c2025-01-05T12:45:00ZengBMCJournal of Nanobiotechnology1477-31552025-01-0123112910.1186/s12951-024-03052-9Advances in 3D printing combined with tissue engineering for nerve regeneration and repairWeifang Liao0Yuying Shi1Zuguang Li2Xiaoping Yin3Department of Medical Laboratory, Affiliated Hospital of Jiujiang UniversityDepartment of Medical Laboratory, Affiliated Hospital of Jiujiang UniversityDepartment of Pathophysiology, Key Lab of Neurological Disorder of Education Ministry, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Neurology, Affiliated Hospital of Jiujiang UniversityAbstract The repair of nerve damage has long posed a challenge owing to limited self-repair capacity and the highly differentiated nature of nerves. While new therapeutic and pharmacologic interventions have emerged in neurology, their regenerative efficacy remains limited. Tissue engineering offers a promising avenue for overcoming the limitations of conventional treatments and increasing the outcomes of regenerative repair. By implanting scaffolds into damaged nerve tissue sites, the repair and functional reconstruction of nerve injuries can be significantly facilitated. The integration of three-dimensional (3D) printing technology introduces a novel approach for accurate simulation and scalably fabricating neural tissue structures. Tissue-engineered scaffolds developed through 3D printing technology are expected to be a viable therapeutic option for nerve injuries, with broad applicability and continued development. This review systematically examines recent advances in 3D printing and tissue engineering for nerve regeneration and repair. It details the basic principles and construction strategies of neural tissue engineering and explores the crucial role of 3D printing technology. Additionally, it elucidates specific applications and technical challenges associated with this integrated approach, thereby providing valuable insights into innovative strategies and pragmatic implementation within this field. Graphical Abstracthttps://doi.org/10.1186/s12951-024-03052-93D printingNerve regenerationNerve repairTissue engineering |
| spellingShingle | Weifang Liao Yuying Shi Zuguang Li Xiaoping Yin Advances in 3D printing combined with tissue engineering for nerve regeneration and repair Journal of Nanobiotechnology 3D printing Nerve regeneration Nerve repair Tissue engineering |
| title | Advances in 3D printing combined with tissue engineering for nerve regeneration and repair |
| title_full | Advances in 3D printing combined with tissue engineering for nerve regeneration and repair |
| title_fullStr | Advances in 3D printing combined with tissue engineering for nerve regeneration and repair |
| title_full_unstemmed | Advances in 3D printing combined with tissue engineering for nerve regeneration and repair |
| title_short | Advances in 3D printing combined with tissue engineering for nerve regeneration and repair |
| title_sort | advances in 3d printing combined with tissue engineering for nerve regeneration and repair |
| topic | 3D printing Nerve regeneration Nerve repair Tissue engineering |
| url | https://doi.org/10.1186/s12951-024-03052-9 |
| work_keys_str_mv | AT weifangliao advancesin3dprintingcombinedwithtissueengineeringfornerveregenerationandrepair AT yuyingshi advancesin3dprintingcombinedwithtissueengineeringfornerveregenerationandrepair AT zuguangli advancesin3dprintingcombinedwithtissueengineeringfornerveregenerationandrepair AT xiaopingyin advancesin3dprintingcombinedwithtissueengineeringfornerveregenerationandrepair |