Anti-inflammatory effect of Angiotensin 1-7 in white adipose tissue
Obesity is a global health concern that promotes chronic low-grade inflammation, leading to insulin resistance, a key factor in many metabolic diseases. Angiotensin 1–7 (Ang 1–7), a component of the renin-angiotensin system (RAS), exhibits anti-inflammatory effects in obesity and related disorders,...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Adipocyte |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21623945.2024.2449027 |
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| author | Nozomi Nishida Satoru Sugimoto Satoshi Miyagaki Chiharu Cho Madoka Konishi Takeshi Goda Mihoko Yamaguchi Yasuhiro Kawabe Hidechika Morimoto Joji Kusuyama Takuro Okamura Masahide Hamaguchi Jun Mori Hisakazu Nakajima Michiaki Fukui Tomoko Iehara |
| author_facet | Nozomi Nishida Satoru Sugimoto Satoshi Miyagaki Chiharu Cho Madoka Konishi Takeshi Goda Mihoko Yamaguchi Yasuhiro Kawabe Hidechika Morimoto Joji Kusuyama Takuro Okamura Masahide Hamaguchi Jun Mori Hisakazu Nakajima Michiaki Fukui Tomoko Iehara |
| author_sort | Nozomi Nishida |
| collection | DOAJ |
| description | Obesity is a global health concern that promotes chronic low-grade inflammation, leading to insulin resistance, a key factor in many metabolic diseases. Angiotensin 1–7 (Ang 1–7), a component of the renin-angiotensin system (RAS), exhibits anti-inflammatory effects in obesity and related disorders, though its mechanisms remain unclear. In this study, we examined the effect of Ang 1–7 on inflammation of white adipose tissue (WAT) in dietary-induced obese mice. Monocyte chemoattractant protein-1 (MCP-1) produced by white adipocytes and tumour necrosis factor-α (TNF-α) produced by macrophages are pro-inflammatory cytokines and interact to form a pathogenic loop to exacerbate obesity-induced inflammation. We found that Ang 1–7 reduced MCP-1 and TNF-α gene expressions and the number of crown-like structures, which are histological hallmarks of the pro-inflammatory process, in visceral epididymal WAT (eWAT) and reduced circulating MCP-1 and TNF-α levels, accompanied by improvement in insulin resistance, in dietary-induced obese mice. Furthermore, Ang 1–7 reduced MCP-1 and TNF-α secretions in 3T3-L1 white adipocytes and RAW 264.7 macrophages, respectively, which are in vitro experimental models mimicking obesity condition. Our results suggest that Ang 1–7 directly acts on WAT to mitigate obesity-induced inflammation. Thus, this study provides novel insights into the underlying mechanism of anti-obesity effects of Ang 1–7. |
| format | Article |
| id | doaj-art-44de6e71b76a4dfd82f8fe1321d09d10 |
| institution | Kabale University |
| issn | 2162-3945 2162-397X |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Adipocyte |
| spelling | doaj-art-44de6e71b76a4dfd82f8fe1321d09d102025-01-13T12:40:32ZengTaylor & Francis GroupAdipocyte2162-39452162-397X2025-12-0114110.1080/21623945.2024.2449027Anti-inflammatory effect of Angiotensin 1-7 in white adipose tissueNozomi Nishida0Satoru Sugimoto1Satoshi Miyagaki2Chiharu Cho3Madoka Konishi4Takeshi Goda5Mihoko Yamaguchi6Yasuhiro Kawabe7Hidechika Morimoto8Joji Kusuyama9Takuro Okamura10Masahide Hamaguchi11Jun Mori12Hisakazu Nakajima13Michiaki Fukui14Tomoko Iehara15Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanDepartment of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanDepartment of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanDepartment of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanDepartment of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanDepartment of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanDepartment of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanDepartment of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanDepartment of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanDepartment of Biosignals and Inheritance, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, JapanDepartment of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanDepartment of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanDivision of Pediatric Endocrinology, Metabolism and Nephrology, Children’s Medical Center, Osaka City General Hospital, Osaka, JapanDepartment of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanDepartment of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanDepartment of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanObesity is a global health concern that promotes chronic low-grade inflammation, leading to insulin resistance, a key factor in many metabolic diseases. Angiotensin 1–7 (Ang 1–7), a component of the renin-angiotensin system (RAS), exhibits anti-inflammatory effects in obesity and related disorders, though its mechanisms remain unclear. In this study, we examined the effect of Ang 1–7 on inflammation of white adipose tissue (WAT) in dietary-induced obese mice. Monocyte chemoattractant protein-1 (MCP-1) produced by white adipocytes and tumour necrosis factor-α (TNF-α) produced by macrophages are pro-inflammatory cytokines and interact to form a pathogenic loop to exacerbate obesity-induced inflammation. We found that Ang 1–7 reduced MCP-1 and TNF-α gene expressions and the number of crown-like structures, which are histological hallmarks of the pro-inflammatory process, in visceral epididymal WAT (eWAT) and reduced circulating MCP-1 and TNF-α levels, accompanied by improvement in insulin resistance, in dietary-induced obese mice. Furthermore, Ang 1–7 reduced MCP-1 and TNF-α secretions in 3T3-L1 white adipocytes and RAW 264.7 macrophages, respectively, which are in vitro experimental models mimicking obesity condition. Our results suggest that Ang 1–7 directly acts on WAT to mitigate obesity-induced inflammation. Thus, this study provides novel insights into the underlying mechanism of anti-obesity effects of Ang 1–7.https://www.tandfonline.com/doi/10.1080/21623945.2024.2449027Angiotensin 1-7obesityanti-inflammatory effectMCP-1TNF-α |
| spellingShingle | Nozomi Nishida Satoru Sugimoto Satoshi Miyagaki Chiharu Cho Madoka Konishi Takeshi Goda Mihoko Yamaguchi Yasuhiro Kawabe Hidechika Morimoto Joji Kusuyama Takuro Okamura Masahide Hamaguchi Jun Mori Hisakazu Nakajima Michiaki Fukui Tomoko Iehara Anti-inflammatory effect of Angiotensin 1-7 in white adipose tissue Adipocyte Angiotensin 1-7 obesity anti-inflammatory effect MCP-1 TNF-α |
| title | Anti-inflammatory effect of Angiotensin 1-7 in white adipose tissue |
| title_full | Anti-inflammatory effect of Angiotensin 1-7 in white adipose tissue |
| title_fullStr | Anti-inflammatory effect of Angiotensin 1-7 in white adipose tissue |
| title_full_unstemmed | Anti-inflammatory effect of Angiotensin 1-7 in white adipose tissue |
| title_short | Anti-inflammatory effect of Angiotensin 1-7 in white adipose tissue |
| title_sort | anti inflammatory effect of angiotensin 1 7 in white adipose tissue |
| topic | Angiotensin 1-7 obesity anti-inflammatory effect MCP-1 TNF-α |
| url | https://www.tandfonline.com/doi/10.1080/21623945.2024.2449027 |
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