Ocular changes after simultaneous kidney-pancreas transplant
<p> <b>I.V. Vorobyeva<sup>1</sup>, E.V. Bulava<sup>1</sup>, L.K. Moshetova<sup>1</sup>, A.V. Pinchuk<sup>2–4</sup></b> </p> <p> <b><sup>1</sup>Russian Medical Academy of Continuous Professional Educatio...
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2022-05-01
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| Series: | РМЖ "Клиническая офтальмология" |
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| author | I.V. Vorobyeva Е.V. Bulava L.K. Moshetova A.V. Pinchuk |
| author_facet | I.V. Vorobyeva Е.V. Bulava L.K. Moshetova A.V. Pinchuk |
| author_sort | I.V. Vorobyeva |
| collection | DOAJ |
| description | <p>
<b>I.V. Vorobyeva<sup>1</sup>, E.V. Bulava<sup>1</sup>, L.K. Moshetova<sup>1</sup>, A.V. Pinchuk<sup>2–4</sup></b>
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<b><sup>1</sup>Russian Medical Academy of Continuous Professional Education, Moscow, </b>
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<b> </b><b>Russian Federation</b>
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<b><sup>2</sup>N.V. Sklifosovskiy Research Institute for Emergency Medical Aid, Moscow, Russian Federation</b>
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<b><sup>3</sup>A.I. Yevdokimov Moscow University of Medicine & Dentistry, Moscow, Russian Federation</b>
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<b><sup>4</sup>Research Institute of Public Health Organization and Medical Management, Moscow, </b> <b>Russian Federation</b>
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<i>Type 1 diabetes (T1D) is one of the most common chronic diseases in young individuals. Diabetic nephropathy, being one of the most dangerous complications of T1D, progresses to end-stage renal disease within 10–15 years in 80%. The simultaneous kidney-pancreas transplant prevents insulin therapy and dialysis, thereby avoiding further progression of complications of diabetes. Normalization of carbohydrate metabolism and resolving of uremia after simultaneous kidney-pancreas transplant are beneficial for ocular structures. This article reviews studies on the pattern of changes in ocular structures in the post-transplant period. The procedure improves peripheral microcirculation of the bulbar conjunctiva and corneal innervation. Most studies demonstrate stabilization and improvement of the course of diabetic retinopathy as illustrated by the reduction in active vascular proliferation, need for retinal laser photocoagulation and vitrectomy. Meanwhile, some studi es failed to reveal any differences in the morphological functional status of the retina in the pre- and postoperative periods. An increase in cataract rate among simultaneous kidney-pancreas transplant recipients receiving immunosuppressant therapy remains a challenge.</i>
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<i><b>Keywords</b>: type 1 diabetes, kidney transplant, pancreas transplant, simultaneous kidney-pancreas transplant, diabetic retinopathy, diabetic macular edema.</i>
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<i><b>For citation: </b>Vorobyeva I.V., Bulava E.V., Moshetova L.K., Pinchuk A.V. Ocular changes after simultaneous kidney-pancreas transplant. Russian Journal of Clinical Ophthalmology. 2022;22(2):132–136 (in Russ.). DOI: 10.32364/2311-7729-2022-22-2-132-136.</i>
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| format | Article |
| id | doaj-art-4589f58274064eb9a79f0953066538ae |
| institution | Kabale University |
| issn | 2311-7729 2619-1571 |
| language | Russian |
| publishDate | 2022-05-01 |
| publisher | Prime-Media |
| record_format | Article |
| series | РМЖ "Клиническая офтальмология" |
| spelling | doaj-art-4589f58274064eb9a79f0953066538ae2025-01-16T09:39:38ZrusPrime-MediaРМЖ "Клиническая офтальмология"2311-77292619-15712022-05-0122231458Ocular changes after simultaneous kidney-pancreas transplantI.V. Vorobyeva0Е.V. Bulava1L.K. Moshetova2A.V. Pinchuk3Russian Journal of Clinical Ophthalmology, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Clinical Ophthalmology, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Clinical Ophthalmology, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Clinical Ophthalmology, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399<p> <b>I.V. Vorobyeva<sup>1</sup>, E.V. Bulava<sup>1</sup>, L.K. Moshetova<sup>1</sup>, A.V. Pinchuk<sup>2–4</sup></b> </p> <p> <b><sup>1</sup>Russian Medical Academy of Continuous Professional Education, Moscow, </b> </p> <p> <b> </b><b>Russian Federation</b> </p> <p> <b><sup>2</sup>N.V. Sklifosovskiy Research Institute for Emergency Medical Aid, Moscow, Russian Federation</b> </p> <p> <b><sup>3</sup>A.I. Yevdokimov Moscow University of Medicine & Dentistry, Moscow, Russian Federation</b> </p> <p> <b><sup>4</sup>Research Institute of Public Health Organization and Medical Management, Moscow, </b> <b>Russian Federation</b> </p> <p> <i>Type 1 diabetes (T1D) is one of the most common chronic diseases in young individuals. Diabetic nephropathy, being one of the most dangerous complications of T1D, progresses to end-stage renal disease within 10–15 years in 80%. The simultaneous kidney-pancreas transplant prevents insulin therapy and dialysis, thereby avoiding further progression of complications of diabetes. Normalization of carbohydrate metabolism and resolving of uremia after simultaneous kidney-pancreas transplant are beneficial for ocular structures. This article reviews studies on the pattern of changes in ocular structures in the post-transplant period. The procedure improves peripheral microcirculation of the bulbar conjunctiva and corneal innervation. Most studies demonstrate stabilization and improvement of the course of diabetic retinopathy as illustrated by the reduction in active vascular proliferation, need for retinal laser photocoagulation and vitrectomy. Meanwhile, some studi es failed to reveal any differences in the morphological functional status of the retina in the pre- and postoperative periods. An increase in cataract rate among simultaneous kidney-pancreas transplant recipients receiving immunosuppressant therapy remains a challenge.</i> </p> <p> <i><b>Keywords</b>: type 1 diabetes, kidney transplant, pancreas transplant, simultaneous kidney-pancreas transplant, diabetic retinopathy, diabetic macular edema.</i> </p> <p> <i><b>For citation: </b>Vorobyeva I.V., Bulava E.V., Moshetova L.K., Pinchuk A.V. Ocular changes after simultaneous kidney-pancreas transplant. Russian Journal of Clinical Ophthalmology. 2022;22(2):132–136 (in Russ.). DOI: 10.32364/2311-7729-2022-22-2-132-136.</i> </p>http://clinopht.com/upload/iblock/d25/d25124f600399c8f3f4831bcc442094b.pdf |
| spellingShingle | I.V. Vorobyeva Е.V. Bulava L.K. Moshetova A.V. Pinchuk Ocular changes after simultaneous kidney-pancreas transplant РМЖ "Клиническая офтальмология" |
| title | Ocular changes after simultaneous kidney-pancreas transplant |
| title_full | Ocular changes after simultaneous kidney-pancreas transplant |
| title_fullStr | Ocular changes after simultaneous kidney-pancreas transplant |
| title_full_unstemmed | Ocular changes after simultaneous kidney-pancreas transplant |
| title_short | Ocular changes after simultaneous kidney-pancreas transplant |
| title_sort | ocular changes after simultaneous kidney pancreas transplant |
| url | http://clinopht.com/upload/iblock/d25/d25124f600399c8f3f4831bcc442094b.pdf |
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