Structural insights into the mechanisms of urea permeation and distinct inhibition modes of urea transporters

Structural insights into the mechanisms of urea permeation and distinct inhibition modes of urea transporters

Abstract Urea’s transmembrane transport through urea transporters (UT) is a fundamental physiological behavior for life activities. Here, we present 11 cryo-EM structures of four UT members in resting states, urea transport states, or inactive states bound with synthetic competitive, uncompetitive o...

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Main Authors: Shen-Ming Huang, Zhi-Zhen Huang, Lei Liu, Meng-Yao Xiong, Chao Zhang, Bo-Yang Cai, Ming-Wei Wang, Kui Cai, Ying-Li Jia, Jia-Le Wang, Ming-Hui Zhang, Yi-He Xie, Min Li, Hang Zhang, Cheng-Hao Weng, Xin Wen, Zhi Li, Ying Sun, Fan Yi, Zhao Yang, Peng Xiao, Fan Yang, Xiao Yu, Lu Tie, Bao-Xue Yang, Jin-Peng Sun
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54305-y
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https://doi.org/10.1038/s41467-024-54305-y

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