The Liposuction-Induced Effects on Adiponectin and Selected Cytokines Are Not Affected by Exercise Training in Women
It has been suggested that the abrupt liposuction-induced decrease in adipose tissue could affect adipokine secretion pattern. We hypothesized that exercise training could positively impact adipokine metabolism following liposuction. The aim of this study was to investigate the effects of liposuctio...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2014/315382 |
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| author | Marina Yazigi Solis Guilherme Giannini Artioli Eduardo Montag Vitor de Salles Painelli Fábio Lopes Saito Fernanda Rodrigues Lima Hamilton Roschel Bruno Gualano Antonio Herbert Lancha Junior Fabiana Braga Benatti |
| author_facet | Marina Yazigi Solis Guilherme Giannini Artioli Eduardo Montag Vitor de Salles Painelli Fábio Lopes Saito Fernanda Rodrigues Lima Hamilton Roschel Bruno Gualano Antonio Herbert Lancha Junior Fabiana Braga Benatti |
| author_sort | Marina Yazigi Solis |
| collection | DOAJ |
| description | It has been suggested that the abrupt liposuction-induced decrease in adipose tissue could affect adipokine secretion pattern. We hypothesized that exercise training could positively impact adipokine metabolism following liposuction. The aim of this study was to investigate the effects of liposuction on inflammation-related adipokines in women who were either exercise-trained or remained sedentary after surgery. Thirty-six healthy normal-weight women underwent an abdominal liposuction and two months after surgery were randomly allocated into two groups: trained (TR, n=18, four-month exercise program) and nontrained (NT, n=18). Inflammation-related adipokine serum levels (TNF-α, IL-6, IL-10, and adiponectin) and abdominal and thigh subcutaneous adipose tissue (scAT) mRNA levels were assessed before (PRE) and six months after surgery (POST6). TNF-α, IL-6, and IL-10 serum levels were unchanged in both groups. In contrast, TNF-α, IL-6, and IL-10 mRNA levels in scAT were increased, whereas adiponectin scAT mRNA and serum levels were decreased at POST6 (P<0.05, main effect for time). No changes were observed in mRNA levels of MCP-1, CD14, and CD68 in any of the groups. In conclusion, liposuction downregulates adiponectin scAT gene expression and serum levels and upregulates scAT gene expression of inflammation-related genes six months after surgery in normal-weight women, irrespective of exercise training. |
| format | Article |
| id | doaj-art-44a6bfea3e9d41dcb3e067ab6843e42b |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-44a6bfea3e9d41dcb3e067ab6843e42b2025-02-03T05:47:17ZengWileyInternational Journal of Endocrinology1687-83371687-83452014-01-01201410.1155/2014/315382315382The Liposuction-Induced Effects on Adiponectin and Selected Cytokines Are Not Affected by Exercise Training in WomenMarina Yazigi Solis0Guilherme Giannini Artioli1Eduardo Montag2Vitor de Salles Painelli3Fábio Lopes Saito4Fernanda Rodrigues Lima5Hamilton Roschel6Bruno Gualano7Antonio Herbert Lancha Junior8Fabiana Braga Benatti9School of Medicine, University of Sao Paulo, Av. Dr. Eneas de Carvalho Aguiar, 255, 05403-000 Sao Paulo, SP, BrazilSchool of Physical Education and Sport, University of Sao Paulo, Rua Professor Mello Moraes, 65, 05025-010 Sao Paulo, SP, BrazilSchool of Medicine, University of Sao Paulo, Av. Dr. Eneas de Carvalho Aguiar, 255, 05403-000 Sao Paulo, SP, BrazilSchool of Physical Education and Sport, University of Sao Paulo, Rua Professor Mello Moraes, 65, 05025-010 Sao Paulo, SP, BrazilSchool of Medicine, University of Sao Paulo, Av. Dr. Eneas de Carvalho Aguiar, 255, 05403-000 Sao Paulo, SP, BrazilSchool of Medicine, University of Sao Paulo, Av. Dr. Eneas de Carvalho Aguiar, 255, 05403-000 Sao Paulo, SP, BrazilSchool of Medicine, University of Sao Paulo, Av. Dr. Eneas de Carvalho Aguiar, 255, 05403-000 Sao Paulo, SP, BrazilSchool of Medicine, University of Sao Paulo, Av. Dr. Eneas de Carvalho Aguiar, 255, 05403-000 Sao Paulo, SP, BrazilSchool of Physical Education and Sport, University of Sao Paulo, Rua Professor Mello Moraes, 65, 05025-010 Sao Paulo, SP, BrazilSchool of Medicine, University of Sao Paulo, Av. Dr. Eneas de Carvalho Aguiar, 255, 05403-000 Sao Paulo, SP, BrazilIt has been suggested that the abrupt liposuction-induced decrease in adipose tissue could affect adipokine secretion pattern. We hypothesized that exercise training could positively impact adipokine metabolism following liposuction. The aim of this study was to investigate the effects of liposuction on inflammation-related adipokines in women who were either exercise-trained or remained sedentary after surgery. Thirty-six healthy normal-weight women underwent an abdominal liposuction and two months after surgery were randomly allocated into two groups: trained (TR, n=18, four-month exercise program) and nontrained (NT, n=18). Inflammation-related adipokine serum levels (TNF-α, IL-6, IL-10, and adiponectin) and abdominal and thigh subcutaneous adipose tissue (scAT) mRNA levels were assessed before (PRE) and six months after surgery (POST6). TNF-α, IL-6, and IL-10 serum levels were unchanged in both groups. In contrast, TNF-α, IL-6, and IL-10 mRNA levels in scAT were increased, whereas adiponectin scAT mRNA and serum levels were decreased at POST6 (P<0.05, main effect for time). No changes were observed in mRNA levels of MCP-1, CD14, and CD68 in any of the groups. In conclusion, liposuction downregulates adiponectin scAT gene expression and serum levels and upregulates scAT gene expression of inflammation-related genes six months after surgery in normal-weight women, irrespective of exercise training.http://dx.doi.org/10.1155/2014/315382 |
| spellingShingle | Marina Yazigi Solis Guilherme Giannini Artioli Eduardo Montag Vitor de Salles Painelli Fábio Lopes Saito Fernanda Rodrigues Lima Hamilton Roschel Bruno Gualano Antonio Herbert Lancha Junior Fabiana Braga Benatti The Liposuction-Induced Effects on Adiponectin and Selected Cytokines Are Not Affected by Exercise Training in Women International Journal of Endocrinology |
| title | The Liposuction-Induced Effects on Adiponectin and Selected Cytokines Are Not Affected by Exercise Training in Women |
| title_full | The Liposuction-Induced Effects on Adiponectin and Selected Cytokines Are Not Affected by Exercise Training in Women |
| title_fullStr | The Liposuction-Induced Effects on Adiponectin and Selected Cytokines Are Not Affected by Exercise Training in Women |
| title_full_unstemmed | The Liposuction-Induced Effects on Adiponectin and Selected Cytokines Are Not Affected by Exercise Training in Women |
| title_short | The Liposuction-Induced Effects on Adiponectin and Selected Cytokines Are Not Affected by Exercise Training in Women |
| title_sort | liposuction induced effects on adiponectin and selected cytokines are not affected by exercise training in women |
| url | http://dx.doi.org/10.1155/2014/315382 |
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